Melola Discovery

← Melola Discovery

Open access Jurnal

Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother

Nusantara Medical Science Journal · Vol. ume (2024) · pp. 36–43

DOI
10.20956/nmsj.vi.20242
ISSN
2597-7288, 2460-9757
Published
2024-11-02
Publisher
Faculty of Medicine, Hasanuddin University.
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

Introduction: Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.

Collaboration network of the authors

31 authors · 85 co-authorship links

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Hasanuddin University
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Syahrul RaufAffiliation unknown2
Kusrini KadarAffiliation unknown1
Nurul Fadhilah GaniAffiliation unknown1
Huswatun HasanahAffiliation unknown1
Yolanda ManuleAffiliation unknown1
Risma MaharaniAffiliation unknown1
Zainab AzisAffiliation unknown1
M. Husni CangaraAffiliation unknown1
Syarifuddin WahidAffiliation unknown1
Nita MarianaAffiliation unknown1
Upik A. MiskadAffiliation unknown1
Prihantono PrihantonoAffiliation unknown1
Aussie Fitriani GhaznawieAffiliation unknown1
Akhtar Fajar MuzakkirAffiliation unknown1
F. FathlinaAffiliation unknown1
Ali Aspar MappahyaAffiliation unknown1
Abdul Hakim AlkatiriAffiliation unknown1
Idar MappangaraHasanuddin University1
Zaenab DjafarAffiliation unknown1
Muzakkir AmirAffiliation unknown1
Andi Muhammad Akram KastiranAffiliation unknown1
Melda WarlianiAffiliation unknown1
Rini Rachmawarni BachtiarAffiliation unknown1
Rahmawati Minhajat1Affiliation unknown1
Sri JayantiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother</dc:title>
	<dc:creator xml:lang="en">Kalatiku, Jane Magdalena</dc:creator>
	<dc:creator xml:lang="en">J Nelwan, Berti </dc:creator>
	<dc:creator xml:lang="en">Zainuddin, Andi Alfian </dc:creator>
	<dc:creator xml:lang="en">Kaelan, Cahyono </dc:creator>
	<dc:creator xml:lang="en">Achmad, Djumadi </dc:creator>
	<dc:creator xml:lang="en">Masadah, Rina </dc:creator>
	<dc:description xml:lang="en">



Introduction:  Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of  HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.



</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2024-11-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/20242</dc:identifier>
	<dc:identifier>10.20956/nmsj.vi.20242</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 8 Issue 2, July - December 2023; 36-43</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.vi</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/20242/12119</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Jane Magdalena Kalatiku, Berti  J Nelwan, Andi Alfian  Zainuddin, Cahyono  Kaelan, Djumadi  Achmad, Rina  Masadah</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>