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The protective effect of Paliasa (Kleinhovia hospita L.) leaf extract against elevated total bilirubin serum induced by toxic dose of antituberculosis in rats

Nusantara Medical Science Journal · Vol. ume No. 2 (2019) · pp. 43–47

DOI
10.20956/nmsj.v4i2.6474
ISSN
2597-7288, 2460-9757
Published
2019-10-18
Publisher
Faculty of Medicine, Hasanuddin University.
Language
en

Abstract

Liver dysfunction is implicated with the use of Antituberculosis (AT) leading to low compliance of TB patients to AT regimen. One of biomarker that is important to measure liver dysfunction is total bilirubin serum. Paliasa leaves have been emiprically used to improve liver function in South Sulawesi. This study aimed to determine the effect of ethanolic extract of Paliasa leaves on total bilirubin serum in rats. Twenty rats were devided into five groups: Group I served as the healthy control was only given NaCMC suspension, group II was treated with 178 mg/200gBB of AT suspension, while group III, group IV and group V were given Paliasa extract 125 mg/kgBB, 250mg/kgBB and 500 mg/kgBB, respectively, 4 hours prior to AT suspension administration. Treatments were performed once a day for 28 days. Blood sampling was carried out 24 hours following the last treatment. The total bilirubin levels were measured using Humalyzer 3500. The results showed that the administrations of AT suspension for 28 days significantly increased rat total bilirubin levels. Paliasa leaf extract in all given dose was able to reduce the total bilirubin levels of rats compared to the group given only AT suspension. However, statistical significance was only reached by the groups that were treated with Paliasa extract 250 and 500 mg/kgBB. Therefore it is concluded that ethanol extract at a dose of 250 and 500 mg/kgBB has protective effect against AT-induced elevation of total bilirubin serum in rats.

Keywords

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40 authors · 133 co-authorship links · showing the 40 most connected

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Subehan LalloAffiliation unknown4
Elly WahyudinAffiliation unknown4
Sartini SartiniAffiliation unknown3
M Natsir DjideAffiliation unknown3
Gemini AlamAffiliation unknown2
Latifah RahmanAffiliation unknown2
Aliyah AliyahAffiliation unknown2
Muhammad husni CangaraAffiliation unknown2
Dwi Kesuma SariAffiliation unknown2
M Aryadi ArsyadAffiliation unknown2
Sartini NatsirAffiliation unknown2
Herlina RanteAffiliation unknown2
Risfah YuliantyAffiliation unknown2
Usmar UsmarAffiliation unknown2
Jumasni AdnanAffiliation unknown1
Mufidah MufidahAffiliation unknown1
Mirnawati SalampeAffiliation unknown1
Peter KaboAffiliation unknown1
Andi Nurpati PanaungiAffiliation unknown1
Marianti A. ManggauAffiliation unknown1
Hasyim KasimAffiliation unknown1
Restuyani ParanoanAffiliation unknown1
Suryanita SuryanitaAffiliation unknown1
Munawarah MunawarahAffiliation unknown1
Arif SantosoAffiliation unknown1
Ade Christie LewerissaAffiliation unknown1
Akhmad Rafi'iAffiliation unknown1
Ismail IsmailAffiliation unknown1
Fityatun UsmanAffiliation unknown1
Devi Yulianti YusraAffiliation unknown1
Ainun Amalia SultangAffiliation unknown1
Putri Nur HafifahAffiliation unknown1
Yusril Dwimeddy TunggelengAffiliation unknown1
Muh.Akbar BaharAffiliation unknown1
Yani PratiwiAffiliation unknown1
A. AnggrianiAffiliation unknown1
NurhaeniAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The protective effect of Paliasa (Kleinhovia hospita L.) leaf extract against elevated total bilirubin serum induced by toxic dose of antituberculosis in rats</dc:title>
	<dc:creator xml:lang="en">Djabir, Yulia Yusrini</dc:creator>
	<dc:creator xml:lang="en">Meylin, Imelda Dhea</dc:creator>
	<dc:creator xml:lang="en">Tayeb, Rosany</dc:creator>
	<dc:subject xml:lang="en">Antituberculosis</dc:subject>
	<dc:subject xml:lang="en">Paliasa leaf extract</dc:subject>
	<dc:subject xml:lang="en">total bilirubin serum</dc:subject>
	<dc:description xml:lang="en">Liver dysfunction is implicated with the use of Antituberculosis (AT) leading to low compliance of TB patients to AT regimen. One of biomarker that is important to measure liver dysfunction is total bilirubin serum. Paliasa leaves have been emiprically used to improve liver function in South Sulawesi. This study aimed to determine the effect of ethanolic extract of Paliasa leaves on total bilirubin serum in rats. Twenty rats were devided into five groups: Group I served as the healthy control was only given NaCMC suspension, group II was treated with 178 mg/200gBB of AT suspension, while group III, group IV and group V  were given Paliasa extract 125 mg/kgBB, 250mg/kgBB and 500 mg/kgBB, respectively, 4 hours prior to AT suspension administration. Treatments were performed once a day for 28 days. Blood sampling was carried out 24 hours following the last treatment. The total bilirubin levels were measured using Humalyzer 3500. The results showed that the administrations of AT suspension for 28 days significantly increased rat total bilirubin levels. Paliasa leaf extract in all given dose was able to reduce the total bilirubin levels of rats compared to the group given only AT suspension. However, statistical significance was only reached by the groups that were treated with Paliasa extract 250 and 500 mg/kgBB. Therefore it is concluded that ethanol extract at a dose of 250 and 500 mg/kgBB has protective effect against AT-induced elevation of total bilirubin serum in rats.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2019-10-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/6474</dc:identifier>
	<dc:identifier>10.20956/nmsj.v4i2.6474</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 4 No. 2 Juli - Desember 2019; 43-47</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v4i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/6474/4234</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 Nusantara Medical Science Journal</dc:rights>
</oai_dc:dc>