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Anti-Inflammatory Effect of Phyllanthus niruri: A Meta-Analysis

Biosaintifika: Journal of Biology & Biology Education · Vol. 16 No. 2 (2024) · hlm. 332–341

DOI
10.15294/biosaintifika.v16i2.10823
ISSN
2338-7610, 2085-191X
Terbit
2024-08-15
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Many studies report on the role of Phyllanthus niruri as an anti-inflammatory and there are variations in the results in every research, so a meta-analysis study is needed to obtain accurate results. This study aims to conduct a meta-analysis of the effect of Phyllanthus niruri as an anti-inflammatory. This study uses a meta-analysis research design with data collection from 12 databases. The screening process was carried out according to PRISMA, then analyzed using Comprehensive Meta-Analysis Version 3 (CMA3). Funnel plot and Egger’s test were used as methods to measure publication bias. The articles used were 438 articles from various research journals. After going through screening, as many as 5 articles were eligible to be incorporated in the meta-analysis. Data were analyzed using a random effect model to calculate standardized means difference (SMD). The cytokines analyzed were TNF-α and IL-6 because both were discussed in at least 3 studies. Phyllanthus niruri affected the reduction of inflammatory cytokines with an effect size of SMD on TNF-α is -17,611 (95% CI -29,347, -5,875; p=0.003) and IL-6 is -3,263 (95% CI -5,403, -1,222; p = 0.003). The results of this meta-analysis strengthen the concept/theory that Phyllanthus niruri has the potential as an anti-inflammatory by reducing the inflammatory cytokines TNF-α and IL-6. These results strengthen the scientific basis for the use of Phyllanthus niruri as a supplement for the community to prevent inflammation.

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  • State University of Semarang
  • Indonesia International Institute for Life Sciences
  • National Research and Innovation Agency
  • Nagoya University
  • IPB University
  • Udayana University
  • Kementerian Kesehatan Republik Indonesia
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Rekan penulisOrganisasiArtikel bersama
Ari YuniastutiState University of Semarang6
Retno Damajanti SoejoedonoIPB University3
Nugrahaningsih WHState University of Semarang3
Siti Harnina BintariState University of Semarang2
Retno Sri IswariState University of Semarang2
Muchamad DafipState University of Semarang2
Maggy T SuhartonoAfiliasi tidak diketahui2
Khoerina SalwaState University of Semarang2
Anggun Try SetyaningsihState University of Semarang1
Wulan ChristijantiState University of Semarang1
Bagus Hammam FalahState University of Semarang1
Yenni Tyas Wulandari K. EState University of Semarang1
Prasetyo ListiajiState University of Semarang1
Farah Fitrotun NisaAfiliasi tidak diketahui1
Riska Laila MukaromahState University of Semarang1
Naina Rizki KenarniState University of Semarang1
Adi Franata JayaState University of Semarang1
Samsul NizarState University of Semarang1
Yustinus Ulung AnggraitoState University of Semarang1
Lili Astuti IsnaeniState University of Semarang1
Lusia Retno YulianaState University of Semarang1
Aditya MariantiState University of Semarang1
Retna UtamiState University of Semarang1
Enni Suwarsi RahayuState University of Semarang1
Putri AriestaState University of Semarang1
Ratih Puspita DewiAfiliasi tidak diketahui1
Karima WidiyastutiState University of Semarang1
Fidia FibrianaState University of Semarang1
Gusti Ngurah MahardikaUdayana University1
Wayan T I WibawanAfiliasi tidak diketahui1
Sri WahyuniState University of Semarang1
Arli Aditya ParikesitIndonesia International Institute for Life Sciences1
Nihayatul KarimahIndonesia International Institute for Life Sciences1
Fitri Arum SasiState University of Semarang1
Hari Rudijanto Indro WardonoKementerian Kesehatan Republik Indonesia1
Arum KartikadewiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Anti-Inflammatory Effect of Phyllanthus niruri: A Meta-Analysis</dc:title>
	<dc:creator xml:lang="en">Susanti, R</dc:creator>
	<dc:creator xml:lang="en">Fitriya, Farikhatun Nur </dc:creator>
	<dc:creator xml:lang="en">Kristamtini, K</dc:creator>
	<dc:creator xml:lang="en">Utomo, Didik Huswo </dc:creator>
	<dc:subject xml:lang="en">effect size, IL-6, inflammatory cytokines, standardized means difference, TNF-α</dc:subject>
	<dc:description xml:lang="en">Many studies report on the role of Phyllanthus niruri as an anti-inflammatory and there are variations in the results in every research, so a meta-analysis study is needed to obtain accurate results. This study aims to conduct a meta-analysis of the effect of Phyllanthus niruri as an anti-inflammatory. This study uses a meta-analysis research design with data collection from 12 databases. The screening process was carried out according to PRISMA, then analyzed using Comprehensive Meta-Analysis Version 3 (CMA3). Funnel plot and Egger’s test were used as methods to measure publication bias. The articles used were 438 articles from various research journals. After going through screening, as many as 5 articles were eligible to be incorporated in the meta-analysis. Data were analyzed using a random effect model to calculate standardized means difference (SMD). The cytokines analyzed were TNF-α and IL-6 because both were discussed in at least 3 studies. Phyllanthus niruri affected the reduction of inflammatory cytokines with an effect size of SMD on TNF-α is -17,611 (95% CI -29,347, -5,875; p=0.003) and IL-6 is -3,263 (95% CI -5,403, -1,222; p = 0.003). The results of this meta-analysis strengthen the concept/theory that Phyllanthus niruri has the potential as an anti-inflammatory by reducing the inflammatory cytokines TNF-α and IL-6. These results strengthen the scientific basis for the use of Phyllanthus niruri as a supplement for the community to prevent inflammation.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2024-08-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/10823</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v16i2.10823</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 16 No. 2 (2024): August 2024; 332-341</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v16i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/10823/1490</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>