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ROLES OF VITAMIN C AND VITAMIN E ON DOXORUBICIN-INDUCED RENAL AND LIVER TOXICITY IN RATS

Nusantara Medical Science Journal · Vol. ume No. 2 (2017) · pp. 16–23

DOI
10.20956/nmsj.v1i2.2213
ISSN
2597-7288, 2460-9757
Published
2017-08-04
Publisher
Faculty of Medicine, Hasanuddin University.
Language
en

Abstract

ABSTRACT Introduction: Doxorubicin (DOX) is a chemotherapy agent that has potent effects against various cancer types. However, DOX may elicit renal and liver toxicity. Objectives: To examine the role of vitamin C and vitamin E in reducing DOX renal and liver toxicity. Methods: Male rats (220-330 g) were assigned to one of the treatment groups. Group I was healthy controls. Group II was given DOX (20 mg/kg b.wt). Group III was given vitamin C (250 mg/kg b.wt) for 7 days prior to DOX injection. Group IV was given vitamin E (250 mg/kg b.wt) for 7 days prior to DOX injection. Group V was given oil vehicle for 7 days prior to DOX injection. Results: Vitamin C was effective to reduce both renal and liver dysfunction. However, vitamin E protective effects were only convincing in lowering DOX-induced renal toxicity but not liver toxicity. Both vitamins prevented elevated DOX-induced oxidative stress. Conclusion: Both vitamin C and vitamin E can help to reduce DOX toxicity in rat kidney, but only vitamin C that has clear benefits on improving liver toxicity after DOX injection. Keywords: Doxorubicin, renal toxicity, liver toxicity, vitamin E, vitamin C

Collaboration network of the authors

40 authors · 137 co-authorship links · showing the 40 most connected

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Co-authorOrganisationJoint articles
Subehan LalloAffiliation unknown5
Sartini SartiniAffiliation unknown4
Hasyim KasimAffiliation unknown4
M Natsir DjideAffiliation unknown4
Gemini AlamAffiliation unknown3
Risfah YuliantyAffiliation unknown3
Latifah RahmanAffiliation unknown3
Aliyah AliyahAffiliation unknown3
Herlina RanteAffiliation unknown3
Rosany TayebAffiliation unknown3
Yusnita RifaiAffiliation unknown2
SartiniAffiliation unknown2
Muhammad husni CangaraAffiliation unknown2
Dwi Kesuma SariAffiliation unknown2
M Aryadi ArsyadAffiliation unknown2
Sartini NatsirAffiliation unknown2
Mirnawati SalampeAffiliation unknown2
Marianti A. ManggauAffiliation unknown2
Suryanita SuryanitaAffiliation unknown2
Sumarheni SumarheniAffiliation unknown2
Ari SulistyantoAffiliation unknown1
Hermiyetti HermiyettiAffiliation unknown1
Jumasni AdnanAffiliation unknown1
Mufidah MufidahAffiliation unknown1
Peter KaboAffiliation unknown1
Zhulhajsyirah ZhulhajsyirahAffiliation unknown1
Jumriani TammasAffiliation unknown1
Sri YolandariAffiliation unknown1
Asniar PascayantriAffiliation unknown1
Tuti Handayani ZainalAffiliation unknown1
Andi Nurpati PanaungiAffiliation unknown1
Restuyani ParanoanAffiliation unknown1
Zulfaidah RahmaAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">ROLES OF VITAMIN C AND VITAMIN E ON DOXORUBICIN-INDUCED RENAL AND LIVER TOXICITY IN RATS</dc:title>
	<dc:creator xml:lang="en">Djabir, Yulia Yusrini</dc:creator>
	<dc:creator xml:lang="en">Usmar, Usmar</dc:creator>
	<dc:creator xml:lang="en">Wahyudin, Elly</dc:creator>
	<dc:creator xml:lang="en">Mamada, Sukamto S</dc:creator>
	<dc:creator xml:lang="en">Hamka, Ika Reskia N</dc:creator>
	<dc:creator xml:lang="en">S. Putri, Dila Pramitha</dc:creator>
	<dc:creator xml:lang="en">Amalia, Irma</dc:creator>
	<dc:description xml:lang="en">ABSTRACT Introduction: Doxorubicin (DOX) is a chemotherapy agent that has potent effects against various cancer types. However, DOX may elicit renal and liver toxicity. Objectives: To examine the role of vitamin C and vitamin E in reducing DOX renal and liver toxicity. Methods: Male rats (220-330 g) were assigned to one of the treatment groups. Group I was healthy controls. Group II was given DOX (20 mg/kg b.wt). Group III was given vitamin C (250 mg/kg b.wt) for 7 days prior to DOX injection. Group IV was given vitamin E (250 mg/kg b.wt) for 7 days prior to DOX injection. Group V was given oil vehicle for 7 days prior to DOX injection. Results: Vitamin C was effective to reduce both renal and liver dysfunction. However, vitamin E protective effects were only convincing in lowering DOX-induced renal toxicity but not liver toxicity. Both vitamins prevented elevated DOX-induced oxidative stress. Conclusion: Both vitamin C and vitamin E can help to reduce DOX toxicity in rat kidney, but only vitamin C that has clear benefits on improving liver toxicity after DOX injection. Keywords: Doxorubicin, renal toxicity, liver toxicity, vitamin E, vitamin C</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2017-08-04</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/2213</dc:identifier>
	<dc:identifier>10.20956/nmsj.v1i2.2213</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 1 No. 2  April - Juni 2016; 16-23</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/2213/1232</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Nusantara Medical Science Journal</dc:rights>
</oai_dc:dc>