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Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi

Nusantara Medical Science Journal · Vol. ume No. 2 (2021) · hlm. 61–70

DOI
10.20956/nmsj.v5i2.8181
ISSN
2597-7288, 2460-9757
Terbit
2021-04-05
Penerbit
Faculty of Medicine, Hasanuddin University.
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.Keywords: Hypertension, cucumber extract, In Silico, In Vitro

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  • Hasanuddin University
  • Universitas Jambi
  • Universiti Teknikal Malaysia Melaka
  • Indonesia University of Education
  • Lviv Polytechnic National University
  • Universiti Malaysia Pahang Al-Sultan Abdullah
  • Universitas Pendidikan Ganesha
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Rekan penulisOrganisasiArtikel bersama
Sosiawan NusiferaUniversitas Jambi3
Budiyati IchwanUniversitas Jambi2
Jamil Abedalrahim Jamil AlsayaydehUniversiti Teknikal Malaysia Melaka1
Nataliia LotoshynskaLviv Polytechnic National University1
Solomiya PopovaLviv Polytechnic National University1
Iis Roin WidiatiAfiliasi tidak diketahui1
Reni RochmawatiAfiliasi tidak diketahui1
Didi S.S. MabuiAfiliasi tidak diketahui1
Sitti FatimahAfiliasi tidak diketahui1
Nor Azizah Mohd YusoffUniversiti Teknikal Malaysia Melaka1
Mohd Fariduddin MukhtarUniversiti Teknikal Malaysia Melaka1
Sayed Kushairi Sayed NordinUniversiti Teknikal Malaysia Melaka1
Najiyah Safwa Khashi’ieUniversiti Teknikal Malaysia Melaka1
Nurul Amira ZainalUniversiti Teknikal Malaysia Melaka1
Sahimel Azwal SulaimanUniversiti Malaysia Pahang Al-Sultan Abdullah1
Asniwita AsniwitaUniversitas Jambi1
Wilyus WilyusUniversitas Jambi1
Fuad NurdiansyahUniversitas Jambi1
Sella OktaviaUniversitas Jambi1
Hastuti HastutiHasanuddin University1
Hasnah HasnahHasanuddin University1
Adi Ahmad GondoAfiliasi tidak diketahui1
Irianto IriantoUniversitas Jambi1
Naurah NadhifahHasanuddin University1
Andi Besse AhsaniyahHasanuddin University1
Armita Iswardani IrawanHasanuddin University1
Nurhikmawaty NurhikmawatyHasanuddin University1
Tatang HermanIndonesia University of Education1
Didi SuryadiIndonesia University of Education1
I Made SuarsanaUniversitas Pendidikan Ganesha1
Al JupriIndonesia University of Education1
Elah NurlaelahIndonesia University of Education1
Asep Bayu Dani NandiyantoIndonesia University of Education1
Zulkaidah Nur AhzanUniversity of Timor1
An'gun Dhuha Dive PutraUniversitas Jambi1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi</dc:title>
	<dc:creator xml:lang="en">Irianto, Irianto</dc:creator>
	<dc:creator xml:lang="en">Armyn, Andi Alief Utama </dc:creator>
	<dc:creator xml:lang="en">Hijriansyah, La Ode Abdul Haris </dc:creator>
	<dc:creator xml:lang="en">Hermilasari, Hermilasari</dc:creator>
	<dc:creator xml:lang="en">Subair, Hardyanty </dc:creator>
	<dc:subject xml:lang="en">Hypertension</dc:subject>
	<dc:subject xml:lang="en">cucumber extract</dc:subject>
	<dc:subject xml:lang="en">In Silico</dc:subject>
	<dc:subject xml:lang="en">In Vitro</dc:subject>
	<dc:description xml:lang="en">Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.Keywords: Hypertension, cucumber extract, In Silico, In Vitro</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2021-04-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/8181</dc:identifier>
	<dc:identifier>10.20956/nmsj.v5i2.8181</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 5 No. 2 Juli - Desember 2020; 61-70</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v5i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/8181/6697</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Nusantara Medical Science Journal</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>