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THE IMPACT OF THE FREQUENCY OF 7,12- DIMETHYLBENZ [Á] ANTHRACENE (DMBA) ADMINISTRATION ON THE FORMATION OF DYSPLASIA AND SQUAMOUS CELL CARCINOMA ON THE SKIN OF ALBINO MICE

Nusantara Medical Science Journal · Vol. ume No. 4 (2017) · hlm. 121–126

DOI
10.20956/nmsj.v1i4.2248
ISSN
2597-7288, 2460-9757
Terbit
2017-08-09
Penerbit
Faculty of Medicine, Hasanuddin University.
Bahasa
en

Abstrak

ABSTRACT Introduction: Dosage and frequency of 7,12-dimethylbenz[á] anthracene (DMBA) com- pound exposure suspected to affect the rapid growth of squamous cell carcinoma (SCC) in albino mice. Objective: find out the impact of DMBA exposure to dysplasia and SCC formation on albino mice. Methods: Twenty-five albino mice were divided into five groups, namely: Group 1 is the control (acetone), group 2 is 5 albino mice given four times DMBA100 µg exposure for eight weeks, group 3 is 5 albino mice were given eight times DMBA100 µg exposure for eight weeks, group 4 is 5 albino mice were given twelve times DMBA100 µg exposure for eight weeks, and group 5 is 5 albino mice were given sixteen times DMBA 100 µg exposure for eight weeks. Histopathological examination were conducted to assess histopathological feature including inflammation, dysplasia, and SCC. Results: There is a significant effect of the frequency of DMBA exposure to the clinical figure and against histopathological feature of the skin albino mice.Conclusions: Dosage and fre- quency of DMBA exposure affect the occurence of dysplasia and SCC, which are in- creasingly being DMBA exposure will accelerate the growth of SCC. The frequency of the most widely pose a SCC in DMBA 100 µg sixteen times exposure group, twice a week for eight weeks. Keywords: DMBA, dysplasia, squamous cell carcinoma

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  • Hasanuddin University
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Rekan penulisOrganisasiArtikel bersama
Kusrini KadarHasanuddin University1
Irma AndrianysAfiliasi tidak diketahui1
Budu BuduHasanuddin University1
Andi Muhammad IchsanHasanuddin University1
Habibah Setyawati MuhiddinHasanuddin University1
Arifin SewengHasanuddin University1
Nirmayanti JalilHasanuddin University1
Ana-Maria AdamHasanuddin University1
Risna HalimHasanuddin University1
Anni AdrianiHasanuddin University1
Siti Aizah LawangAfiliasi tidak diketahui1
Astri Amelia GosalAfiliasi tidak diketahui1
Hadia AngrianiAfiliasi tidak diketahui1
Ratna Dewi ArtatiAfiliasi tidak diketahui1
JusliAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">THE IMPACT OF THE FREQUENCY OF 7,12- DIMETHYLBENZ [Á] ANTHRACENE (DMBA) ADMINISTRATION ON THE FORMATION OF DYSPLASIA AND SQUAMOUS CELL CARCINOMA ON THE SKIN OF ALBINO MICE</dc:title>
	<dc:creator xml:lang="en">Muchsin, Diana</dc:creator>
	<dc:creator xml:lang="en">Djawad, Khairuddin</dc:creator>
	<dc:creator xml:lang="en">Mappiasse, Alwi A</dc:creator>
	<dc:creator xml:lang="en">Ganda, Idham Jaya</dc:creator>
	<dc:creator xml:lang="en">Massi, Nasrum</dc:creator>
	<dc:creator xml:lang="en">Alam, Gemini</dc:creator>
	<dc:description xml:lang="en">ABSTRACT Introduction: Dosage and frequency of 7,12-dimethylbenz[á] anthracene (DMBA)  com- pound exposure suspected to affect the rapid growth of squamous cell carcinoma (SCC) in albino mice. Objective: find out the impact of DMBA exposure to dysplasia and SCC formation on albino mice. Methods: Twenty-five albino mice were divided into five groups, namely: Group 1 is the control (acetone), group 2 is 5 albino mice given four times DMBA100 µg exposure for eight weeks, group 3 is 5 albino mice were given eight times DMBA100 µg exposure for eight weeks, group 4 is 5 albino mice were given twelve times DMBA100 µg exposure for eight weeks, and group 5 is 5 albino mice were given sixteen times DMBA 100 µg exposure for eight weeks. Histopathological examination were conducted to assess histopathological feature including inflammation, dysplasia, and SCC. Results: There is a significant effect of the frequency of DMBA exposure to the clinical figure and against histopathological feature of the skin albino mice.Conclusions:  Dosage and fre- quency of DMBA exposure affect the occurence of dysplasia and SCC, which are in- creasingly being DMBA exposure will accelerate the growth of SCC. The frequency of the most widely pose a SCC in DMBA 100 µg sixteen times exposure group, twice a week for eight weeks. Keywords: DMBA, dysplasia, squamous cell carcinoma</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2017-08-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/2248</dc:identifier>
	<dc:identifier>10.20956/nmsj.v1i4.2248</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 1 No. 4 Oktober - Desember 2016; 121-126</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v1i4</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/2248/1241</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Nusantara Medical Science Journal</dc:rights>
</oai_dc:dc>