Melola Discovery

← Melola Discovery

Jurnal

The Antibacterial Activity of Acanthus ilicifolius L. n-Hexane Fraction

Journal of Science and Technology Research for Pharmacy · Vol. 1 No. 2 (2022) · hlm. 48–56

DOI
10.15294/jstrp.v1i2.49615
ISSN
2776-0685
Terbit
2022-01-22
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Background: Recently, with the high prevalence of diarrhoea caused by bacterial infection, the usage of antibiotics has increased. Antibiotic overuse might lead to several side effects and resistance, suggesting the development of an alternate antibacterial agent. A mangrove plant, Acanthus Illinois, contained triterpenoid, which has antibacterial properties. Aim: This study aimed to evaluate the antibacterial effect of the Acanthus Illinois n-hexane fraction against Escherichia coli and Shigella dysenteriae. Method: The Acanthus Illinois was fraction using n-Hexane, identification of secondary metabolite compound using GC-MS, and evaluation of antibacterial activity against Escherichia coli and Shigella dysenteriae under paper disc methods. This study was designed using a fully randomized design (CRD) with concentrations of fractions 1%, 2%, and 4%. The GC-MS results were compared to the WILEY 9 library and analysed. A prism graph was used to measure the inhibition zone of antibacterial activity. Result: The n-hexane fraction yield is 3.3% and contains sesquiterpene compounds (trans (beta.)-caryophyllene, alpha humulene, naphthalene decahedron-4A-methyl), terpenoid alcohol (3,7,11,15-tetramethyl -2-hexadecane-1-ol), and fatty acids (hexadecanoic acid methyl ester. Acanthus Illinois n-hexane fraction has antibacterial activity against Escherichia coli and Shigella dysenteriae in a dose-dependent manner. Conclusion: The n-hexane fraction of leaves Acanthus ilicifolius contains sesquiterpene, alcohol terpenoids, and fatty, and has antibacterial activity against Escherichia coli and Shigella dysenteriae

Jaringan kolaborasi para penulis

32 penulis · 115 tautan kepenulisan bersama

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Jenderal Soedirman University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Nuniek Ina RatnaningtyasAfiliasi tidak diketahui2
Hendri WasitoAfiliasi tidak diketahui2
Sismindari SismindariAfiliasi tidak diketahui1
Ratna Asmah SusidartiAfiliasi tidak diketahui1
Oedjijono OedjijonoAfiliasi tidak diketahui1
Nanik RahmaniAfiliasi tidak diketahui1
Rina Dwi AgustianiAfiliasi tidak diketahui1
Witiyasti ImaningsihAfiliasi tidak diketahui1
Loekas SoesantoAfiliasi tidak diketahui1
Salamiah .Afiliasi tidak diketahui1
HERNAYANTI HERNAYANTIAfiliasi tidak diketahui1
Bambang Heru BudiantoAfiliasi tidak diketahui1
Fajar HusenAfiliasi tidak diketahui1
Hartiwi DiastutiJenderal Soedirman University1
Eka Prasasti Nur RachmaniAfiliasi tidak diketahui1
Sarmoko SarmokoAfiliasi tidak diketahui1
Tuti Sri SuhestiAfiliasi tidak diketahui1
Muhamad Salman FarezaAfiliasi tidak diketahui1
Nur Amalia ChoironiAfiliasi tidak diketahui1
Rehana RehanaAfiliasi tidak diketahui1
Genta Hafied Naga SamudraAfiliasi tidak diketahui1
Syahdan AsradaAfiliasi tidak diketahui1
Dafi FischellyaAfiliasi tidak diketahui1
Ika MustikaningtyasAfiliasi tidak diketahui1
Lulu SetiyabudiAfiliasi tidak diketahui1
HENY EKOWATIAfiliasi tidak diketahui1
Geeta MaryellenAfiliasi tidak diketahui1
Tasya Melinda SilitongaAfiliasi tidak diketahui1
Firdaus OktavianAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Antibacterial Activity of Acanthus ilicifolius L. n-Hexane Fraction</dc:title>
	<dc:creator>warsinah, warsinah</dc:creator>
	<dc:creator>Wijaya, Triyadi Hendra</dc:creator>
	<dc:creator>Ekowati, Nuraeni</dc:creator>
	<dc:description xml:lang="en-US">Background: Recently, with the high prevalence of diarrhoea caused by bacterial infection, the usage of antibiotics has increased. Antibiotic overuse might lead to several side effects and resistance, suggesting the development of an alternate antibacterial agent. A mangrove plant, Acanthus Illinois, contained triterpenoid, which has antibacterial properties.
Aim: This study aimed to evaluate the antibacterial effect of the Acanthus Illinois n-hexane fraction against Escherichia coli and Shigella dysenteriae.
Method: The Acanthus Illinois was fraction using n-Hexane, identification of secondary metabolite compound using GC-MS, and evaluation of antibacterial activity against Escherichia coli and Shigella dysenteriae under paper disc methods. This study was designed using a fully randomized design (CRD) with concentrations of fractions 1%, 2%, and 4%. The GC-MS results were compared to the WILEY 9 library and analysed. A prism graph was used to measure the inhibition zone of antibacterial activity.
Result: The n-hexane fraction yield is 3.3% and contains sesquiterpene compounds (trans (beta.)-caryophyllene, alpha humulene, naphthalene decahedron-4A-methyl), terpenoid alcohol (3,7,11,15-tetramethyl -2-hexadecane-1-ol), and fatty acids (hexadecanoic acid methyl ester. Acanthus Illinois n-hexane fraction has antibacterial activity against Escherichia coli and Shigella dysenteriae in&amp;nbsp;a dose-dependent manner. &amp;nbsp;
Conclusion: The n-hexane fraction of leaves Acanthus ilicifolius contains sesquiterpene, alcohol terpenoids, and fatty, and has antibacterial activity against Escherichia coli and Shigella dysenteriae&amp;nbsp; 
&amp;nbsp;</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2022-01-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/JSTRP/article/view/49615</dc:identifier>
	<dc:identifier>10.15294/jstrp.v1i2.49615</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Science and Technology Research for Pharmacy; Vol 1 No 2 (2021); 48-56</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:source>10.15294/jstrp.v1i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/JSTRP/article/view/49615/20887</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>