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Optimization of The Concentration of Precipitation Reagent in Cyclamate Analysis and Determination of Cyclamate Contents in Jamu

Journal of Science and Technology Research for Pharmacy · Vol. 3 No. 2 (2025) · hlm. 20–27

DOI
10.15294/jstrp.v3i2.9329
ISSN
2776-0685
Terbit
2025-07-10
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

: Sodium cyclamate is one of the food additives sweeteners that are often added to food products including jamu. It has a low price and a taste 30 - 50 times sweeter than natural sugar. It is known that excessive & longterm use of sodium cyclamate can cause adverse health effects. Currently, the standard method used to detect the presence of cyclamate refers to the precipitation method of SNI 01-2893. However, the level of sensitivity of the method is unknown. This study aims to determine the sensitivity of the precipitation method of SNI 01-2893, as well as to optimize reagents that have better sensitivity to be used as a reference for cyclamate precipitation reagents and applied to measure cyclamate in jamu. The determination the method’s sensitivity is based on the smallest concentration of cyclamate standard that can be detected by the method. Optimization of the precipitation reagent was carried out on 6 variations of precipitation reagent concentration to obtain a new formula that has a better sensitivity than the SNI 01-2893 method. Jamu samples were tested using the new optimized reagent formula. The result showed the detection limit of the of SNI 01-2893 method is 5 ppm. Optimization of the precipitation reagent formula with the composition of HCl 10%, BaCl2 10%, and NaNO2 20% showed as the highest sensitivity. It was marked by an increase in the amount of precipitate formed and had a detection limit of up to 0.9 ppm. Based on testing using the new reagent, 9 out of 10 jamu samples were positive for cyclamate. The cyclamate levels of the 9 jamu samples were measured using the spectrophotometric method, the results showed cyclamate levels are in the range of 4.3 - 6.32 mg/kg sample and meeting BPOM requirements.

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  • State University of Semarang
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Agung Tri PrasetyaState University of Semarang5
Eko Budi SusatyoAfiliasi tidak diketahui3
Wisnu SunartoAfiliasi tidak diketahui2
Charisma ChalifAfiliasi tidak diketahui1
Zaneta Nur FaidaAfiliasi tidak diketahui1
Anida Hasna RahmatikaAfiliasi tidak diketahui1
Agus SuciptoAfiliasi tidak diketahui1
Wahida RahmawatiAfiliasi tidak diketahui1
Hanifah -Afiliasi tidak diketahui1
Fadila IskandarAfiliasi tidak diketahui1
HarjonoState University of Semarang1
F. ‪Widhi MahatmantiAfiliasi tidak diketahui1
Riska Putri MawarniAfiliasi tidak diketahui1
Hanifah Az-ZahraAfiliasi tidak diketahui1
Erwin Budi PamungkasAfiliasi tidak diketahui1
Gayuh Ganata Imam SofyanAfiliasi tidak diketahui1
Riera Asti WulaningrumAfiliasi tidak diketahui1
Himnil KhusnaAfiliasi tidak diketahui1
Novilla AnggasariAfiliasi tidak diketahui1
Winarni PratjojoAfiliasi tidak diketahui1
Arfah Ratna Puri GustianAfiliasi tidak diketahui1
Ervina Nur HidayatiAfiliasi tidak diketahui1
Nova Shintia BokauAfiliasi tidak diketahui1
Dyah SetyaningrumAfiliasi tidak diketahui1
Aurelia Anggit Widya MunikaAfiliasi tidak diketahui1
Endang SusilaningsihState University of Semarang1
Zumrotus Sa’adahAfiliasi tidak diketahui1
Suryat Hadi KusumaAfiliasi tidak diketahui1
Amallia KurniawatiAfiliasi tidak diketahui1
Puji RizqiAfiliasi tidak diketahui1
Nydia Ashfi AuhaAfiliasi tidak diketahui1
Nuril HudaAfiliasi tidak diketahui1
Ridho PrasetyoAfiliasi tidak diketahui1
Martin SulistyaniAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Optimization of The Concentration of Precipitation Reagent in Cyclamate Analysis and Determination of Cyclamate Contents in Jamu</dc:title>
	<dc:creator xml:lang="en">Sistia Asfa Fiqrotinnisa</dc:creator>
	<dc:creator xml:lang="en">Mohammad Alauhdin</dc:creator>
	<dc:subject xml:lang="en">Jamu</dc:subject>
	<dc:subject xml:lang="en">Precipitation Method</dc:subject>
	<dc:subject xml:lang="en">Sodium Cyclamate</dc:subject>
	<dc:description xml:lang="en">: Sodium cyclamate is one of the food additives sweeteners that are often added to food products including jamu. It has a low price and a taste 30 - 50 times sweeter than natural sugar. It is known that excessive &amp;amp; longterm use of sodium cyclamate can cause adverse health effects. Currently, the standard method used to detect the presence of cyclamate refers to the precipitation method of SNI 01-2893. However, the level of sensitivity of the method is unknown. This study aims to determine the sensitivity of the precipitation method of SNI 01-2893, as well as to optimize reagents that have better sensitivity to be used as a reference for cyclamate precipitation reagents and applied to measure cyclamate in jamu. The determination the method’s sensitivity is based on the smallest concentration of cyclamate standard that can be detected by the method. Optimization of the precipitation reagent was carried out on 6 variations of precipitation reagent concentration to obtain a new formula that has a better sensitivity than the SNI 01-2893 method. Jamu samples were tested using the new optimized reagent formula. The result showed the detection limit of the of SNI 01-2893 method is 5 ppm. Optimization of the precipitation reagent formula with the composition of HCl 10%, BaCl2 10%, and NaNO2 20% showed as the highest sensitivity. It was marked by an increase in the amount of precipitate formed and had a detection limit of up to 0.9 ppm. Based on testing using the new reagent, 9 out of 10 jamu samples were positive for cyclamate. The cyclamate levels of the 9 jamu samples were measured using the spectrophotometric method, the results showed cyclamate levels are in the range of 4.3 - 6.32 mg/kg sample and meeting BPOM requirements.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/9329</dc:identifier>
	<dc:identifier>10.15294/jstrp.v3i2.9329</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy; 20-27</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/9329/4338</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>