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The Role of Sembung (Blumea balsamifera) Leaf Extract in Preventing Atherosclerosis in Hyperlipidemia Rat Models

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 2 (2024) · hlm. 254–264

DOI
10.15294/biosaintifika.v16i2.6673
ISSN
2338-7610, 2085-191X
Terbit
2024-08-15
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

This study aims to prove that administering BBLE as a natural antioxidant can prevent atherosclerosis by maintaining lipid profiles, antioxidant enzymes, and netrin-1 levels in hyperlipidemia in rat models. The research subjects were 20 adult male Wistar rats (Rattus norvegicus), which were divided into 2 groups using a randomized pretest and posttest control group design. Before treatment and after treatment for 3 months, lipid profiles, MDA, SOD, and netrin-1 were examined. The control group was only given high-cholesterol diets (HCD), while the treatment, apart from HCD, was also given BBLE 4mg/day. The data obtained was tested using paired t-test and group t-test. The results of the study showed that there was a significant decrease in netrin-1 in the control group (p 0.05). Netrin-1 levels in the treatment group were higher than the control (p<0.05). The lipid profile experienced a significant increase in HDL in the treatment group accompanied by a significant decrease in MDA and an increase in SOD (p<0.05) when compared with the control group. This study concludes that administering BBLE at a dose of 4 mg/day to rats given HCD caused an increase in netrin-1 levels accompanied by improvements in lipid profiles and prevention of oxidative stress. The findings of this study reveal the novelty of BBLE in treating and maintaining blood vessel function in mice given HCD by increasing netrin-1 levels.

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  • Udayana University
  • Universitas Dhyana Pura
  • Universitas Airlangga
  • Universitas Negeri Surabaya
  • Ministry of Marine Affairs and Fisheries
  • Myitkyina University
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
I Made Gde Sudyadnyana SandhikaUniversitas Dhyana Pura8
I Wayan RosianaUniversitas Dhyana Pura8
Anak Agung Ayu Putri PermatasariUniversitas Dhyana Pura7
Putu Eka SudaryatmaMinistry of Marine Affairs and Fisheries6
Bambang YuliantoDiponegoro University4
Agoes SoegiantoUniversitas Airlangga4
Yesha Ainesis El Gracianita PelupessyUniversitas Dhyana Pura4
I Gede WidhiantaraAfiliasi tidak diketahui4
Putu Angga WiradanaAfiliasi tidak diketahui4
I Made Gde Sudyadnyana SandhikaAfiliasi tidak diketahui4
I Wayan RosianaAfiliasi tidak diketahui4
Ni Kadek Yunita SariAfiliasi tidak diketahui4
Ni Kadek Yunita SariUniversitas Dhyana Pura4
Aris JatmikoMinistry of Marine Affairs and Fisheries3
Teguh Hari SuciptoUniversitas Airlangga3
SutirtaYasa, I W. PAfiliasi tidak diketahui1
Anak Agung Bawa PutraUdayana University1
Ida Bagus Putra ManuabaUdayana University1
I Made SiakaUdayana University1
I Made BaktaUdayana University1
Karna WijayaUniversitas Gadjah Mada1
Parwata Oka Adi ParwataUdayana University1
I Made SukadanaUdayana University1
I Wayan SusilaUdayana University1
Aunu RaufIPB University1
I Wayan SuparthaUdayana University1
B. Merle ShepardClemson University1
I Wayan Eka Karya UtamaUdayana University1
I Wayan SandikayasaUdayana University1
I Kadek Wisma YudhaUdayana University1
Shifa FauziyahUniversitas Airlangga1
Mirwa Adiprahara AnggaraniUniversitas Negeri Surabaya1
Dzikra Nasyaya MahfudhahUniversitas Negeri Surabaya1
Fistara Lesti RahmafitriaUniversitas Negeri Surabaya1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Role of Sembung (Blumea balsamifera) Leaf Extract in Preventing Atherosclerosis in Hyperlipidemia Rat Models</dc:title>
	<dc:creator xml:lang="en">I Made Jawi</dc:creator>
	<dc:creator xml:lang="en">I Wayan Putu Sutirta Yasa</dc:creator>
	<dc:creator xml:lang="en">I Gede Widhiantara</dc:creator>
	<dc:creator xml:lang="en">Anak Agung Ngurah Subawa</dc:creator>
	<dc:creator xml:lang="en">Putu Angga Wiradana </dc:creator>
	<dc:creator xml:lang="en">Naw, Sin War </dc:creator>
	<dc:subject xml:lang="en">Blumea balsamifera</dc:subject>
	<dc:subject xml:lang="en">Herbal medicines</dc:subject>
	<dc:subject xml:lang="en">Herbal products</dc:subject>
	<dc:subject xml:lang="en">Dyslipidemia</dc:subject>
	<dc:subject xml:lang="en">Oxidative stress</dc:subject>
	<dc:description xml:lang="en">This study aims to prove that administering BBLE as a natural antioxidant can prevent atherosclerosis by maintaining lipid profiles, antioxidant enzymes, and netrin-1 levels in hyperlipidemia in rat models. The research subjects were 20 adult male Wistar rats (Rattus norvegicus), which were divided into 2 groups using a randomized pretest and posttest control group design. Before treatment and after treatment for 3 months, lipid profiles, MDA, SOD, and netrin-1  were examined. The control group was only given high-cholesterol diets (HCD), while the treatment, apart from HCD, was also given BBLE 4mg/day. The data obtained was tested using paired t-test and group t-test. The results of the study showed that there was a significant decrease in netrin-1 in the control group (p&amp;lt;0.05) after being given HCD for three months. In the treatment group, it also decreased but it was not significant (p&amp;gt;0.05). Netrin-1 levels in the treatment group were higher than the control (p&amp;lt;0.05). The lipid profile experienced a significant increase in HDL in the treatment group accompanied by a significant decrease in MDA and an increase in SOD (p&amp;lt;0.05) when compared with the control group. This study concludes that administering BBLE at a dose of 4 mg/day to rats given HCD caused an increase in netrin-1 levels accompanied by improvements in lipid profiles and prevention of oxidative stress. The findings of this study reveal the novelty of BBLE in treating and maintaining blood vessel function in mice given HCD by increasing netrin-1 levels.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-08-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/6673</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v16i2.6673</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 2 (2024): August 2024; 254-264</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/6673/1158</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>