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Non-Ribosomal Inhibition of The Antibacterial Compound from Ethanol Extract of Gnetii gnemon

Life Science · Vol. 12 No. 2 (2023) · hlm. 174–185

DOI
10.15294/lifesci.v12i2.67183
ISSN
2528-5009, 2252-6277
Terbit
2023-11-28
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Melinjo (Gnetii gnemonii Folium) is a plant species originating from Peninsular Malaysia and Indonesia, known that contain several bioactive compounds that can be utilized as antibacterial agent. The aims of this study to analyze the profile of the melinjo leaf (Gnetii gnemonii Folium) bioactive compound which has an antimicrobial function by inhibiting the growth of S. aureus and activity in Ribosomal expression. The profile analysis of bioactive compound of melinjo leaf was carried out by screening phytochemical study, HPLC and analysis of antibacterial activity was carried out using turbidimetry method against Bacillus cereus (Bc), Escherichia coli (Ec), and Staphylococcus aureus (Sa). The ethanol extract of melinjo leaves contains tannins, saponins, alkaloids, flavonoids, triterpenoids, with the highest levels being flavonoids 67,117ppm. Analysis of bacterial growth using OD600 showed relatively lower antibacterial activity compared to control. The identification of RNA expression showed that the antibacterial compound of melinjo leaf extract did not have inhibition activity through the ribosome pathway it was thought to have an antibacterial mechanism through non-ribosomal inhibition of bacteria.

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  • Universitas Jambi
  • Sekolah Tinggi Agama Buddha Negeri Raden Wijaya Wonogiri
  • Universitas Muslim Indonesia
  • Universitas Islam Negeri Antasari Banjarmasin
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Rekan penulisOrganisasiArtikel bersama
Yusnaidar YusnaidarUniversitas Jambi10
Sutrisno SutrisnoSekolah Tinggi Agama Buddha Negeri Raden Wijaya Wonogiri4
Elis KartikaAfiliasi tidak diketahui4
Alfi KhatibAfiliasi tidak diketahui4
Samsidar SamsidarUniversitas Muslim Indonesia3
NelsonAfiliasi tidak diketahui3
Muhaimin MuhaiminUniversitas Islam Negeri Antasari Banjarmasin2
Uce LestariAfiliasi tidak diketahui2
Kartika Arum WardaniAfiliasi tidak diketahui2
Novintan ElystiaAfiliasi tidak diketahui2
Lizawati LizawatiAfiliasi tidak diketahui2
Muhammad Irhash ShalihinAfiliasi tidak diketahui2
Adzuan Handi DuansyahAfiliasi tidak diketahui2
Nurul HudaAfiliasi tidak diketahui2
Silvi Leila RahmiAfiliasi tidak diketahui2
addion nizoriAfiliasi tidak diketahui2
Annisa Candra NabilaAfiliasi tidak diketahui2
Yus Aniza YusofAfiliasi tidak diketahui2
Heriyanti HeriyantiAfiliasi tidak diketahui2
Diah Riski GustiAfiliasi tidak diketahui1
Intan LestariAfiliasi tidak diketahui1
Aditya Denny PrabawaAfiliasi tidak diketahui1
Edwin PermanaAfiliasi tidak diketahui1
Nelson NelsonAfiliasi tidak diketahui1
Ngatijo NgatijoAfiliasi tidak diketahui1
Hamdan Maruli SiregarAfiliasi tidak diketahui1
Tri SiswantoAfiliasi tidak diketahui1
Muhammad FikramAfiliasi tidak diketahui1
Suci LestariAfiliasi tidak diketahui1
Linda WahyuniAfiliasi tidak diketahui1
Misbahul KhasanahAfiliasi tidak diketahui1
Rasyifa SuciAfiliasi tidak diketahui1
Halimah Tusa’diahAfiliasi tidak diketahui1
Muhamad IkhwalAfiliasi tidak diketahui1
Ardiyanto SaputraAfiliasi tidak diketahui1
Adi PrayogaAfiliasi tidak diketahui1
Jamilah JamilahAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/UnnesJLifeSci/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Non-Ribosomal Inhibition of The Antibacterial Compound from Ethanol Extract of Gnetii gnemon</dc:title>
	<dc:creator>Tarigan, Indra Lasmana</dc:creator>
	<dc:creator>Muadifah, Afidatul</dc:creator>
	<dc:creator>Latief, Madyawati</dc:creator>
	<dc:description xml:lang="en-US">Melinjo (Gnetii gnemonii Folium) is a plant species originating from Peninsular Malaysia and Indonesia, known that contain several bioactive compounds that can be utilized as antibacterial agent. The aims of this study to analyze the profile of the melinjo leaf (Gnetii gnemonii Folium) bioactive compound which has an antimicrobial function by inhibiting the growth of S. aureus and activity in Ribosomal expression. The profile analysis of bioactive compound of melinjo leaf was carried out by screening phytochemical study, HPLC and analysis of antibacterial activity was carried out using turbidimetry method against Bacillus cereus (Bc), Escherichia coli (Ec), and Staphylococcus aureus (Sa). The ethanol extract of melinjo leaves contains tannins, saponins, alkaloids, flavonoids, triterpenoids, with the highest levels being flavonoids 67,117ppm. Analysis of bacterial growth using OD600 showed relatively lower antibacterial activity compared to control. The identification of RNA expression showed that the antibacterial compound of melinjo leaf extract did not have inhibition activity through the ribosome pathway it was thought to have an antibacterial mechanism through non-ribosomal inhibition of bacteria.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2023-11-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/UnnesJLifeSci/article/view/67183</dc:identifier>
	<dc:identifier>10.15294/lifesci.v12i2.67183</dc:identifier>
	<dc:source xml:lang="en-US">Life Science; Vol 12 No 2 (2023): November 2023; 174-185</dc:source>
	<dc:source>2528-5009</dc:source>
	<dc:source>2252-6277</dc:source>
	<dc:source>10.15294/lifesci.v12i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/UnnesJLifeSci/article/view/67183/25833</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Life Science</dc:rights>
</oai_dc:dc>