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Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis

Journal of Science and Technology Research for Pharmacy · Vol. 1 No. 2 (2022) · hlm. 72–77

DOI
10.15294/jstrp.v1i2.51512
ISSN
2776-0685
Terbit
2022-02-02
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Background: Cancer is a disease caused by abnormal growth of body tissue cells. Cancer treatment strategy by induce apoptosis and inhibit proliferation. Aim: This research aims to examine the anticancer effect of Alpinia galanga extract on MCF-7/HER2+ breast cancer cells. Method: The MTT Assay cytotoxic test was carried out to determine the growth inhibitory activity. Apoptotic assay to determine the activity of compounds in apoptosis, as well as through a structural approach utilizing various virtual platforms to monitor its activity. Result: Based on the MTT assay Alpinia galanga extract possessed cytotoxic effect in dose-dependent manner with IC50 value of 330.79 μg/mL. The extract induces apoptosis of MCF-7 cells up to 25.56%. Conclusion: It can be concluded that Alpinia galanga extract demonstrated cytotoxic activity toward MCF-7/HER2+ breast through apoptosis induction. This extract had an opportunity to be developed as a potential anticancer agent to overcome breast cancer diseases.

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  • University of Brawijaya
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Agung PutraAfiliasi tidak diketahui2
Nur Dina AmalinaAfiliasi tidak diketahui1
Sri Priyantini MulyaniAfiliasi tidak diketahui1
Alisia Martha DewiAfiliasi tidak diketahui1
Setyo TrisnasiAfiliasi tidak diketahui1
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Eko SetiawanUniversity of Brawijaya1
Titiek SumarawatiAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/JSTRP/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis</dc:title>
	<dc:creator>Ibrahim, Sugeng</dc:creator>
	<dc:description xml:lang="en-US">Background: Cancer is a disease caused by abnormal growth of body tissue cells. Cancer treatment strategy by induce apoptosis and inhibit proliferation.
Aim: This research aims to examine the anticancer effect of Alpinia galanga extract on MCF-7/HER2+ breast cancer cells.&amp;nbsp;
Method: The MTT Assay cytotoxic test was carried out to determine the growth inhibitory activity. Apoptotic assay to determine the activity of compounds in apoptosis, as well as through a structural approach utilizing various virtual platforms to monitor its activity.
Result: Based on the MTT assay Alpinia galanga extract possessed cytotoxic effect in dose-dependent manner with IC50 value of 330.79 μg/mL. The extract induces apoptosis of MCF-7 cells up to 25.56%.
Conclusion: It can be concluded that Alpinia galanga extract demonstrated cytotoxic activity toward MCF-7/HER2+ breast through apoptosis induction. This extract had an opportunity to be developed as a potential anticancer agent to overcome breast cancer diseases.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2022-02-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/JSTRP/article/view/51512</dc:identifier>
	<dc:identifier>10.15294/jstrp.v1i2.51512</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Science and Technology Research for Pharmacy; Vol 1 No 2 (2021); 72-77</dc:source>
	<dc:source>2776-0685</dc:source>
	<dc:source>10.15294/jstrp.v1i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/JSTRP/article/view/51512/21238</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Journal of Science and Technology Research for Pharmacy</dc:rights>
</oai_dc:dc>