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Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity

Biosaintifika: Journal of Biology & Biology Education · Vol. 17 No. 2 (2025) · hlm. 349–357

DOI
10.15294/biosaintifika.v17i2.26258
ISSN
2338-7610, 2085-191X
Terbit
2025-08-01
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Noni fruit containing polysaccharides, has the potential to be developed into pharmaceutical products such as SPF syrup. The content of noni fruit polysaccharides is known to increase the proliferation of T lymphocyte cells, the regulation of the immune system molecularly, especially with regard to antibodies (IgG), CD4+, and CD8+, is still not widely studied. The aim of this study was to assess the impact of SPF syrup on the modulation of immunoglobulin G (IgG) and T lymphocytes. The study was conducted on female Wistar rats aged 8-9 months, which were given SPF syrup orally at doses of 25, 50, and 100 mg/kgBB for 31 days. Mice were vaccinated against hepatitis B every week. Blood samples were taken on day 31 to measure IgG levels by the ELISA method and T cells (CD4+ and CD8+) by flow cytometry. The results showed that SPF administration had a significant effect on IgG levels (p 0.05). Histopathological examination showed that long-term induction of hepatitis B caused damage to the liver and kidney, but SPF did not affect the condition of these organs. SPF that contains polysaccharides can be an innovative component in immunostimulant formulations.

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31 penulis · 111 tautan kepenulisan bersama · 41 lintas organisasi

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  • Universitas Medika Suherman
  • Universitas Gadjah Mada
  • Sekolah Tinggi Ilmu Kesehatan Sint Carolus
  • Universitas Muhammadiyah Banten
  • Universidade de Díli
  • Kementerian Kesehatan Republik Indonesia
  • Krida Wacana Christian University
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Rekan penulisOrganisasiArtikel bersama
Afif Wahyudi HidayatUniversitas Medika Suherman2
Nico SuwarnoUniversitas Medika Suherman2
Nurali NuraliUniversitas Medika Suherman2
Mohammad ZakyAfiliasi tidak diketahui1
Rika SurtianaAfiliasi tidak diketahui1
Edria Benita TampubolonAfiliasi tidak diketahui1
Anna Nur AzizahAfiliasi tidak diketahui1
Edy MeiyantoUniversitas Gadjah Mada1
Sari HaryantiKementerian Kesehatan Republik Indonesia1
Dhania NovitasariUniversitas Gadjah Mada1
Herwandhani PutriUniversitas Gadjah Mada1
Beni LestariUniversitas Gadjah Mada1
Annisa NovarinaUniversitas Gadjah Mada1
Meirizky Zulharini S.Universitas Gadjah Mada1
Rikat RaksamiharjaUniversitas Gadjah Mada1
Khairunnisa SyUniversitas Gadjah Mada1
Agnes Pude LepuenSekolah Tinggi Ilmu Kesehatan Sint Carolus1
Sada RasmadaSekolah Tinggi Ilmu Kesehatan Sint Carolus1
Ernawati ErnawatiKrida Wacana Christian University1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity</dc:title>
	<dc:creator xml:lang="en">Anwar, La Ode Muhammad</dc:creator>
	<dc:creator xml:lang="en">Sasmito, Ediati </dc:creator>
	<dc:creator xml:lang="en">Rasydy, La Ode Akbar </dc:creator>
	<dc:creator xml:lang="en">Ismoyowati, Tri Wahyuni </dc:creator>
	<dc:creator xml:lang="en">Hashim, Salma Hilmy Rusydi </dc:creator>
	<dc:creator xml:lang="en">Siregar, Rohani </dc:creator>
	<dc:creator xml:lang="en">Hutagaol, Emmelia Kristina </dc:creator>
	<dc:creator xml:lang="en">Bratajaya, Cicilia Nony Ayuningsih </dc:creator>
	<dc:creator xml:lang="en">Sartika, Aprilina </dc:creator>
	<dc:creator xml:lang="en">Sanjaya, Dandi </dc:creator>
	<dc:creator xml:lang="en">Rohmah, Hajar Nur Fathur </dc:creator>
	<dc:creator xml:lang="en">Ximenes, Joao Manuel Correia </dc:creator>
	<dc:subject xml:lang="en">CD4+</dc:subject>
	<dc:subject xml:lang="en">CD8+</dc:subject>
	<dc:subject xml:lang="en">IgG</dc:subject>
	<dc:subject xml:lang="en">Immunomodulator</dc:subject>
	<dc:subject xml:lang="en">Noni fruit</dc:subject>
	<dc:subject xml:lang="en">Polysaccharide</dc:subject>
	<dc:description xml:lang="en">Noni fruit containing polysaccharides, has the potential to be developed into pharmaceutical products such as SPF syrup. The content of noni fruit polysaccharides is known to increase the proliferation of T lymphocyte cells, the regulation of the immune system molecularly, especially with regard to antibodies (IgG), CD4+, and CD8+, is still not widely studied. The aim of this study was to assess the impact of SPF syrup on the modulation of immunoglobulin G (IgG) and T lymphocytes. The study was conducted on female Wistar rats aged 8-9 months, which were given SPF syrup orally at doses of 25, 50, and 100 mg/kgBB for 31 days. Mice were vaccinated against hepatitis B every week. Blood samples were taken on day 31 to measure IgG levels by the ELISA method and T cells (CD4+ and CD8+) by flow cytometry. The results showed that SPF administration had a significant effect on IgG levels (p&amp;lt;0.05), and there were no significant changes in T lymphocyte cells (CD4+, CD8+) (p&amp;gt;0.05). Histopathological examination showed that long-term induction of hepatitis B caused damage to the liver and kidney, but SPF did not affect the condition of these organs. SPF that contains polysaccharides can be an innovative component in immunostimulant formulations.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-08-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/26258</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v17i2.26258</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 17 No. 2 (2025): August 2025; 349-357</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v17i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/26258/5544</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>