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A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells

Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) · Vol. ume No. 2 (2020) · pp. 38–42

DOI
10.70561/ica.v13i2.10962
ISSN
2655-6049, 2085-014X
Published
2020-12-14
Publisher
Hasanuddin University
Language
en
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.

Keywords

Collaboration network of the authors

40 authors · 97 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Adri AdriAffiliation unknown8
Suharyon SuharyonAffiliation unknown5
Erwin AnshariAffiliation unknown4
Alfian NoorAffiliation unknown4
Nunuk Hariani SoekamtoAffiliation unknown3
Wd Rizky AwaliahAffiliation unknown2
Nur Imdah MinsyahAffiliation unknown2
Syafri EdiAffiliation unknown2
Ajuk SaparAffiliation unknown2
Tri Aryono HadiAffiliation unknown2
Almin AlminAffiliation unknown1
Muhammad AchidaAffiliation unknown1
Laode Muhammad BuyungAffiliation unknown1
Ali ArsadAffiliation unknown1
Hasnawati HasnawatiUniversitas Halu Oleo1
Marwan Zam MiliAffiliation unknown1
Wahab WahabUniversitas Halu Oleo1
Alfian Hendra SaputraAffiliation unknown1
Deniyatno DeniyatnoAffiliation unknown1
La Ode ResteleAffiliation unknown1
Hasria HasriaAffiliation unknown1
Muliddin MuliddinAffiliation unknown1
Ali OktoUniversitas Halu Oleo1
Suparwi SuparwiAffiliation unknown1
Ade SaputraAffiliation unknown1
Ritna WahyuniAffiliation unknown1
Dhanu Bagas PratomoAffiliation unknown1
Raditya Janaloka NatishareviAffiliation unknown1
Jose RizalAffiliation unknown1
Pepi NoviantiAffiliation unknown1
Wina Ayu LestariAffiliation unknown1
Defira Suci GusfarinaAffiliation unknown1
Erwan WahyudiAffiliation unknown1
Jon HendriAffiliation unknown1
Busyra B. SaidiAffiliation unknown1
Yardha YardhaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ica/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells</dc:title>
	<dc:creator xml:lang="en">Firdaus, Firdaus</dc:creator>
	<dc:creator xml:lang="en">Soekamto, Nunuk Hariani</dc:creator>
	<dc:creator xml:lang="en">Firdausiah, Syadza</dc:creator>
	<dc:creator xml:lang="en">Tahar, Musrifah</dc:creator>
	<dc:subject xml:lang="en">anticancer</dc:subject>
	<dc:subject xml:lang="en">caffeamide</dc:subject>
	<dc:subject xml:lang="en">caffeic acid</dc:subject>
	<dc:subject xml:lang="en">piperidine</dc:subject>
	<dc:subject xml:lang="en">P388</dc:subject>
	<dc:description xml:lang="en">Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2020-12-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ica/article/view/10962</dc:identifier>
	<dc:identifier>10.70561/ica.v13i2.10962</dc:identifier>
	<dc:source xml:lang="en">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta); Volume 13, No 2: December 2020; 38-42</dc:source>
	<dc:source>2655-6049</dc:source>
	<dc:source>2085-014X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ica/article/view/10962/6159</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta)</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>