Jurnal
GC-MS Profiles, Anti-inflammatory and Antibacterial Activities of Mucuna pruriens Seed Against Gastrointestinal Pathogens
Biosaintifika: Journal of Biology & Biology Education · Vol. 18 No. 1 (2026) · hlm. 78–92
- ISSN
- 2338-7610, 2085-191X
- Terbit
- 2026-04-28
- Penerbit
- Universitas Negeri Semarang
- Bahasa
- eng
Abstrak
Escherichia coli and Bacillus cereus are pathogenic bacteria commonly implicated in gastrointestinal infection (GI). Severe GI can lead to some gastrointestinal diseases, such as diarrhea, gastroenteritis, and chronic inflammation. While antibiotic therapy remains the standard treatment, the rise in antimicrobial resistance (AMR) cases necessitates alternative therapeutic approaches. This study aimed to investigate the antibacterial and anti-inflammatory potential of Velvet bean (Mucuna pruriens L.) and to identify its bioactive compounds using gas chromatography-mass spectrometry (GC-MS). Antibacterial activity was assessed against E. coli and B. cereus using the disc diffusion method. Meanwhile, anti-inflammatory activity was measured by the red blood cell membrane stabilization method at extract concentrations of 15, 60, 250, and 1000 ppm. Antibacterial effectiveness was determined by measuring the diameter of inhibition zones, while anti-inflammatory potential was quantified through stability percentages. The results showed that the velvet bean’s ethanolic extract had antibacterial activity against both bacteria, with the strongest inhibition observed at 100% extract concentration, producing inhibition zones of 9.2 mm on E. coli and 7.15 mm on B. cereus. For the anti-inflammatory assay, the 1000 ppm extract demonstrated the highest stability value (76.36%), nearly equivalent to the standard non-steroidal anti-inflammatory drug (NSAID), ibuprofen (76.35% at 120 ppm), as a positive control. GC-MS analysis revealed the presence of 18 bioactive compounds in the velvet bean extract, classified into nine chemical groups, which are mostly known for their antimicrobial and anti-inflammatory potential. These findings highlight the potential of M. pruriens to address gastrointestinal infections, particularly those caused by E. coli and B. cereus, as well as its anti-inflammatory effect. This also contributes to achieving sustainable development goals (SDGs), especially to encourage good health in the community through utilizing local resources for herbal-based treatment.
Kata kunci
Jaringan kolaborasi para penulis
37 penulis · 152 tautan kepenulisan bersama · 35 lintas organisasi
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- Sunan Gunung Djati State Islamic University Bandung
- Padjadjaran University
- University of Manchester
- Sekolah Tinggi Analis Bakti Asih
- Universitas Islam Negeri Alauddin Makassar
- Organisasi Riset Hayati dan Lingkungan
- Universitas Mathla'ul Anwar Banten
- Organisasi lain
- Afiliasi tidak diketahui
- Organisasi berbeda
- Organisasi sama
- Afiliasi tidak diketahui
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Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Opik Taupiqurrohman | Sekolah Tinggi Analis Bakti Asih | 4 |
| Tri Cahyanto | Sunan Gunung Djati State Islamic University Bandung | 4 |
| Siska Tridesianti | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Ayuni Adawiyah | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Rahmat Taufiq Mustahiq Akbar | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Dicky Dicky | Afiliasi tidak diketahui | 3 |
| Pameila Qaulan Tsaqila Madani | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Rindi Meldania | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Sophia Eka Tisnawati | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Ita Fitriyyah | Sunan Gunung Djati State Islamic University Bandung | 3 |
| Astuti Kusumorini | Sunan Gunung Djati State Islamic University Bandung | 2 |
| Cecep Hidayat | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Opik Taupik Kurahman | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Mashuri Masri | Universitas Islam Negeri Alauddin Makassar | 1 |
| Astri Yuliawati | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Lusi Haerunnisa | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Ateng Supriyatna | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Asep Supriadin | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Fauziah Qurota Ayuni | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Epa Paujiah | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Maratus Solikha | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Muhammad Yusuf | Padjadjaran University | 1 |
| Toto Subroto | Padjadjaran University | 1 |
| Sukma Nuswantara | Organisasi Riset Hayati dan Lingkungan | 1 |
| Dina Amalia | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Firman Rezaldi | Universitas Mathla'ul Anwar Banten | 1 |
| Ismi Farah Syarifah | Universitas Islam Negeri Sultan Maulana Hasanuddin Banten | 1 |
| Ghea Gema Adzani | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Isma Dwi Kurniawan | Sunan Gunung Djati State Islamic University Bandung | 1 |
| Opik Taufiqurrahman4 | Afiliasi tidak diketahui | 1 |
| Nisrina Hasna | Sunan Gunung Djati State Islamic University Bandung | 1 |
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