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A Cytotoxic Activity of Clitoria ternatea Flower Tea with the Cinnamon and Lemongrass Oil Vapor against T47D Breast Cancer Cells

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 3 (2024) · hlm. 525–534

DOI
10.15294/biosaintifika.v16i3.8480
ISSN
2338-7610, 2085-191X
Terbit
2024-12-24
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Breast cancer is a deadly disease for women. It is crucial to take preventive measures, one of which involves using natural ingredients as chemopreventive agents. Clitoria ternatea flowers, cinnamon, and lemongrass oil have been proven to have cytotoxic activity in several studies. This research aims to analyze the effect of adding cinnamon and lemongrass oil vapor to C. ternatea flower tea on the cytotoxic activity of T47D breast cancer cells. Cytotoxic activity testing was carried out colorimetrically using the MTT (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay method. The results of the research showed that there was a decrease in the IC50 value of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor. The IC50 value of C. ternatea flower tea without additional ingredients was the most potent with 14159 μg/mL, compared to 15 g addition of cinnamon with 1164 μg/mL; meanwhile, for 15 seconds of evaporation time for lemongrass, it was at 331 μg/mL, respectively This research shows the potential of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor as a chemopreventive agent against breast cancer cells.

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  • State University of Semarang
  • Universitas Sains Al-Qur'an
  • Universiti Sains Islam Malaysia
  • Walisongo State Islamic University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Eko Budi SusatyoAfiliasi tidak diketahui4
Kusoro SiadiAfiliasi tidak diketahui4
Supartono SupartonoAfiliasi tidak diketahui4
Nanik WijayatiState University of Semarang4
Ari YuniastutiState University of Semarang3
Lisdiana LisdianaAfiliasi tidak diketahui3
Sudarmin SudarminAfiliasi tidak diketahui3
Sri MursitiAfiliasi tidak diketahui3
Harjono HarjonoAfiliasi tidak diketahui3
LisdianaAfiliasi tidak diketahui2
R. SusantiAfiliasi tidak diketahui2
Ersanghono KusumoAfiliasi tidak diketahui2
Bowo NurcahyoAfiliasi tidak diketahui2
Endang SusilaningsihState University of Semarang2
Sri JuminiUniversitas Sains Al-Qur'an1
Sutikno MadnasriState University of Semarang1
Yatim Md NadrahUniversiti Sains Islam Malaysia1
H HamzahAfiliasi tidak diketahui1
F FatiatunUniversitas Sains Al-Qur'an1
L. LastriState University of Semarang1
Apriliana DrastisiantiWalisongo State Islamic University1
E. KusumoState University of Semarang1
Trevor Graham OngomAfiliasi tidak diketahui1
Etik Siswati NingrumAfiliasi tidak diketahui1
Ratzinger LodoAfiliasi tidak diketahui1
Aleda MaweneAfiliasi tidak diketahui1
. RidwanAfiliasi tidak diketahui1
Indira RiastiwiAfiliasi tidak diketahui1
WitjaksonoAfiliasi tidak diketahui1
Sri Malahayati YusufAfiliasi tidak diketahui1
Gilang MunggaranAfiliasi tidak diketahui1
Kartika TriasaryAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">A Cytotoxic Activity of Clitoria ternatea Flower Tea with the Cinnamon and Lemongrass Oil Vapor against T47D Breast Cancer Cells</dc:title>
	<dc:creator xml:lang="en">Cahyono, Edy</dc:creator>
	<dc:creator xml:lang="en">Handayani, Tri </dc:creator>
	<dc:creator xml:lang="en">WH, Nugrahaningsih </dc:creator>
	<dc:creator xml:lang="en">Azid, Saffanah Binti Mohd Ab </dc:creator>
	<dc:creator xml:lang="en">Alighiri, Dante </dc:creator>
	<dc:creator xml:lang="en">Zaky, Adrian Maulana </dc:creator>
	<dc:creator xml:lang="en">Aisyah, Sabila </dc:creator>
	<dc:creator xml:lang="en">Permatasari, Bella </dc:creator>
	<dc:subject xml:lang="en">C. ternatea; chemopreventive; cinnamon; flower tea; lemongrass oil; T47D cells</dc:subject>
	<dc:description xml:lang="en">Breast cancer is a deadly disease for women. It is crucial to take preventive measures, one of which involves using natural ingredients as chemopreventive agents. Clitoria ternatea flowers, cinnamon, and lemongrass oil have been proven to have cytotoxic activity in several studies. This research aims to analyze the effect of adding cinnamon and lemongrass oil vapor to C. ternatea flower tea on the cytotoxic activity of T47D breast cancer cells. Cytotoxic activity testing was carried out colorimetrically using the MTT (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay method. The results of the research showed that there was a decrease in the IC50 value of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor. The IC50 value of C. ternatea flower tea without additional ingredients was the most potent with 14159 μg/mL, compared to 15 g addition of cinnamon with 1164 μg/mL; meanwhile, for 15 seconds of evaporation time for lemongrass, it was at 331 μg/mL, respectively This research shows the potential of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor as a chemopreventive agent against breast cancer cells.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-12-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/8480</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v16i3.8480</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 3 (2024): December 2024; 525-534</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/8480/2389</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>