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Therapeutic Potential of Ethanol Extract from Durian Peel on Testes Microanatomy in Diabetic Male Rats

Biosaintifika: Journal of Biology & Biology Education · Vol. 17 No. 3 (2025) · hlm. 502–513

DOI
10.15294/biosaintifika.v17i3.25448
ISSN
2338-7610, 2085-191X
Terbit
2025-11-18
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Diabetes mellitus (DM) is a degenerative disease that can lead to complications such as testicular atrophy. As DM requires lifelong treatment, natural and safe therapeutic alternatives are needed. Durian peel, as a natural material, has potential. This study investigated the effects of ethanol extract of durian peel (EEDP) on testicular histology in diabetic rats. A total of 25 male Sprague-Dawley rats, aged 2 months and weight ±200 g, were randomly assigned to five groups: healthy (K0), diabetic (K1), and diabetic+EEDP at doses of 500 (K2), 750 (K3), and 1,000 mg/kgBW (K4), given orally for 28 days. After treatment, the rats were euthanized, and their testes were removed, weighed, and examined using hematoxylin-eosin staining. Observed variables included testis weight, seminiferous tubule diameter, epithelial thickness, and spermatogenesis stages. Statistical analysis ANOVA (α=0,05) showed significant improvements (p < 0,05) in the EEDP-treated groups. It is concluded that EEDP at doses of 500-1,000 mg/kgBW improved testicular structure in diabetic rats.. The novelty of this study lies in the utilization of durian peel ethanol extract at varying doses of 500–1,000 mg/kgBW as a natural therapy to improve testicular histological damage caused by diabetes. This study serves as a basis for the development of herbal antidiabetic drugs with protective effects on the reproductive system. The findings are expected to contribute to biomedical science and provide opportunities for utilizing durian peel waste as a value-added material for public health.

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  • State University of Semarang
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La Ode Irman JayaAfiliasi tidak diketahui5
Kustopo BudiraharjoAfiliasi tidak diketahui3
Zalfa AlfatinnisaAfiliasi tidak diketahui2
Mohammad Wahyu AndriyanAfiliasi tidak diketahui2
Muhammad Ragil SaputraAfiliasi tidak diketahui2
Endah Puji AstutiAfiliasi tidak diketahui2
Agus SubagioAfiliasi tidak diketahui2
Dwinanda BudiwardaniAfiliasi tidak diketahui2
Langlang HandayaniAfiliasi tidak diketahui1
Teguh DarsonoAfiliasi tidak diketahui1
Slamet HaryonoAfiliasi tidak diketahui1
Usrek Tani UtinaAfiliasi tidak diketahui1
Haydnn Caesha MaulanaAfiliasi tidak diketahui1
Musa Abdul HalimAfiliasi tidak diketahui1
Iklas Adi PangestuAfiliasi tidak diketahui1
Nabila Rakha PutriAfiliasi tidak diketahui1
Masturi MasturiState University of Semarang1
Yohannes SardjonoAfiliasi tidak diketahui1
Rio Agustian Gilang FernandoAfiliasi tidak diketahui1
Pratiwi DwijanantiAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Therapeutic Potential of Ethanol Extract from Durian Peel on Testes Microanatomy in Diabetic Male Rats</dc:title>
	<dc:creator xml:lang="en">Syakera, Cinta Etna </dc:creator>
	<dc:creator xml:lang="en">Isdadiyanto, Sri </dc:creator>
	<dc:creator xml:lang="en">Sunarno , Sunarno </dc:creator>
	<dc:creator xml:lang="en">Ermanjaya, Laode </dc:creator>
	<dc:subject xml:lang="en">ethanol extract</dc:subject>
	<dc:subject xml:lang="en">durian peel</dc:subject>
	<dc:subject xml:lang="en">diabetic</dc:subject>
	<dc:subject xml:lang="en">antihyperglycemic</dc:subject>
	<dc:subject xml:lang="en">testes  </dc:subject>
	<dc:description xml:lang="en">Diabetes mellitus (DM) is a degenerative disease that can lead to complications such as testicular atrophy. As DM requires lifelong treatment, natural and safe therapeutic alternatives are needed. Durian peel, as a natural material, has potential. This study investigated the effects of ethanol extract of durian peel (EEDP) on testicular histology in diabetic rats. A total of 25 male Sprague-Dawley rats, aged 2 months and weight ±200 g, were randomly assigned to five groups: healthy (K0), diabetic (K1), and diabetic+EEDP at doses of 500 (K2), 750 (K3), and 1,000 mg/kgBW (K4), given orally for 28 days. After treatment, the rats were euthanized, and their testes were removed, weighed, and examined using hematoxylin-eosin staining. Observed variables included testis weight, seminiferous tubule diameter, epithelial thickness, and spermatogenesis stages. Statistical analysis ANOVA (α=0,05) showed significant improvements (p &amp;lt; 0,05) in the EEDP-treated groups. It is concluded that EEDP at doses of 500-1,000 mg/kgBW improved testicular structure in diabetic rats.. The novelty of this study lies in the utilization of durian peel ethanol extract at varying doses of 500–1,000 mg/kgBW as a natural therapy to improve testicular histological damage caused by diabetes. This study serves as a basis for the development of herbal antidiabetic drugs with protective effects on the reproductive system. The findings are expected to contribute to biomedical science and provide opportunities for utilizing durian peel waste as a value-added material for public health.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-11-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/25448</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v17i3.25448</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 17 No. 3 (2025): November 2025; 502-513</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v17i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/25448/7092</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>