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Topical Ointment Anredera cordifolia Leaves Ethanolic Extract-Loaded Nanochitosan Promotes Wound Healing in Hyperglycemic Rat

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 1 (2024) · hlm. 155–165

DOI
10.15294/biosaintifika.v15i1.1842
ISSN
2338-7610, 2085-191X
Terbit
2024-04-20
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Wound healing in hyperglycemia patients is still a challenge in the medical field. Bioactive compounds of binahong leaf extract can support the wound healing process. Nanoencapsulation of the extract can avoid oxidation and optimize drug delivery to target tissues. This study aimed to analyze the effect of nanochitosan encapsulated binahong extract ointment (NEBE/Oint) on the percentage of wound healing, angiogenesis, collagen density, and epithelial thickness in hyperglycemic rats. This study used 80 mg/kg streptozotocin-induced hyperglycemia rats injured in the back area. Rats were divided into P0 (0,9% NaCl), P1 (10% povidone-iodine ointment (PI/Oint)), P2 (10% NEBE/Oint), P3 (20% NEBE/Oint), P4 (30% NEBE/Oint). Phytochemical screening of binahong leaves extract showed positive results for flavonoids, alkaloids, saponins, and tannins. NEBE particle size was 169 nm with a size distribution of 0.2 and a zeta potential value of -40,2 mV. The results showed NEBE ointment had a significant effect when compared with negative control on wound healing hyperglycemic rats. The conclusion is that nanochitosan drug delivery has the potential as an alternative wound treatment. The novelty of this study is the use of nanochitosan to accelerate wound healing in hyperglycemic rats. The results of this study are expected to become a reference for new wound-healing methods in the medical field.

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  • State University of Semarang
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Kustopo BudiraharjoAfiliasi tidak diketahui5
Dwinanda BudiwardaniAfiliasi tidak diketahui3
Cinta Etna SyakeraAfiliasi tidak diketahui2
Laode ErmanjayaAfiliasi tidak diketahui2
Maisya Sifana MauraAfiliasi tidak diketahui2
Muhammad Anwar DjaelaniAfiliasi tidak diketahui2
Langlang HandayaniAfiliasi tidak diketahui1
Teguh DarsonoAfiliasi tidak diketahui1
Slamet HaryonoAfiliasi tidak diketahui1
Usrek Tani UtinaAfiliasi tidak diketahui1
Haydnn Caesha MaulanaAfiliasi tidak diketahui1
Musa Abdul HalimAfiliasi tidak diketahui1
Iklas Adi PangestuAfiliasi tidak diketahui1
Nabila Rakha PutriAfiliasi tidak diketahui1
Masturi MasturiState University of Semarang1
Yohannes SardjonoAfiliasi tidak diketahui1
Rio Agustian Gilang FernandoAfiliasi tidak diketahui1
Pratiwi DwijanantiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Topical Ointment Anredera cordifolia Leaves Ethanolic Extract-Loaded Nanochitosan Promotes Wound Healing in Hyperglycemic Rat</dc:title>
	<dc:creator xml:lang="en">Alfatinnisa, Zalfa </dc:creator>
	<dc:creator xml:lang="en">Andriyan, Mohammad Wahyu </dc:creator>
	<dc:creator xml:lang="en">Saputra, Muhammad Ragil </dc:creator>
	<dc:creator xml:lang="en">Astuti, Endah Puji </dc:creator>
	<dc:creator xml:lang="en">Sunarno, Sunarno</dc:creator>
	<dc:creator xml:lang="en">Isdadiyanto, Sri </dc:creator>
	<dc:creator xml:lang="en">Subagio, Agus </dc:creator>
	<dc:creator xml:lang="en">Jaya, La Ode Irman </dc:creator>
	<dc:subject xml:lang="en">binahong (Anredera cordifolia), hyperglycemia, nanoencapsulation, wound healing</dc:subject>
	<dc:description xml:lang="en">Wound healing in hyperglycemia patients is still a challenge in the medical field. Bioactive compounds of binahong leaf extract can support the wound healing process. Nanoencapsulation of the extract can avoid oxidation and optimize drug delivery to target tissues. This study aimed to analyze the effect of nanochitosan encapsulated binahong extract ointment (NEBE/Oint) on the percentage of wound healing, angiogenesis, collagen density, and epithelial thickness in hyperglycemic rats. This study used 80 mg/kg streptozotocin-induced hyperglycemia rats injured in the back area. Rats were divided into P0 (0,9% NaCl), P1 (10% povidone-iodine ointment (PI/Oint)), P2 (10% NEBE/Oint), P3 (20% NEBE/Oint), P4 (30% NEBE/Oint). Phytochemical screening of binahong leaves extract showed positive results for flavonoids, alkaloids, saponins, and tannins. NEBE particle size was 169 nm with a size distribution of 0.2 and a zeta potential value of -40,2 mV. The results showed NEBE ointment had a significant effect when compared with negative control on wound healing hyperglycemic rats. The conclusion is that nanochitosan drug delivery has the potential as an alternative wound treatment. The novelty of this study is the use of nanochitosan to accelerate wound healing in hyperglycemic rats. The results of this study are expected to become a reference for new wound-healing methods in the medical field.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-04-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/1842</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v15i1.1842</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 1 (2024): April 2024; 155-165</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/1842/177</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>