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Antihyperlipidemic Activity of Tamarind (Tamarindus indica) Extract on the Lipid Profile of Albino Rats

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 1 (2024) · hlm. 191–197

DOI
10.15294/biosaintifika.v15i1.7579
ISSN
2338-7610, 2085-191X
Terbit
2024-04-20
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Tamarind are widely used as antioxidants, anti-diabetes, anti-hyperlipidemia, and anti-cholesterolemia. The aim of this research is to analyze the anti-hyperlipidemic activity of extracts of tamarind fruit pulp, seeds and leaves on the lipid profile of rats. Experimental research was designed with 20 male rats divided Control (C), Tamarind leaves (TL), Tamarind fruit pulp (TF), and Tamarind seeds (TS) extracts, each 500 mg/kg of body weight. All of the groups were given standard feed and induced with lard at 3 ml/rat/day for 14 days. On day 15, the rats were continued to be induced with lard and were given extracts according to each group for 2 weeks. The data obtained such as rats’ body weight, level of cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglycerides (TG) and Malondialdehyde (MDA) were analyzed using anova (P<0.05) and the Duncan Multiple Range Test (DMRT). The results showed that each extract had a significant effect on cholesterol, HDL and MDA levels but not on body weight, LDL and triglycerides. Levels of MDA in the group with the extract were significantly lower than the control. Tamarind pulp, seeds and leaf extracts show antihyperlipidemic activity by reducing cholesterol and HDL levels. This can be the basis for using parts of the tamarind plant as a supplement for the community to maintain fat levels.

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Ari YuniastutiState University of Semarang8
Aditya MariantiAfiliasi tidak diketahui8
Retno Sri IswariState University of Semarang5
Lisdiana LisdianaAfiliasi tidak diketahui4
Siti Harnina BintariAfiliasi tidak diketahui3
LisdianaAfiliasi tidak diketahui3
Nugrahaningsih WHAfiliasi tidak diketahui3
Wiwi IsnaeniState University of Semarang3
Priyantini WidiyaningrumAfiliasi tidak diketahui2
Ani RusilowatiState University of Semarang2
Didik Huswo UtomoAfiliasi tidak diketahui2
Enni Suwarsi RahayuState University of Semarang2
Lili Astuti IsnaeniAfiliasi tidak diketahui2
Kartika WidiyaningrumAfiliasi tidak diketahui2
Bagus Hammam FalahAfiliasi tidak diketahui2
Pramesti DewiAfiliasi tidak diketahui2
Yanuarita TursinawatiAfiliasi tidak diketahui1
Prima Gita IslamiAfiliasi tidak diketahui1
Dinar Diyah AstutiAfiliasi tidak diketahui1
Prima Gita Islami IslamiAfiliasi tidak diketahui1
K Syifa FauziyahAfiliasi tidak diketahui1
Tristania Magdalena DumatubunAfiliasi tidak diketahui1
Thianika Shalsabillah ArmandokoAfiliasi tidak diketahui1
Eva Ulfiatus ShofiaAfiliasi tidak diketahui1
Nabila Meilani DewiAfiliasi tidak diketahui1
Arneta EvaniaAfiliasi tidak diketahui1
Anggun Try SetyaningsihAfiliasi tidak diketahui1
Nana Kariada MartutiAfiliasi tidak diketahui1
Retno PurwantiAfiliasi tidak diketahui1
- UmarudinAfiliasi tidak diketahui1
Arif HidayatAfiliasi tidak diketahui1
Rheza Alfy YuliantoAfiliasi tidak diketahui1
Yuliana AstrianaAfiliasi tidak diketahui1
SITI QOMARIAHAfiliasi tidak diketahui1
Muhammad Rofiq NezarAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Antihyperlipidemic Activity of Tamarind (Tamarindus indica) Extract on the Lipid Profile of Albino Rats</dc:title>
	<dc:creator xml:lang="en">Christijanti, Wulan </dc:creator>
	<dc:creator xml:lang="en">Susanti, R. </dc:creator>
	<dc:creator xml:lang="en">Rakainsa, Senda Kartika </dc:creator>
	<dc:creator xml:lang="en">Widyaningrum, Kartika </dc:creator>
	<dc:creator xml:lang="en">Mohamed, Mohd Salim Bin </dc:creator>
	<dc:subject xml:lang="en">anti-hyperlipidemia; lipid profile; malondialdehyde; tamarind</dc:subject>
	<dc:description xml:lang="en">Tamarind are widely used as antioxidants, anti-diabetes, anti-hyperlipidemia, and anti-cholesterolemia. The aim of this research is to analyze the anti-hyperlipidemic activity of extracts of tamarind fruit pulp, seeds and leaves on the lipid profile of rats.
Experimental research was designed with 20 male rats divided   Control (C), Tamarind leaves (TL), Tamarind fruit pulp (TF), and Tamarind seeds (TS) extracts, each 500 mg/kg of body weight. All of the groups were given standard feed and induced with lard at 3 ml/rat/day for 14 days. On day 15, the rats were continued to be induced with lard and were given extracts according to each group for 2 weeks. The data obtained such as rats’ body weight, level of cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglycerides (TG) and Malondialdehyde (MDA)  were analyzed using anova (P&amp;lt;0.05) and the Duncan Multiple Range Test (DMRT). The results showed that each extract had a significant effect on cholesterol, HDL and MDA levels but not on body weight, LDL and triglycerides. Levels of MDA in the group with the extract were significantly lower than the control. Tamarind pulp, seeds and leaf extracts show antihyperlipidemic activity by reducing cholesterol and HDL levels.
This can be the basis for using parts of the tamarind plant as a supplement for the community to maintain fat levels.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-04-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/7579</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v15i1.7579</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 1 (2024): April 2024; 191-197</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/7579/850</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>