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Polimorfisme Gen Glutamylcysteine Ligase Catalytic (GCLC) Sebagai Deteksi Kerentanan Pasien Tuberkulosis Terhadap Stres Oksidatif Akibat Infeksi Mycobacterium tuberculosis

Jurnal Ilmu Alam dan Lingkungan · Vol. 12 No. 1 (2021)

DOI
10.70561/jal.v12i1.13097
ISSN
2549-8819, 2086-4604
Published
2021-03-01
Publisher
Universitas Hasanuddin
Language
en

Abstract

The important genetic factor about susceptibility of oxidative stress in Pulmonary Tuberculosis (PTB) has not been determined. The aim of this study was to analyse the association between polymorphism glutamatecysteine ligase catalytic subunit (GCLC) genes with susceptibility of oxidative stress in PTB in Makassar population of Indonesian. The Methods use is a case-control study was performed on 25 paired subjects with or without PTB, These subjects were selected from result of BTA stain from sputum subjects. The following polymorphisms were genotyped by PCR-RFLP of −129C/T in the GCLC gene. Genotype frequencies and allelic frequencies were analysed. The Results was found There were significant differences in the distribution of genotype frequencies for polymorphism −129C/T in GCLC gene between PTB and non-PTB subjects. The distribution of the allelic frequencies of these genes also showed significant difference between the two groups. Conclusions is The genetic polymorphisms in GCLC −129C/T are associated with susceptibility of Oxidative stress on PTP subject.

Collaboration network of the authors

40 authors · 111 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Eva JohannesAffiliation unknown3
Magdalena LitaayAffiliation unknown2
Slamet SantosaAffiliation unknown2
Willem MokaAffiliation unknown2
Ahyar AhmadAffiliation unknown2
Sartini SartiniAffiliation unknown1
Yenti PurnamasariAffiliation unknown1
Faisal AttamimiAffiliation unknown1
M Natsir DjideAffiliation unknown1
Muhammad Subhan A. SibaduAffiliation unknown1
Nurul Muhlisa MusAffiliation unknown1
Jennyta Dhewi Darmansyah TanjungAffiliation unknown1
Jennyta Dhewi Darmansyah TanjungAffiliation unknown1
Sjafaraenan SjafaraenanAffiliation unknown1
Handayani LolodatuAffiliation unknown1
Arfan SabranAffiliation unknown1
Andi Arfan SabranAffiliation unknown1
Mochammad HattaAffiliation unknown1
Mustika SariUniversitas Halu Oleo1
Nikmatia LatiefAffiliation unknown1
Muhammad ArsyadUniversitas Halu Oleo1
Amin NurAffiliation unknown1
Yunus MusaAffiliation unknown1
Burhanuddin RasyidAffiliation unknown1
Muh. JayadiAffiliation unknown1
Abd. Haris BahrunAffiliation unknown1
Muhammad Fuad AnshoriAffiliation unknown1
Achmad Kautsar BaharuddinAffiliation unknown1
Andi Nur AsrinawatyAffiliation unknown1
Rizalinda SjahrilAffiliation unknown1
Rusdianto RusdiantoAffiliation unknown1
Lokita PurnamasariAffiliation unknown1
Fahruddin FahruddinSunan Kalijaga State Islamic University Yogyakarta1
Zaraswati DwyanaAffiliation unknown1
Muh Ruslan UmarAffiliation unknown1
Moh. Ivan AzisAffiliation unknown1
Nur Haedar Nur HaedarAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jai2/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Polimorfisme Gen Glutamylcysteine Ligase Catalytic (GCLC) Sebagai Deteksi Kerentanan Pasien Tuberkulosis Terhadap Stres Oksidatif Akibat Infeksi Mycobacterium tuberculosis</dc:title>
	<dc:creator xml:lang="en">Andi Zulkifli AS</dc:creator>
	<dc:creator xml:lang="en">Muh. Nasrum Massi</dc:creator>
	<dc:creator xml:lang="en">Rosana Agus</dc:creator>
	<dc:description xml:lang="en">The important genetic factor about susceptibility of oxidative stress in Pulmonary Tuberculosis (PTB) has not been determined. The aim of this study was to analyse the association between polymorphism glutamatecysteine ligase catalytic subunit (GCLC) genes with susceptibility of oxidative stress in PTB in Makassar population of Indonesian. The Methods use is a case-control study was performed on 25 paired subjects with or without PTB, These subjects were selected from result of BTA stain from sputum subjects. The following polymorphisms were genotyped by PCR-RFLP of −129C/T in the GCLC gene. Genotype frequencies and allelic frequencies were analysed. The Results was found There were significant differences in the distribution of genotype frequencies for polymorphism −129C/T  in GCLC gene between PTB and non-PTB subjects. The distribution of the allelic frequencies of these genes also showed significant difference between the two groups. Conclusions is The genetic polymorphisms in GCLC −129C/T are associated with susceptibility of Oxidative stress on PTP subject.</dc:description>
	<dc:publisher xml:lang="en">Universitas Hasanuddin</dc:publisher>
	<dc:date>2021-03-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jai2/article/view/13097</dc:identifier>
	<dc:identifier>10.70561/jal.v12i1.13097</dc:identifier>
	<dc:source xml:lang="en">Jurnal Ilmu Alam dan Lingkungan; Vol. 12 No. 1 (2021): Jurnal Ilmu Alam dan Lingkungan</dc:source>
	<dc:source>2549-8819</dc:source>
	<dc:source>2086-4604</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jai2/article/view/13097/6554</dc:relation>
</oai_dc:dc>