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Antimicrobial Activity of Ethanol Extract of Cucumber (Cucumis Sativus L.) Peels and Formulation as Anti-Acne Cream

Journal of Science and Technology Research for Pharmacy · Vol. 3 No. 2 (2025) · hlm. 1–9

DOI
10.15294/jstrp.v3i2.9043
ISSN
2776-0685
Terbit
2025-06-05
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Background: Cucumber is proven to have pharmacological activities as antimicrobial. Some of the secondary metabolites contained in cucumber fruit have antimicrobial activity. Aim: This study aims to determine the antibacterial activity of ethanol extract of cucumber peels against Staphylococcus epidermidis and to make anti-acne cream using cucumber skin extract. Material and Methods: The extraction of cucumber peels extract with maceration using 96% ethanol solvent. Phytochemical screening to determine the compounds contained in the extract. The antibacterial activity test of the extract was carried out through liquid and solid dilution methods to determine the MIC and MBC values. The extract was then made into a cream with varying concentrations of stearic acid and TEA as an emulsifier and then evaluated and tested for antibacterial activity using the agar diffusion method. Results: Cucumber peels extract contains steroids, alkaloids, flavonoids, phenols, and saponins that have antibacterial activity against Staphylococcus epidermidis with an MIC value of 2.5% and an MBC value of 5%. The results of the cream evaluation test show that formula F(3) is the most optimal formula for inhibiting Staphylococcus epidermidis bacteria with a cucumber skin concentration content of 4.5%. The antibacterial activity test has an inhibition zone of 33-52.70 mm with a very strong category.

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  • State University of Semarang
  • Universitas Indraprasta PGRI
  • Universitas Nahdlatul Ulama Blitar
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Rekan penulisOrganisasiArtikel bersama
Dewi MustikaningtyasAfiliasi tidak diketahui11
Pramesti DewiAfiliasi tidak diketahui8
Ibnul MubarokAfiliasi tidak diketahui7
Retno Sri IswariState University of Semarang3
R. SusantiAfiliasi tidak diketahui3
Saiful RidloState University of Semarang3
Talitha WidiatningrumAfiliasi tidak diketahui2
Siti AlimahState University of Semarang2
Sri SukaesihState University of Semarang2
Dwi Puji HayatiAfiliasi tidak diketahui2
Mutiara Bintang RamadaniAfiliasi tidak diketahui1
Astrid FarmayatiAfiliasi tidak diketahui1
Lusi Maswahyu AndriyaniAfiliasi tidak diketahui1
SunyotoAfiliasi tidak diketahui1
Nana Kariada Tri MartutiState University of Semarang1
Fitria Ayu TirtaningrumAfiliasi tidak diketahui1
Lidya Ayu NataliaAfiliasi tidak diketahui1
Ruri WinantiAfiliasi tidak diketahui1
Fahmi RahmawatiAfiliasi tidak diketahui1
Anis MaftuhahAfiliasi tidak diketahui1
Septi JayantiAfiliasi tidak diketahui1
Anisa Ratna NugrainiAfiliasi tidak diketahui1
Nihayatul MilahAfiliasi tidak diketahui1
Saeful AnhariAfiliasi tidak diketahui1
Dwi SusilaningsihAfiliasi tidak diketahui1
Aulia Nuanza AlamAfiliasi tidak diketahui1
Nikmatul HidayahAfiliasi tidak diketahui1
Sri UtamiUniversitas Indraprasta PGRI1
Yenni Tyas Wulandari K. EAfiliasi tidak diketahui1
Afra Fauziah L. PutriAfiliasi tidak diketahui1
Nadya Audina Nurkhafiya SadikinAfiliasi tidak diketahui1
Lulu Dar Zulfatunna’imAfiliasi tidak diketahui1
Anisa Rahmawati PutriAfiliasi tidak diketahui1
Isnaeni Karunia AnnisaAfiliasi tidak diketahui1
Fitri AndiniyatiAfiliasi tidak diketahui1
Sugianto SugiantoUniversitas Nahdlatul Ulama Blitar1
Dwi YuliantiState University of Semarang1
Tri Sri Noor AsihAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Antimicrobial Activity of Ethanol Extract of Cucumber (Cucumis Sativus L.) Peels and Formulation as Anti-Acne Cream</dc:title>
	<dc:creator xml:lang="en">Ramadhani, Nadya Wulan</dc:creator>
	<dc:creator xml:lang="en">Bintari, Siti Harnina </dc:creator>
	<dc:subject xml:lang="en">Cucumber peels</dc:subject>
	<dc:subject xml:lang="en">Antibacterial</dc:subject>
	<dc:subject xml:lang="en">staphylococcus epidermidis</dc:subject>
	<dc:subject xml:lang="en">anti-acne cream</dc:subject>
	<dc:description xml:lang="en">Background: Cucumber is proven to have pharmacological activities as antimicrobial. Some of the secondary metabolites contained in cucumber fruit have antimicrobial activity. Aim: This study aims to determine the antibacterial activity of ethanol extract of cucumber peels against Staphylococcus epidermidis and to make anti-acne cream using cucumber skin extract. Material and Methods: The extraction of cucumber peels extract with maceration using 96% ethanol solvent. Phytochemical screening to determine the compounds contained in the extract. The antibacterial activity test of the extract was carried out through liquid and solid dilution methods to determine the MIC and MBC values. The extract was then made into a cream with varying concentrations of stearic acid and TEA as an emulsifier and then evaluated and tested for antibacterial activity using the agar diffusion method. Results: Cucumber peels extract contains steroids, alkaloids, flavonoids, phenols, and saponins that have antibacterial activity against Staphylococcus epidermidis with an MIC value of 2.5% and an MBC value of 5%. The results of the cream evaluation test show that formula F(3) is the most optimal formula for inhibiting Staphylococcus epidermidis bacteria with a cucumber skin concentration content of 4.5%. The antibacterial activity test has an inhibition zone of 33-52.70 mm with a very strong category.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-06-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/9043</dc:identifier>
	<dc:identifier>10.15294/jstrp.v3i2.9043</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy; 1-9</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/9043/4334</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>