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Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD)

Nusantara Medical Science Journal · Vol. ume (2022) · hlm. 93–102

DOI
10.20956/nmsj.v6i2.18850
ISSN
2597-7288, 2460-9757
Terbit
2022-01-16
Penerbit
Faculty of Medicine, Hasanuddin University.
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods: This study was designed for a cross-sectional study. 65 acute exacerbation COPD patients were selected. The serum level of Interleukin-1β was recorded. Results: Most of the subjects are men (95,4%), moderate smokers (41,5%), normal BMI (61,5%), more than 60 years old (73,8%), have more than 2 exacerbations in a year (67%), severe airway obstruction (41,5%) and mostly in group D (80%). The mean level of Interleukin-1β was 1.63 pg/ml range from 0,009-17,62 pg/ml. Kruskal Wallis analysis test noticed significant differentiation mean serum level of Interleukin-1β in several groups of GOLD. p 0.05. Conclusions: there was no correlation between the severity of airway obstruction with serum level of IL-1β in acute exacerbation of COPD. there was a vicious trend of increasing IL-1β serum level according to the severity of airway obstruction mainly seen in GOLD 2, GOLD 3, and GOLD 4.

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  • Hasanuddin University
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Rekan penulisOrganisasiArtikel bersama
Sri AsriyaniHasanuddin University1
Bachtiar MurtalaHasanuddin University1
Nur Amelia BachtiarHasanuddin University1
Andi Alfian ZainuddinHasanuddin University1
Nikmatia LatiefHasanuddin University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Correlation between Interleukin-1β serum level with severity of airway obstruction in Exacerbation Chronic obstructive pulmonary disease (COPD)</dc:title>
	<dc:creator xml:lang="en">Budi Mulya, Nurfajar</dc:creator>
	<dc:creator xml:lang="en">Ilyas, Muhamad</dc:creator>
	<dc:creator xml:lang="en">Arief, Erwin </dc:creator>
	<dc:creator xml:lang="en">Djaharuddin, Irawaty</dc:creator>
	<dc:creator xml:lang="en">Nurisyah, Siti</dc:creator>
	<dc:creator xml:lang="en">Putrawan, Harry Akza </dc:creator>
	<dc:description xml:lang="en">Introduction: To observe the relation between Interleukin-1β with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Methods:  This study was designed for a cross-sectional study. 65 acute exacerbation COPD patients were selected. The serum level of Interleukin-1β was recorded. Results:  Most of the subjects are men (95,4%), moderate smokers (41,5%), normal BMI (61,5%), more than 60 years old (73,8%), have more than 2 exacerbations in a year (67%), severe airway obstruction (41,5%) and mostly in group D (80%). The mean level of Interleukin-1β was 1.63 pg/ml range from 0,009-17,62 pg/ml. Kruskal Wallis analysis test noticed significant differentiation mean serum level of Interleukin-1β in several groups of GOLD. p&amp;lt;0,05. There was no correlation between serum level of IL-1β with the severity of airway obstruction (GOLD) p&amp;gt;0.05. Conclusions: there was no correlation between the severity of airway obstruction with serum level of IL-1β in acute exacerbation of COPD. there was a vicious trend of increasing IL-1β serum level according to the severity of airway obstruction mainly seen in GOLD 2, GOLD 3, and GOLD 4.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2022-01-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/18850</dc:identifier>
	<dc:identifier>10.20956/nmsj.v6i2.18850</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 6 Issue 2, July - December 2021; 93-102</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.v6i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/18850/7772</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Nusantara Medical Science Journal</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>