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Collagen Extraction from Bone of Lutjanus sp. and Toxicity Assay

Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) · Vol. ume No. 1 (2019) · pp. 67–72

DOI
10.70561/ica.v12i1.5925
ISSN
2655-6049, 2085-014X
Published
2019-05-30
Publisher
Hasanuddin University
Language
en

Abstract

Indonesia is a maritime country with the potential fisheries resources. However, utilization only revolves around the meat, while other parts have not been used optimally, especially fish bones which have the potential to produce collagen, so it needs to be developed. The aims of this study ware extracted collagen from bone of Lutjanus sp. and determine its the Anticancer activity. The collagen was extracted by using hydroextraction method and identification by FTIR. The initial screening anticancer activity was done by using Brine Shrimp Lethality Test (BSLT) method for toxicity assay. The results showed that the yield of collagen was 4.535% with protein concentration was 8,815 mg/mL. Identified collagen from spectrum of amide A, B, I, II, and III at 3421.72; 2926.01; 1651.07; 1541.12; 1240.23 cm-1. The toxicity test was shown in LC50 values of 8,760 μg/mL. The collagen from Lutjanus sp. bone can be used as natural anticancer agent.

Keywords

Collaboration network of the authors

40 authors · 99 co-authorship links · showing the 40 most connected

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  • Universitas Muhammadiyah Buton
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Ahyar AhmadAffiliation unknown6
Abdur Rahman ArifAffiliation unknown4
Muhammad ZakirAffiliation unknown3
Leliani LelianiAffiliation unknown3
Muawanah MuawanahAffiliation unknown2
Ischaidar IschaidarAffiliation unknown2
Hanapi UsmanAffiliation unknown2
ABDUL KARIMAffiliation unknown2
Alfian Nasir MaidinAffiliation unknown2
Lupita Denta PutriAffiliation unknown2
Rugaiyah A ArfahAffiliation unknown1
St Fauziah St FauziahAffiliation unknown1
Prastawa BudiAffiliation unknown1
Indah RayaAffiliation unknown1
Erna MayasariAffiliation unknown1
Nursiah La NafieAffiliation unknown1
Sabaniah Indjar GamaAffiliation unknown1
Paulina TabaAffiliation unknown1
Fatahu FatahuAffiliation unknown1
Sarwina HafidAffiliation unknown1
Firdaus FirdausAffiliation unknown1
Nunuk Hariani SoekamtoAffiliation unknown1
Selfi WullurAffiliation unknown1
Rauf PatongAffiliation unknown1
Muhammad Noor DjalaluddinAffiliation unknown1
Pirman APAffiliation unknown1
Adriani AdrianiAffiliation unknown1
Emmi AstutiAffiliation unknown1
Sulfiani SulfianiAffiliation unknown1
Nursyamsi NursyamsiAffiliation unknown1
Fitriani BUniversitas Muhammadiyah Buton1
Nur AsmiAffiliation unknown1
Harningsih KarimAffiliation unknown1
Ali MuhakimAffiliation unknown1
Siti KhairunnurAffiliation unknown1
Nur HaedarAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ica/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Collagen Extraction from Bone of  Lutjanus sp. and Toxicity Assay</dc:title>
	<dc:creator xml:lang="en">Ramli, Leliani</dc:creator>
	<dc:creator xml:lang="en">Natsir, Hasnah</dc:creator>
	<dc:creator xml:lang="en">Dali, Seniwati</dc:creator>
	<dc:creator xml:lang="en">Danial, Sartika</dc:creator>
	<dc:subject xml:lang="en">Collagen</dc:subject>
	<dc:subject xml:lang="en">Lutjanus sp.</dc:subject>
	<dc:subject xml:lang="en">Bone</dc:subject>
	<dc:subject xml:lang="en">Anticancer</dc:subject>
	<dc:subject xml:lang="en">Hidroextraction</dc:subject>
	<dc:subject xml:lang="en">BSLT</dc:subject>
	<dc:description xml:lang="en">Indonesia is a maritime country with the potential fisheries resources. However, utilization only revolves around the meat, while other parts have not been used optimally, especially fish bones which have the potential to produce collagen, so it needs to be developed. The aims of this study ware extracted collagen from bone of Lutjanus sp. and determine its the Anticancer activity. The collagen was extracted by using hydroextraction method and identification by FTIR. The initial screening anticancer activity was done by using Brine Shrimp Lethality Test (BSLT) method for toxicity assay. The results showed that the yield of collagen was 4.535% with protein concentration was 8,815 mg/mL. Identified collagen from spectrum of amide A, B, I, II, and III at 3421.72; 2926.01; 1651.07; 1541.12; 1240.23 cm-1. The toxicity test was shown in LC50 values of  8,760 μg/mL. The collagen from Lutjanus sp. bone can be used as natural anticancer agent.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2019-05-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ica/article/view/5925</dc:identifier>
	<dc:identifier>10.70561/ica.v12i1.5925</dc:identifier>
	<dc:source xml:lang="en">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta); Volume 12, No.1: June 2019; 67-72</dc:source>
	<dc:source>2655-6049</dc:source>
	<dc:source>2085-014X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ica/article/view/5925/3604</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta)</dc:rights>
</oai_dc:dc>