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Formulation of Peel-Off Gel Mask From Manilkara Zapota (L) P. Royen Leaves Extract and Antibacterial Activity Against

Journal of Science and Technology Research for Pharmacy · Vol. 3 No. 2 (2025) · pp. 38–49

DOI
10.15294/jstrp.v3i2.9891
ISSN
2776-0685
Published
2025-07-10
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Sawo leaves contain alkaloids, flavonoids, tannins, saponins and steroids which are antibacterial. This study aims to obtain the best concentration of Sawo leaf ethanol extract (Manilkara zapota (L) P. Royen) formulated as a peel-off gel mask preparation based on antibacterial activity test against Staphylococcus epidermidis bacteria. This study used laboratory experimental method. Sawo leaf extract peel-off gel mask preparation formula was made with concentration variations of 0.1%; 0.3%; 0.6%; 2.5%; 5% and 10%. Sawo leaf plant extract was obtained by maceration using 96% ethanol solvent. Identification of compounds was carried out using phytochemical screening, spray TLC and Bioautography TLC. Antibacterial testing of extracts was carried out using solid dilution and liquid dilution methods. The antibacterial test of the preparation using the wells diffusion method had the largest diameter of the inhibition zone at a concentration of 8% with an inhibition zone diameter of 14.1 mm and the inhibition ability was categorized as strong. It can be concluded that the concentration of 2%; 4%; 6%; 8% is good to be formulated as a peel-off gel mask preparation and is categorized as strong inhibition ability.

Keywords

Collaboration network of the authors

10 authors · 15 co-authorship links

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Co-authorOrganisationJoint articles
Tristania Magdalena DumatubunAffiliation unknown1
Thianika Shalsabillah ArmandokoAffiliation unknown1
Nabila Meilani DewiAffiliation unknown1
Arneta EvaniaAffiliation unknown1
R. SusantiAffiliation unknown1
Wulan ChristijantiAffiliation unknown1
Kartika WidyaningrumAffiliation unknown1
Mohd Salim Bin MohamedAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/JSTRP/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Formulation of Peel-Off Gel Mask From Manilkara Zapota (L) P. Royen Leaves Extract and Antibacterial Activity Against</dc:title>
	<dc:creator xml:lang="en">K Syifa Fauziyah</dc:creator>
	<dc:creator xml:lang="en">Senda Kartika Rakainsa</dc:creator>
	<dc:subject xml:lang="en">Antibacterial</dc:subject>
	<dc:subject xml:lang="en">Peel Off Gel Mask</dc:subject>
	<dc:subject xml:lang="en">Sawo (Manilkara zapota (L) P. Royen)</dc:subject>
	<dc:subject xml:lang="en">Staphylococcus epidermidis</dc:subject>
	<dc:subject xml:lang="en">TLC bioautography</dc:subject>
	<dc:description xml:lang="en">Sawo leaves contain alkaloids, flavonoids, tannins, saponins and steroids which are antibacterial. This study aims to obtain the best concentration of Sawo leaf ethanol extract (Manilkara zapota (L) P. Royen) formulated as a peel-off gel mask preparation based on antibacterial activity test against Staphylococcus epidermidis bacteria. This study used laboratory experimental method. Sawo leaf extract peel-off gel mask preparation formula was made with concentration variations of 0.1%; 0.3%; 0.6%; 2.5%; 5% and 10%. Sawo leaf plant extract was obtained by maceration using 96% ethanol solvent. Identification of compounds was carried out using phytochemical screening, spray TLC and Bioautography TLC. Antibacterial testing of extracts was carried out using solid dilution and liquid dilution methods. The antibacterial test of the preparation using the wells diffusion method had the largest diameter of the inhibition zone at a concentration of 8% with an inhibition zone diameter of 14.1 mm and the inhibition ability was categorized as strong. It can be concluded that the concentration of 2%; 4%; 6%; 8% is good to be formulated as a peel-off gel mask preparation and is categorized as strong inhibition ability.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/JSTRP/article/view/9891</dc:identifier>
	<dc:identifier>10.15294/jstrp.v3i2.9891</dc:identifier>
	<dc:source xml:lang="en">Journal of Science and Technology Research for Pharmacy; Vol. 3 No. 2 (2023): Journal of Science and Technology Research for Pharmacy; 38-49</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/JSTRP/article/view/9891/4339</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>