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Mosaic of Drosophila Behavior Due to Bisphenol-A Exposure: From Hyperactivity to Aversion

Biosaintifika: Journal of Biology & Biology Education · Vol. 17 No. 3 (2025) · hlm. 488–501

DOI
10.15294/biosaintifika.v17i3.34229
ISSN
2338-7610, 2085-191X
Terbit
2025-11-18
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Bisphenol-A (BPA) is classified as an endocrine-disrupting chemical that is widely found in everyday food. However, various studies have reported inconsistent results regarding the effects of this exposure on behavior. This study aimed to evaluate how dose, genetic background, and duration of exposure interact to shape behavioral responses in Drosophila melanogaster exposed to BPA. Three strains (Wild-type, white-eye, and black-body) were cultured on a medium containing 0, 0.25, and 0.5 mg/mL BPA for two generations. Before exposure (G0), after the first generation of exposure (G1), and after the second generation of exposure (G2), three behaviors were measured: larval crawling speed, number of larval contractions, and larval exploration distance. Repeated-measures ANOVA revealed a non-monotonic pattern in behavioral responses. Each behavior exhibited distinct sensitivities to treatment factors, and complex interactions were observed between genetic factors, dose, and time (generation). Furthermore, the effects of BPA are not general but rather specific to the type of behavior observed. Generational effects are evident in some behavioral data. In addition, fly strain plays a role in determining the effect of exposure on behavioral responses.

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  • State University of Malang
  • University of Mataram
  • Universiti Brunei Darussalam
  • National Yang Ming Chiao Tung University
  • Universitas Islam Negeri Maulana Malik Ibrahim
  • Fiji National University
  • Yogyakarta State University
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Rekan penulisOrganisasiArtikel bersama
Susriyati MahanalState University of Malang7
Hendra SusantoNational Yang Ming Chiao Tung University5
Asep Bayu Dani NandiyantoAfiliasi tidak diketahui3
Fatchur RohmanState University of Malang3
Risti RagadhitaAfiliasi tidak diketahui2
Aloysius Duran CorebimaState University of Malang2
Muhammad Asy’ariUniversity of Mataram2
Agus Mukti WibowoState University of Malang1
Sugeng UtayaState University of Malang1
W. WahjoediState University of Malang1
Saiful AminUniversitas Islam Negeri Maulana Malik Ibrahim1
Ravinesh Rohit PrasadFiji National University1
Herdiyana FitrianiUniversity of Mataram1
İnsih WilujengYogyakarta State University1
Ni Nyoman Sri Putu VerawatiUniversity of Mataram1
Saiful PrayogiAfiliasi tidak diketahui1
Hikmawati HikmawatiUniversitas Muslim Buton1
Dwi candra setiawanAfiliasi tidak diketahui1
A D CorebimaAfiliasi tidak diketahui1
Ibrahim BafadalAfiliasi tidak diketahui1
Achmad SupriyantoAfiliasi tidak diketahui1
Syamsul HadiAfiliasi tidak diketahui1
Sudaryono SudaryonoAfiliasi tidak diketahui1
Mujiyono WiryotinoyoAfiliasi tidak diketahui1
Syarifatul MubarakUniversitas Islam Negeri Mataram1
Ratna RatnaAfiliasi tidak diketahui1
Lia HandayaniAfiliasi tidak diketahui1
Sri ApriliaAfiliasi tidak diketahui1
Nasrul ArahmanAfiliasi tidak diketahui1
Amri AminAfiliasi tidak diketahui1
Ulfia HumairaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Mosaic of Drosophila Behavior Due to Bisphenol-A Exposure: From Hyperactivity to Aversion</dc:title>
	<dc:creator xml:lang="en">Fauzi, Ahmad</dc:creator>
	<dc:creator xml:lang="en">Ramadhan, Muhamad Justitia</dc:creator>
	<dc:creator xml:lang="en">Kharomah, Sindi</dc:creator>
	<dc:creator xml:lang="en">Kharomah, Sinta</dc:creator>
	<dc:creator xml:lang="en">Zahrah, Natasya Adiba</dc:creator>
	<dc:creator xml:lang="en">Setiawan, Deny</dc:creator>
	<dc:creator xml:lang="en">Buroidah, Hikmah</dc:creator>
	<dc:creator xml:lang="en">Bilad, Muhammad Roil </dc:creator>
	<dc:creator xml:lang="en">Zubaidah, Siti</dc:creator>
	<dc:subject xml:lang="en">Activity</dc:subject>
	<dc:subject xml:lang="en">BPA contamination</dc:subject>
	<dc:subject xml:lang="en">Drosophila melanogaster</dc:subject>
	<dc:subject xml:lang="en">locomotor</dc:subject>
	<dc:subject xml:lang="en">neurobehavior</dc:subject>
	<dc:description xml:lang="en">Bisphenol-A (BPA) is classified as an endocrine-disrupting chemical that is widely found in everyday food. However, various studies have reported inconsistent results regarding the effects of this exposure on behavior. This study aimed to evaluate how dose, genetic background, and duration of exposure interact to shape behavioral responses in Drosophila melanogaster exposed to BPA. Three strains (Wild-type, white-eye, and black-body) were cultured on a medium containing 0, 0.25, and 0.5 mg/mL BPA for two generations. Before exposure (G0), after the first generation of exposure (G1), and after the second generation of exposure (G2), three behaviors were measured: larval crawling speed, number of larval contractions, and larval exploration distance. Repeated-measures ANOVA revealed a non-monotonic pattern in behavioral responses. Each behavior exhibited distinct sensitivities to treatment factors, and complex interactions were observed between genetic factors, dose, and time (generation). Furthermore, the effects of BPA are not general but rather specific to the type of behavior observed. Generational effects are evident in some behavioral data. In addition, fly strain plays a role in determining the effect of exposure on behavioral responses.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-11-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/34229</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v17i3.34229</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 17 No. 3 (2025): November 2025; 488-501</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v17i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/34229/7091</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>