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Parental Diet Exposure and High-Sugar-Fat Intake Effect on Glucose, Triglyceride and Cholesterol Hemolymph Level of Drosophila melanogaster across Five Generations

Biosaintifika: Journal of Biology & Biology Education · Vol. 17 No. 2 (2025) · hlm. 260–271

DOI
10.15294/biosaintifika.v17i2.23709
ISSN
2338-7610, 2085-191X
Terbit
2025-08-01
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Metabolic syndrome (MetS) is influenced by parental traits and diet. Drosophila melanogaster is a potential disease model organism, sharing physiology and genetic similarities with humans. Previous research had focused on Drosophila melanogaster as a model organism for obesity and diabetes, but not for MetS. This research aimed to determine the effect of both parental diet and high sugar fat (HSF) intake on glucose, cholesterol, and triglyceride hemolymph levels of Drosophila melanogaster. Wild flies were purified in either control (standard) or MetS media (extra 3% sucrose and palm oil). Seventy-five pairs were divided into 5 groups, according to parental origin and feeding media, and maintained in five generations (F1-F5). Glucose, triglyceride, and cholesterol levels were measured using a colorimetric assay in three replications of each generation per group. Glucose, triglyceride, and cholesterol levels were significantly different in all treatment than control groups, and across generations in each group (p<0.05). Higher glucose and triglyceride levels appeared in the youngest generation (F5) of all groups, and in the flies reared on HSF diets. Maternal HSF-exposed groups demonstrated a more pronounced impact of parental metabolic-state on the glucose and triglyceride levels of the earlier generation. These findings highlight that parental exposure to HSF and prolonged HSF intake independently and synergistically lead to persistent and amplified metabolic dysregulation across generations. Drosophila melanogaster, modeled in this study, represents a novel experimental organism that is suitable for studying the epigenetics of MetS, gaining more consideration for the metabolic health consequences of long-term dietary habits and parental metabolic-state.

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  • Yogyakarta State University
  • Sultan Idris Education University
  • University of Amsterdam
  • National Research and Innovation Agency
  • International Islamic University Malaysia
  • Hasanuddin University
  • Noordwest Ziekenhuisgroep
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Rekan penulisOrganisasiArtikel bersama
Aisyah Mohamad SharifSultan Idris Education University1
Balamuralithara BalakrishnanSultan Idris Education University1
Mohamed Noer Azhari AzmanSultan Idris Education University1
Mohd Ikhwan Hadi YaacobSultan Idris Education University1
Amalia Mulia UtamiHasanuddin University1
Gonca CinkaraUniversity of Amsterdam1
Max M. LokhorstUniversity of Amsterdam1
Onno J. de BoerUniversity of Amsterdam1
Chantal M.A.M. van der HorstUniversity of Amsterdam1
Lorine B. Meijer‐JornaNoordwest Ziekenhuisgroep1
Allard C. van der WalUniversity of Amsterdam1
Ahmad Kamal SudrajatState University of Malang1
Anggi Tias PratamaYogyakarta State University1
Atik KurniawatiYogyakarta State University1
Md Hoirul Azri PonariInternational Islamic University Malaysia1
Mohd Syahmi SallehInternational Islamic University Malaysia1
Muhamad YunusIndonesian Center for Agricultural Biotechnology and Genetic Resource Research and Development1
Mohd Syafik Mohamad HamdanUniversity College of Agroscience Malaysia1
Ni Putu Sri AsihNational Research and Innovation Agency1
Risha Amilia PratiwiNational Research and Innovation Agency1
Arief PriyadiNational Research and Innovation Agency1
Evy YuliantiYogyakarta State University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Parental Diet Exposure and High-Sugar-Fat Intake Effect on Glucose, Triglyceride and Cholesterol Hemolymph Level of Drosophila melanogaster across Five Generations</dc:title>
	<dc:creator xml:lang="en">Pertiwi, Kartika Ratna</dc:creator>
	<dc:creator xml:lang="en">Kuswandi, Paramita Cahyaningrum</dc:creator>
	<dc:creator xml:lang="en">Anazifa, Rizqa Devi</dc:creator>
	<dc:creator xml:lang="en">Zain, Haniza Hanim Mohd </dc:creator>
	<dc:subject xml:lang="en">parental diet</dc:subject>
	<dc:subject xml:lang="en">epigenetics</dc:subject>
	<dc:subject xml:lang="en">fruit flies</dc:subject>
	<dc:subject xml:lang="en">metabolic syndrome</dc:subject>
	<dc:subject xml:lang="en">model organism</dc:subject>
	<dc:description xml:lang="en">Metabolic syndrome (MetS) is influenced by parental traits and diet. Drosophila melanogaster is a potential disease model organism, sharing physiology and genetic similarities with humans. Previous research had focused on Drosophila melanogaster as a model organism for obesity and diabetes, but not for MetS. This research aimed to determine the effect of both parental diet and high sugar fat (HSF) intake on glucose, cholesterol, and triglyceride hemolymph levels of Drosophila melanogaster. Wild flies were purified in either control (standard) or MetS media (extra 3% sucrose and palm oil). Seventy-five pairs were divided into 5 groups, according to parental origin and feeding media, and maintained in five generations (F1-F5). Glucose, triglyceride, and cholesterol levels were measured using a colorimetric assay in three replications of each generation per group. Glucose, triglyceride, and cholesterol levels were significantly different in all treatment than control groups, and across generations in each group (p&amp;lt;0.05). Higher glucose and triglyceride levels appeared in the youngest generation (F5) of all groups, and in the flies reared on HSF diets. Maternal HSF-exposed groups demonstrated a more pronounced impact of parental metabolic-state on the glucose and triglyceride levels of the earlier generation. These findings highlight that parental exposure to HSF and prolonged HSF intake independently and synergistically lead to persistent and amplified metabolic dysregulation across generations. Drosophila melanogaster, modeled in this study, represents a novel experimental organism that is suitable for studying the epigenetics of MetS, gaining more consideration for the metabolic health consequences of long-term dietary habits and parental metabolic-state.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-08-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/23709</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v17i2.23709</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 17 No. 2 (2025): August 2025; 260-271</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v17i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/23709/5554</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
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