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Comparison of Eco - Scale Between UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry Methods on The Determinination of Retinoic Acid in Facial Cream Preparations

Journal of Science and Technology Research for Pharmacy · Vol. 4 No. 1 (2025) · hlm. 15–21

DOI
10.15294/jstrp.v4i1.5415
ISSN
2776-0685
Terbit
2025-07-10
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Retinoic acid, a compound derived from vitamin A and its active metabolites, is often found in cream preparations and can be used without a doctor's prescription. This research aims to analyze the retinoic acid content in facial cream preparations and determine the environmental friendliness of the analytical method used. The materials used in this research were PBFI retinoic acid, methanol, TLC plates, n-hexane, acetone, and three facial cream samples. UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry are methods used for assay analysis and Eco - Scale is a method for determining greenness. The research found that three cream samples tested positive for retinoic acid, which has been banned by BPOM since 1999. The UV-Vis Spectrophotometry method measured retinoic acid content of 0.103%, 0.266% and 0.256%, with a total score of 24 points. The Thin Layer Chromatography - Densitometry method measured retinoic acid content of 0.0213%, 0.0314%, and 0.027%, with a score of 50 points. It can be concluded that the UV - Vis Spectrophotometry method is more environmentally friendly compared to the Thin Layer Chromatography - Densitometry method based on Eco - Scale analysis.

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  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Anida Hasna RahmatikaState University of Semarang1
Sistia Asfa FiqrotinnisaState University of Semarang1
Hanifah Az-ZahraState University of Semarang1
Edy CahyonoState University of Semarang1
Dante AlighiriState University of Semarang1
Tri HandayaniState University of Semarang1
Sabila AisyahState University of Semarang1
Bella PermatasariState University of Semarang1
Nugrahaningsih WHState University of Semarang1
Adrian Maulana ZakyState University of Semarang1
Monica AvissaState University of Semarang1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Comparison of Eco - Scale Between UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry Methods on The Determinination of Retinoic Acid in Facial Cream Preparations</dc:title>
	<dc:creator xml:lang="en">Nur Faida, Zaneta</dc:creator>
	<dc:creator xml:lang="en">Mohammad Alauhdin</dc:creator>
	<dc:subject xml:lang="en">Eco – Scale </dc:subject>
	<dc:subject xml:lang="en">UV – Vis Spectrophotometry</dc:subject>
	<dc:subject xml:lang="en">Thin Layer Chromatography – Densitometry</dc:subject>
	<dc:subject xml:lang="en">Retinoic Acid</dc:subject>
	<dc:subject xml:lang="en">Facial Cream</dc:subject>
	<dc:description xml:lang="en">Retinoic acid, a compound derived from vitamin A and its active metabolites, is often found in cream preparations and can be used without a doctor's prescription. This research aims to analyze the retinoic acid content in facial cream preparations and determine the environmental friendliness of the analytical method used. The materials used in this research were PBFI retinoic acid, methanol, TLC plates, n-hexane, acetone, and three facial cream samples. UV - Vis Spectrophotometry and Thin Layer Chromatography - Densitometry are methods used for assay analysis and Eco - Scale is a method for determining greenness. The research found that three cream samples tested positive for retinoic acid, which has been banned by BPOM since 1999. The UV-Vis Spectrophotometry method measured retinoic acid content of 0.103%, 0.266% and 0.256%, with a total score of 24 points. The Thin Layer Chromatography - Densitometry method measured retinoic acid content of 0.0213%, 0.0314%, and 0.027%, with a score of 50 points. It can be concluded that the UV - Vis Spectrophotometry method is more environmentally friendly compared to the Thin Layer Chromatography - Densitometry method based on Eco - Scale analysis.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/5415</dc:identifier>
	<dc:identifier>10.15294/jstrp.v4i1.5415</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 4 No. 1 (2024): Journal of Science and Technology Research for Pharmacy; 15-21</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/5415/4340</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>