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The Role of Mesenchymal Stem Cell in Controlling Liver Function on Liver Fibrosis

Journal of Science and Technology Research for Pharmacy · Vol. 1 No. 2 (2021) · hlm. 42–47

DOI
10.15294/jstrp.v1i2.45699
ISSN
2776-0685
Terbit
2021-04-05
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

ABSTRACT Background: Liver fibrosis (LF) is the end-stage of liver damage characterized by the increase concentration of SGOT and SGPT. A previous study, revealed that liver transplantation as the most effective therapy for LF has limited availability and remains a major challenge. Mesenchymal stem may control inflammation and regenerate damaged tissue leading to accelerated liver function repair. Aim: The purpose of this study was to determine the optimum doze for MSC administration to recover LF. Method: The research used variations doze of MSCs administration of 1x106 and 2x106. Liver firbosis was induced by twice a week intraperitoneal injection of carbon tetrachloride (CCl4) (Sigma-Aldrich) dissolved with olive oil in 1:1 ratio for eight weeks. The concentration of SGPT SGOT was measured at day 9 post MSC administration. One Way Anova was performed to analyze statictical data. Result: This study showed that there was a significant decrease in SGOT concentration (P 0,05). Conclusion: The transplantation of MSCs ameliorated LF by reducing SGPT and SGOT concentration

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Role of Mesenchymal Stem Cell in Controlling Liver Function on Liver Fibrosis</dc:title>
	<dc:creator>Antari, Arini Dewi</dc:creator>
	<dc:creator>Prasetio, Ardi</dc:creator>
	<dc:creator>Nugroho, Baskoro Adi</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT
Background: Liver fibrosis (LF) is the end-stage of liver damage characterized by the increase concentration of SGOT and SGPT. A previous study, revealed that liver transplantation as the most effective therapy for LF has limited availability and remains a major challenge. Mesenchymal stem may control inflammation and regenerate damaged tissue leading to accelerated liver function repair.
Aim: The purpose of this study was to determine the optimum doze for MSC administration to recover LF.&amp;nbsp;
Method: The research used variations doze of MSCs administration of 1x106 and 2x106. Liver firbosis was induced by twice a week intraperitoneal injection of carbon tetrachloride (CCl4) (Sigma-Aldrich) dissolved with olive oil in 1:1 ratio for eight weeks. The concentration of SGPT SGOT was measured at day 9 post MSC administration. One Way Anova was performed to analyze statictical data.
Result: This study showed that there was a significant decrease in SGOT concentration (P &amp;lt; 0,05). P2 group treatment showed the lowest concentration of SGOT among the treatment (Figure B). In the same time, the administration of UC-MSCs reduce SGPT concentration insignificantly (P &amp;gt; 0,05).
Conclusion: The transplantation of MSCs ameliorated LF by reducing SGPT and SGOT concentration</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2021-04-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/JSTRP/article/view/45699</dc:identifier>
	<dc:identifier>10.15294/jstrp.v1i2.45699</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Science and Technology Research for Pharmacy; Vol 1 No 2 (2021); 42-47</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:source>10.15294/jstrp.v1i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/JSTRP/article/view/45699/20886</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>