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Dose Analysis in Boron Neutron Capture Therapy on Prostate Cancer using PHITS Program Version 3.32

Jurnal Penelitian Pendidikan · Vol. 42 No. 2 (2025) · hlm. 418–429

DOI
10.15294/jpp.v42i2.34883
ISSN
2580-4154, 2503-1260
Terbit
2025-10-31
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Prostate cancer is the second most common cancer in male worldwide. Boron Neutron Capture Therapy (BNCT) offers cancer treatment with minimum side effects. BNCT is radiation therapy that uses the 10B isotope and neutron beams which can selectively destroy tumor cells. The resulting radiation dose cannot be measured directly, so a computational method is needed to calculate the dose. The aim of this research is to determine the effective boron concentration, determine the optimal direction of irradiation, and determine the duration of irradiation time at an effective boron concentration for BNCT of prostate cancer. The computational method used is the Monte Carlo method with PHITS Version 3.32 software. The phantom used is an adult male ORNL phantom. The type of prostate cancer modeled is adenocarcinoma with an intermediate risk group. The neutron source is a 30 MeV cyclotron. Variations in 10B concentrations used were 100, 110, 120, 130, 140, and 150 µg/g boron/cancer tissue. The variations in direction used are: anterior-posterior, lateral-anterior oblique, and left-lateral. This study yield that the effective boron concentration used for BNCT in prostate cancer is 150 µg/g boron/cancer tissue. The most optimal radiation direction for BNCT of prostate cancer is the anterior-posterior direction. The duration of irradiation time required for a boron concentration of 150 µg/g boron/cancer tissue is 1 hour 16 minutes 10 seconds.

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  • State University of Semarang
  • Universitas PGRI Semarang
  • Universitas Islam Negeri Sultan Syarif Kasim Riau
  • National University of Laos
  • Universitas Halu Oleo
  • Universitas Ahmad Dahlan
  • Satya Wacana Christian University
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Rekan penulisOrganisasiArtikel bersama
Dwi YuliantiState University of Semarang5
Ian YuliantiAfiliasi tidak diketahui4
Bambang SubaliAfiliasi tidak diketahui3
Sri IsdadiyantoAfiliasi tidak diketahui3
La Ode Irman JayaAfiliasi tidak diketahui3
Sunyoto Eko NugrohoState University of Semarang3
Ellianawati EllianawatiState University of Semarang3
Sarwi SarwiAfiliasi tidak diketahui3
Hartono HartonoAfiliasi tidak diketahui3
Wahyu HardyantoAfiliasi tidak diketahui2
Emi Shofiyatul KhusnaAfiliasi tidak diketahui2
Kustopo BudiraharjoAfiliasi tidak diketahui2
Wiyanto WiyantoState University of Semarang2
Khumaedi KhumaediAfiliasi tidak diketahui2
Susilo SusiloAfiliasi tidak diketahui2
Langlang HandayaniAfiliasi tidak diketahui2
Wiwi IsnaeniState University of Semarang2
Ani RusilowatiState University of Semarang2
Nur KhoiriUniversitas PGRI Semarang1
S. SusilawatiUniversitas Islam Negeri Sultan Syarif Kasim Riau1
Wahyudi WijayantoUniversitas PGRI Semarang1
S. XaphakdyNational University of Laos1
Sahiruddin SahiruddinUniversitas Ahmad Dahlan1
Muhammad YusufUniversitas Halu Oleo1
Nur SalmahAfiliasi tidak diketahui1
Toleng Abd LatiefAfiliasi tidak diketahui1
Hasrin HasrinAfiliasi tidak diketahui1
Masir UmmulAfiliasi tidak diketahui1
Hanna Arini ParhusipSatya Wacana Christian University1
Suryasatriya TrihandaruAfiliasi tidak diketahui1
Isman Mulyadi TriatmokoAfiliasi tidak diketahui1
Gede Sutresna WijayaAfiliasi tidak diketahui1
Jane LabadinAfiliasi tidak diketahui1
Teguh DarsonoAfiliasi tidak diketahui1
Slamet HaryonoAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JPP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Dose Analysis in Boron Neutron Capture Therapy on Prostate Cancer using PHITS Program Version 3.32</dc:title>
	<dc:creator xml:lang="en"> Fernando, Rio Agustian Gilang</dc:creator>
	<dc:creator xml:lang="en">Dwijananti, Pratiwi </dc:creator>
	<dc:creator xml:lang="en">Masturi, Masturi</dc:creator>
	<dc:creator xml:lang="en">Sunarno, Sunarno</dc:creator>
	<dc:creator xml:lang="en">Sardjono, Yohannes </dc:creator>
	<dc:subject xml:lang="en">BNCT</dc:subject>
	<dc:subject xml:lang="en">dosimetry</dc:subject>
	<dc:subject xml:lang="en">PHITS</dc:subject>
	<dc:subject xml:lang="en">prostate cancer</dc:subject>
	<dc:description xml:lang="en">Prostate cancer is the second most common cancer in male worldwide. Boron Neutron Capture Therapy (BNCT) offers cancer treatment with minimum side effects. BNCT is radiation therapy that uses the 10B isotope and neutron beams which can selectively destroy tumor cells. The resulting radiation dose cannot be measured directly, so a computational method is needed to calculate the dose. The aim of this research is to determine the effective boron concentration, determine the optimal direction of irradiation, and determine the duration of irradiation time at an effective boron concentration for BNCT of prostate cancer. The computational method used is the Monte Carlo method with PHITS Version 3.32 software. The phantom used is an adult male ORNL phantom. The type of prostate cancer modeled is adenocarcinoma with an intermediate risk group. The neutron source is a 30 MeV cyclotron. Variations in 10B concentrations used were 100, 110, 120, 130, 140, and 150 µg/g boron/cancer tissue. The variations in direction used are: anterior-posterior, lateral-anterior oblique, and left-lateral. This study yield that the effective boron concentration used for BNCT in prostate cancer is 150 µg/g boron/cancer tissue. The most optimal radiation direction for BNCT of prostate cancer is the anterior-posterior direction. The duration of irradiation time required for a boron concentration of 150 µg/g boron/cancer tissue is 1 hour 16 minutes 10 seconds.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JPP/article/view/34883</dc:identifier>
	<dc:identifier>10.15294/jpp.v42i2.34883</dc:identifier>
	<dc:source xml:lang="en">Jurnal Penelitian Pendidikan; Vol. 42 No. 2 (2025): October 2025; 418-429</dc:source>
	<dc:source>2580-4154</dc:source>
	<dc:source>2503-1260</dc:source>
	<dc:source>10.15294/jpp.v42i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JPP/article/view/34883/6406</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jurnal Penelitian Pendidikan</dc:rights>
</oai_dc:dc>