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The Effect of Tamarind Fruit Nanoparticles (Tamarindus indica) on the Sperm Quality of Hyperglycemic Rats

Life Science · Vol. 14 No. 2 (2025) · hlm. 69–77

DOI
10.15294/unnesjlifesci.v14.i2.24064
ISSN
2528-5009, 2252-6277
Terbit
2025-11-30
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Hyperglycemia is an increase in glucose levels in the blood. This condition can trigger glucose autooxidation which can produce free radicals. Free radicals can cause damage to male reproductive organs and quality. Tamarind fruit has a high flavonoid which has the potential as an antioxidant. This study aims to analyze the effect of tamarind fruit nanoparticles on spermatozoa quality in hyperglycemic rats. This study is experimental with Post-Test Control Group Design. A sample of 15 male Wistar rats were induced by alloxan and then divided into three groups, namely the control group, tamarind fruit nanoparticles with a dose of 30 mg/KgBB (NP1) and 60 mg/KgBB (NP2) for 28 days. Sperm quality was observed with parameters of concentration, motility and viability. The data were analyzed using One Way ANOVA and LSD. The results of the Anova test showed that tamarind nanoparticle treatment could significantly improve sperm quality (P<0.05). The LSD test showed that the concentration, motility and viability of sperm in group (K) were significantly different from groups NP1 and NP2. The highest to lowest average sperm concentration in sequence was in groups NP2 (49.60x106±6.06x106), NP1 (41.60x106±7.40x106) and K (20.80x106±7.56x106). The highest to lowest average percentage of sperm motility in sequence was in groups NP2 (82.20±9.75), NP1 (74.00±4.74), K (47.20±10.66). The highest to lowest average percentage of sperm viability in sequence was in the NP2 group (76.80±4.49), NP1 (72.20±7.12), K (31.60±7.89). The conclusion of this study is that tamarind nanoparticles have an effect on improving sperm quality in hyperglycemic rats.

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  • State University of Semarang
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Ari YuniastutiState University of Semarang11
Aditya MariantiAfiliasi tidak diketahui9
Lisdiana LisdianaAfiliasi tidak diketahui8
Retno Sri IswariState University of Semarang6
LisdianaAfiliasi tidak diketahui6
Siti Harnina BintariAfiliasi tidak diketahui3
Wiwi IsnaeniState University of Semarang3
Priyantini WidiyaningrumAfiliasi tidak diketahui3
Didik Huswo UtomoAfiliasi tidak diketahui3
Ani RusilowatiState University of Semarang2
Enni Suwarsi RahayuState University of Semarang2
Lili Astuti IsnaeniAfiliasi tidak diketahui2
Kartika WidiyaningrumAfiliasi tidak diketahui2
Endah PeniatiState University of Semarang2
Pramesti DewiAfiliasi tidak diketahui2
Dyah Rini IndriyantiState University of Semarang2
Yanuarita TursinawatiAfiliasi tidak diketahui1
Prima Gita IslamiAfiliasi tidak diketahui1
Dinar Diyah AstutiAfiliasi tidak diketahui1
Prima Gita Islami IslamiAfiliasi tidak diketahui1
Eva Ulfiatus ShofiaAfiliasi tidak diketahui1
Revinta Nur Aulia RochlyAfiliasi tidak diketahui1
Anggun Try SetyaningsihAfiliasi tidak diketahui1
Nana Kariada MartutiAfiliasi tidak diketahui1
Retno PurwantiAfiliasi tidak diketahui1
- UmarudinAfiliasi tidak diketahui1
Arif HidayatAfiliasi tidak diketahui1
Rheza Alfy YuliantoAfiliasi tidak diketahui1
Yuliana AstrianaAfiliasi tidak diketahui1
SITI QOMARIAHAfiliasi tidak diketahui1
Ning SetiatiAfiliasi tidak diketahui1
Muhammad Rofiq NezarAfiliasi tidak diketahui1
Margareta RahayuningsihAfiliasi tidak diketahui1
Denny Herbianto BahtiarAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/UnnesJLifeSci/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Effect of Tamarind Fruit Nanoparticles (Tamarindus indica) on the Sperm Quality of Hyperglycemic Rats</dc:title>
	<dc:creator xml:lang="en">Bagus Hammam Falah</dc:creator>
	<dc:creator xml:lang="en">Wulan Christijanti</dc:creator>
	<dc:creator xml:lang="en">Nugrahaningsih WH</dc:creator>
	<dc:creator xml:lang="en">R. Susanti</dc:creator>
	<dc:subject xml:lang="en">Hyperglicemia</dc:subject>
	<dc:subject xml:lang="en">Nanoparticles</dc:subject>
	<dc:subject xml:lang="en">Tamarind Fruit</dc:subject>
	<dc:subject xml:lang="en">Sperm Quality</dc:subject>
	<dc:description xml:lang="en">Hyperglycemia is an increase in glucose levels in the blood. This condition can trigger glucose autooxidation which can produce free radicals. Free radicals can cause damage to male reproductive organs and quality. Tamarind fruit has a high flavonoid which has the potential as an antioxidant. This study aims to analyze the effect of tamarind fruit nanoparticles on spermatozoa quality in hyperglycemic rats. This study is experimental with Post-Test Control Group Design. A sample of 15 male Wistar rats were induced by alloxan and then divided into three groups, namely the control group, tamarind fruit nanoparticles with a dose of 30 mg/KgBB (NP1) and 60 mg/KgBB (NP2) for 28 days. Sperm quality was observed with parameters of concentration, motility and viability. The data were analyzed using One Way ANOVA and LSD. The results of the Anova test showed that tamarind nanoparticle treatment could significantly improve sperm quality (P&amp;lt;0.05). The LSD test showed that the concentration, motility and viability of sperm in group (K) were significantly different from groups NP1 and NP2. The highest to lowest average sperm concentration in sequence was in groups NP2 (49.60x106±6.06x106), NP1 (41.60x106±7.40x106) and K (20.80x106±7.56x106). The highest to lowest average percentage of sperm motility in sequence was in groups NP2 (82.20±9.75), NP1 (74.00±4.74), K (47.20±10.66). The highest to lowest average percentage of sperm viability in sequence was in the NP2 group (76.80±4.49), NP1 (72.20±7.12), K (31.60±7.89). The conclusion of this study is that tamarind nanoparticles have an effect on improving sperm quality in hyperglycemic rats.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/UnnesJLifeSci/article/view/24064</dc:identifier>
	<dc:identifier>10.15294/unnesjlifesci.v14.i2.24064</dc:identifier>
	<dc:source xml:lang="en">Life Science; Vol. 14 No. 2 (2025): November 2025; 69-77</dc:source>
	<dc:source>2528-5009</dc:source>
	<dc:source>2252-6277</dc:source>
	<dc:source>10.15294/unnesjlifesci.v14.i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/UnnesJLifeSci/article/view/24064/7280</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Life Science</dc:rights>
</oai_dc:dc>