Jurnal
Formulation and Antibacterial Activity Testing of Nanoemulsion Cream from Coriander Seed Extract (Coriandrum sativum L.) in Inhibiting Protein Synthesis of Staphylococcus aureus Bacteria
Journal of Science and Technology Research for Pharmacy · Vol. 5 No. 1 (2025) · hlm. 14–26
- ISSN
- 2776-0685
- Terbit
- 2025-07-25
- Penerbit
- Universitas Negeri Semarang
- Bahasa
- eng
Abstrak
Bullous impetigo is a contagious skin infection caused by Staphylococcus aureus, characterized by the formation of fluid-filled bullae. The use of topical antibiotics for impetigo treatment has side effects, including the increased risk of bacterial resistance, leading to reduced efficacy. Natural alternatives such as coriander seeds (Coriandrum sativum L.) have the potential as antibacterial agents with fewer side effects. This study aimed to formulate and evaluate the antibacterial activity of a nanoemulsion cream containing coriander seed extract against Staphylococcus aureus. The extraction of coriander seeds was carried out using the maceration method with 96% ethanol to obtain a thick extract, followed by phytochemical screening to qualitatively identify bioactive compounds and a quantitative total flavonoid test, which resulted in a flavonoid content of 61.64 mg QE/g. The nanoemulsion was formulated using PEG 400 and VCO as the oil phase, while Tween 80, distilled water, and coriander seed extract at concentrations of 2.5%, 5%, and 7.5% were used as the aqueous phase. The nanoemulsion was then incorporated into a cream base containing stearic acid, cera alba, and white vaseline as the oil phase, and TEA, propylene glycol, methylparaben, and distilled water as the aqueous phase, heated in a water bath at 75°C. The resulting preparations were evaluated and tested for antibacterial activity using the well diffusion method. The bioactive compounds identified in coriander seed extract include alkaloids, saponins, tannins, terpenoids, and flavonoids, which exhibit antibacterial activity against Staphylococcus aureus. The antibacterial test results showed that the inhibition zones for F1 (2.5%), F2 (5%), and F3 (7.5%) were 15.00 mm, 22.00 mm, and 28.33 mm, respectively, while the positive control had an inhibition zone of 30.67 mm. The highest antibacterial activity was obtained at the F3 concentration (7.5%) with an inhibition zone diameter of 28.33 mm, classified as very strong.
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- Institut Agama Islam Negeri Kendari
- State University of Semarang
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- Organisasi berbeda
- Organisasi sama
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Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Bertakalswa Hermawati | Afiliasi tidak diketahui | 3 |
| Jayanti Evananda Febrian | Afiliasi tidak diketahui | 2 |
| Yunita Dyah Puspita Santik | Afiliasi tidak diketahui | 2 |
| Fitri Indrawati | Afiliasi tidak diketahui | 2 |
| Anisa Fitri | Institut Agama Islam Negeri Kendari | 2 |
| Arvia Dhitya Maharhani | Afiliasi tidak diketahui | 2 |
| Devita Uzlah Sibarani | Afiliasi tidak diketahui | 1 |
| Sherly Gusnawan | Afiliasi tidak diketahui | 1 |
| Hermi Nur Laela | Afiliasi tidak diketahui | 1 |
| Arum Siwiendrayanti | State University of Semarang | 1 |
| Fitriana Puspitarani | Afiliasi tidak diketahui | 1 |
| Isnaningsih Isnaningsih | Afiliasi tidak diketahui | 1 |
| Fitriyana Fitriyana | Afiliasi tidak diketahui | 1 |
| Rudatin Windraswara | Afiliasi tidak diketahui | 1 |
| Annisa Arum Kartika Dewi | Afiliasi tidak diketahui | 1 |
| Atiya Inayah | Afiliasi tidak diketahui | 1 |
| Siti Yuliana Syafriati | Afiliasi tidak diketahui | 1 |
| Nila Kusumawati | Afiliasi tidak diketahui | 1 |
| Aswi Nur Syahbani | Afiliasi tidak diketahui | 1 |
| Ragil Andriani | Afiliasi tidak diketahui | 1 |
| Isnaini Alfazcha Zukhruf | Afiliasi tidak diketahui | 1 |
| Azizah Nur Abdillah | Afiliasi tidak diketahui | 1 |
| Afifah Maulidia Az Zahro' | Afiliasi tidak diketahui | 1 |
| Dela Putri Wulandari | Afiliasi tidak diketahui | 1 |
| Nanda Putri Dewanti | Afiliasi tidak diketahui | 1 |
| Siti Lailatin Nasifah | Afiliasi tidak diketahui | 1 |
| Ella Wahyu Irawan | Afiliasi tidak diketahui | 1 |
| Erna Zuliana Muanifah | Afiliasi tidak diketahui | 1 |
| Dwi Salsabilla Putri | Afiliasi tidak diketahui | 1 |
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