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A Rare Case of Aplastic Anemia in Toxic Typhoid Fever

Nusantara Medical Science Journal · Vol. ume (2024) · hlm. 44–47

DOI
10.20956/nmsj.vi.32595
ISSN
2597-7288, 2460-9757
Terbit
2024-06-08
Penerbit
Faculty of Medicine, Hasanuddin University.
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Introduction and importance: Typhoid fever is one of the representative febrile diseases in the tropics, with unhygienic environmental conditions and poor public health systems. Pancytopenia from hemophagocytic lymphohistiocytosis is a rare complication of typhoid fever, which may be fatal if untreated. Presentation of case: A 20-year-old woman presented to our tertiary care center with high-grade fever, body pain, and slurring of speech. Investigations showed pancytopenia, TUBEX IgM Salmonella test positive, lymphadenopathy, and peripheral blood smear showed aplastic anemia after ruling out other possibilities and diagnostics. The patient responded to culture-sensitive antibiotics, steroids, and supportive care. Discussion: Pancytopenia in typhoid fever patients is linked to the mechanism of HLH (Hemophagocytic lymphohistiocytosis). Conclusion: It is essential to diagnose and treat toxic typhoid fever with an appropriate antibiotic to prevent complications.

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  • State University of Semarang
  • Sultan Agung Islamic University
  • Mulawarman University
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Rekan penulisOrganisasiArtikel bersama
Henky Yoga PrasetyaAfiliasi tidak diketahui1
Abdul HakamAfiliasi tidak diketahui1
Alek JusranAfiliasi tidak diketahui1
Muhamad IrsamAfiliasi tidak diketahui1
Widya Hary CahyatiState University of Semarang1
Dina Nur Anggraini NingrumState University of Semarang1
Casmuti CasmutiState University of Semarang1
Intan ZainafreeState University of Semarang1
Muhamad Zakki SaefurrohimMulawarman University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jmednus/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">A Rare Case of Aplastic Anemia in Toxic Typhoid Fever</dc:title>
	<dc:creator xml:lang="en">NOVITA, MUTIARA PUTRI NOVITA</dc:creator>
	<dc:creator xml:lang="en">Zaimatuddunia, Irma</dc:creator>
	<dc:description xml:lang="en">Introduction and importance: Typhoid fever is one of the representative febrile diseases in the tropics, with unhygienic environmental conditions and poor public health systems. Pancytopenia from hemophagocytic lymphohistiocytosis is a rare complication of typhoid fever, which may be fatal if untreated. Presentation of case: A 20-year-old woman presented to our tertiary care center with high-grade fever, body pain, and slurring of speech. Investigations showed pancytopenia, TUBEX IgM Salmonella test positive, lymphadenopathy, and peripheral blood smear showed aplastic anemia after ruling out other possibilities and diagnostics. The patient responded to culture-sensitive antibiotics, steroids, and supportive care. Discussion: Pancytopenia in typhoid fever patients is linked to the mechanism of HLH (Hemophagocytic lymphohistiocytosis). Conclusion: It is essential to diagnose and treat toxic typhoid fever with an appropriate antibiotic to prevent complications.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Hasanuddin University.</dc:publisher>
	<dc:date>2024-06-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jmednus/article/view/32595</dc:identifier>
	<dc:identifier>10.20956/nmsj.vi.32595</dc:identifier>
	<dc:source xml:lang="en">Nusantara Medical Science Journal; Volume 9 Issue 1, January - June 2024; 44-47</dc:source>
	<dc:source>2597-7288</dc:source>
	<dc:source>2460-9757</dc:source>
	<dc:source>10.20956/nmsj.vi</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jmednus/article/view/32595/12271</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 MUTIARA PUTRI NOVITA NOVITA, Irma Zaimatuddunia</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>