Jurnal
Hypoxia-Induced Mesenchymal Stem Cell-Derived Exosome Enhance TGF-β, PDGF, and Hair Growth in Alopecia-Like Rat Models
Biosaintifika: Journal of Biology & Biology Education · Vol. 18 No. 1 (2026) · hlm. 104–115
- ISSN
- 2338-7610, 2085-191X
- Terbit
- 2026-04-28
- Penerbit
- Universitas Negeri Semarang
- Bahasa
- eng
Abstrak
Alopecia disrupts hair growth, leading to hair loss and baldness. Hypoxia-induced mesenchymal stem cell (MSC)–derived exosomes have emerged as a promising therapeutic alternative. These exosomes can modulate inflammatory responses and potentially enhance the expression of TGF-β and PDGF, key growth factors involved in hair follicle regeneration. This study aims to investigate the effects of hypoxia-induced MSC exosomes on TGF-β and PDGF expression in a fluconazole-induced alopecia-like rat model. Five groups were used: K1 (healthy control), K2 (fluconazole-induced, 0.9% NaCl), K3 (Minoxidil), K4 (100 µL hypoxia-induced MSC exosomes), and K5 (200 µL hypoxia-induced MSC exosomes). Skin samples were collected on day 15 post-treatment for analysis of TGF-β and PDGF levels using enzyme-linked immunosorbent assay (ELISA). Based on the analysis, the highest levels of TGF-β and PDGF were found in K1, followed by K5 and K4, while the lowest levels were observed in K2. This study finds that the single-dose injection of 200 µl of EH-MSCs daily for 14 days significantly increases the levels of TGF-β and PDGF in the skin, which contributes to improved hair growth. This study assumes that TGF-β and PDGF potentially improve hair growth through immunomodulation and a pro-angiogenic mechanism. These findings suggest that hypoxia-induced MSC exosomes represent a promising therapeutic strategy for alopecia and may be developed broadly for regenerative medicine targeting chronic inflammation-based skin disorders. However, further studies are needed to explore more about various cytokine and their function that relevance for alopecia and other inflammation-related skin conditions.
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24 penulis · 58 tautan kepenulisan bersama · 2 lintas organisasi
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- University of Brawijaya
- Universitas Islam Indragiri
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- Organisasi berbeda
- Organisasi sama
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Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Hurriyatul Fitriyah | University of Brawijaya | 2 |
| Agung Setia Budi | University of Brawijaya | 2 |
| Rizal Maulana | University of Brawijaya | 2 |
| Agung Putra | Afiliasi tidak diketahui | 2 |
| Muhammad Rheza Caesardi | University of Brawijaya | 1 |
| Jeffry Atur Firdaus | University of Brawijaya | 1 |
| Sabriansyah Rizqika Akbar | University of Brawijaya | 1 |
| Agung Setiabudi | Universitas Islam Indragiri | 1 |
| Fahmi Erza | University of Brawijaya | 1 |
| Rakhmadhany Primananda | University of Brawijaya | 1 |
| Naufal Mohamad Ghifary | Afiliasi tidak diketahui | 1 |
| Dewi Paskalia Andi Djawaria | Afiliasi tidak diketahui | 1 |
| Adji Prayitno Setiadi | Afiliasi tidak diketahui | 1 |
| Carolina Kiwik Rahardja | Afiliasi tidak diketahui | 1 |
| Sugeng Ibrahim | Afiliasi tidak diketahui | 1 |
| Nur Dina Amalina | Afiliasi tidak diketahui | 1 |
| Alisia Martha Dewi | Afiliasi tidak diketahui | 1 |
| Setyo Trisnasi | Afiliasi tidak diketahui | 1 |
| Chodijah Chodijah | Afiliasi tidak diketahui | 1 |
| Hadi Sarosa | Afiliasi tidak diketahui | 1 |
| Y. Titik Haryati | Afiliasi tidak diketahui | 1 |
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