Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

Anita, Anita; Arisanti, Dewi; Fatmawati, Andi

doi:10.70561/jal.v9i2.5377

Jurnal

Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

Jurnal Ilmu Alam dan Lingkungan · Vol. 9 No. 2 (2018)

DOI: 10.70561/jal.v9i2.5377
ISSN: 2549-8819, 2086-4604
Terbit: 2018-11-12
Penerbit: Universitas Hasanuddin
Bahasa: en

Abstrak

There is high resistance cases for Isoniazid and Rifampin and more famous withMulti-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesishowed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases forfirstline-TB drugs (STR, INH, RIF,and ETH), and >2 resistance for secondline-TBdrugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrugresistanttuberculosis (MDR-TB) cases is very high.WHO recomended traditionalmedicine for improvement of healthy in coummunity, preventive and pharmaceuticalpreparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patientin South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)leaves estract as complement for TB drugs. Our study showed flavonoid component fromqualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleusatropurpereus) leaves estract.Qualitative method using Spektrofotometer UV-V showedthe total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leavesestract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,20%,40 %, 60 %,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leavesestract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were atconcentration (10%, 20%,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)leaves estract were not effecttively inhibit MDR-TB but effecttively were at concentration (80 % and 100%).

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Nur Haryanto	Afiliasi tidak diketahui	1
Rahmad Prajono	Afiliasi tidak diketahui	1
Awaludin Awaludin	Afiliasi tidak diketahui	1
Nurmaladewi Nurmaladewi	Universitas Halu Oleo	1
Wa Ode Salma	Universitas Halu Oleo	1
Mujahidah Basarang	Afiliasi tidak diketahui	1
Mardiah Mardiah	Afiliasi tidak diketahui	1
Eka Susanti	Afiliasi tidak diketahui	1
Galih Kartikasari	Afiliasi tidak diketahui	1
Anton Eko Satrio	Afiliasi tidak diketahui	1
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Nori Hariyen	Afiliasi tidak diketahui	1
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Nurul Silva Lestari	Afiliasi tidak diketahui	1
Antari Ayuning Arsi	Afiliasi tidak diketahui	1
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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jai2/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.

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	<dc:title xml:lang="en">Potentialy Of  Flavonoid Miana (Coleus Atropurpereus)  Leaves Estract   As  Anti  Mycobacterium Tuberculosis H37rv Strain And Mdr With   Microscopy Observation Drug Susceptibility (Mods)</dc:title>
	<dc:creator xml:lang="en">Anita, Anita</dc:creator>
	<dc:creator xml:lang="en">Arisanti, Dewi</dc:creator>
	<dc:creator xml:lang="en">Fatmawati, Andi</dc:creator>
	<dc:description xml:lang="en">There is high resistance cases for Isoniazid and Rifampin and more famous withMulti-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesishowed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases forfirstline-TB drugs (STR, INH, RIF,and ETH), and &amp;gt;2 resistance for secondline-TBdrugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrugresistanttuberculosis (MDR-TB) cases is very high.WHO recomended traditionalmedicine for improvement of healthy in coummunity, preventive and pharmaceuticalpreparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patientin South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)leaves estract as complement for TB drugs. Our study showed flavonoid component fromqualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleusatropurpereus) leaves estract .Qualitative method using Spektrofotometer UV-V showedthe total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leavesestract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,20% ,40 % , 60 % ,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leavesestract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were atconcentration (10%, 20% ,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)leaves estract were not effecttively inhibit MDR-TB but effecttively were at concentration (80 % and 100%).</dc:description>
	<dc:publisher xml:lang="en">Universitas Hasanuddin</dc:publisher>
	<dc:date>2018-11-12</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jai2/article/view/5377</dc:identifier>
	<dc:identifier>10.70561/jal.v9i2.5377</dc:identifier>
	<dc:source xml:lang="en">Jurnal Ilmu Alam dan Lingkungan; Vol. 9 No. 2 (2018): Jurnal Ilmu Alam dan Lingkungan</dc:source>
	<dc:source>2549-8819</dc:source>
	<dc:source>2086-4604</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jai2/article/view/5377/2913</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2018 Jurnal Ilmu Alam dan Lingkungan</dc:rights>
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