Melola Discovery

← Melola Discovery

Jurnal

Analysis of ellagic acid response in Nephelium lappaceum peel extract in the obesity rat model

Biosaintifika: Journal of Biology & Biology Education · Vol. 18 No. 1 (2026) · pp. 153–165

DOI
10.15294/biosaintifika.v18i1.37039
ISSN
2338-7610, 2085-191X
Published
2026-04-28
Publisher
Universitas Negeri Semarang
Language
eng

Abstract

Naphelium lappaceum L or Rambutan in Indonesian, fruit peel has been identified as a potential source of polyphenolic compounds, including ellagic acid, geraniin, and corilagin. Ellagic acid has been reported to have strong antioxidant activity, inhibit adipogenesis, increase lipid oxidation, and reduce plasma lipid concentrations in obese animal models. This study aimed to analyze the response of ellagic acid contained in N. lappaceum peel extract on lipid profiles and liver histology in obese rat models. Twenty-five male Sprague-Dawley rats were divided into five groups: normal (P1), obese (P2), ellagic acid (P3), O-RPE (Obese rats treated with RPE) 15 mg/kgBW (P4), and O-RPE 30 mg/kgBW (P5). Treatment was administered for 30 days. The results showed that administration of ellagic acid and RPS (O-RPE) significantly improved metabolic parameters in obese rats. ANOVA analysis revealed lower LDL (p < 0.05), reduced triglycerides, and improved liver histology scores in treatment groups compared to the obese control, while other parameters showed favorable but non‑significant trends. In conclusion, ellagic acid in RPE demonstrates potential as a herbal anti-obesity agent by improving lipid profiles and liver tissue structure. This research highlights the innovative use of N. lappaceum peel as a source of bioactive compounds for obesity management, an area that remains underexplored. This research supports SDGs 3 (Good Health and Well‑being) by offering natural interventions for obesity, and SDGs 12 (Responsible Consumption and Production) by promoting sustainable use of agricultural waste.

Keywords

Collaboration network of the authors

40 authors · 110 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • State University of Semarang
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Aditya MariantiAffiliation unknown4
Ari YuniastutiState University of Semarang4
Wulan ChristijantiAffiliation unknown4
Endah PeniatiState University of Semarang4
LisdianaAffiliation unknown2
R. SusantiAffiliation unknown2
Addina Nur LuthfianiAffiliation unknown2
Nirmala Al FatiahAffiliation unknown2
Ngurah Made Dharna PutraAffiliation unknown1
Eny Hartadiyati WHAffiliation unknown1
Liya Aliyah NurainiAffiliation unknown1
Khilya Mufrida AmalaAffiliation unknown1
Fitria ShalsabilaAffiliation unknown1
Revinta Nur Aulia RochlyAffiliation unknown1
Bagus Hammam FalahAffiliation unknown1
SITI QOMARIAHAffiliation unknown1
Istikhomah IstikhomahAffiliation unknown1
Ita Dwi RafitaAffiliation unknown1
Risma Romaulina SimarmataAffiliation unknown1
Isti FadahAffiliation unknown1
Izzatun NufusAffiliation unknown1
Mira Putri AgustinAffiliation unknown1
Sausan Inas AfaninAffiliation unknown1
Lailatun Nisa' Nisa'Affiliation unknown1
Yudi PriyantoAffiliation unknown1
Eny SusantiAffiliation unknown1
Mutiara Diah NisaAffiliation unknown1
Khoerina SalwaAffiliation unknown1
Didik Huswo UtomoAffiliation unknown1
Edy CahyonoState University of Semarang1
Tri HandayaniAffiliation unknown1
Saffanah Binti Mohd Ab AzidAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Analysis of ellagic acid response in Nephelium lappaceum peel extract in the obesity rat model</dc:title>
	<dc:creator xml:lang="en">Lisdiana, Lisdiana</dc:creator>
	<dc:creator xml:lang="en">Lamondo, Djuna </dc:creator>
	<dc:creator xml:lang="en">Basar, Annisaa </dc:creator>
	<dc:creator xml:lang="en">WH, Nugrahaningsih </dc:creator>
	<dc:creator xml:lang="en">Naimah, Mirtaati </dc:creator>
	<dc:creator xml:lang="en">Damayanti, Yofi Ersyada </dc:creator>
	<dc:creator xml:lang="en">Aulia, Amalia Wilda </dc:creator>
	<dc:creator xml:lang="en">Salsabila, Fitria </dc:creator>
	<dc:subject xml:lang="en">Elagic acid</dc:subject>
	<dc:subject xml:lang="en">obesity</dc:subject>
	<dc:subject xml:lang="en">Naphelium lappaceum L peel extract</dc:subject>
	<dc:description xml:lang="en"> Naphelium lappaceum L or Rambutan in Indonesian, fruit peel has been identified as a potential source of polyphenolic compounds, including ellagic acid, geraniin, and corilagin. Ellagic acid has been reported to have strong antioxidant activity, inhibit adipogenesis, increase lipid oxidation, and reduce plasma lipid concentrations in obese animal models. This study aimed to analyze the response of ellagic acid contained in N. lappaceum peel extract on lipid profiles and liver histology in obese rat models.  Twenty-five male Sprague-Dawley rats were divided into five groups: normal (P1), obese (P2), ellagic acid (P3), O-RPE (Obese rats treated with RPE) 15 mg/kgBW (P4), and O-RPE 30 mg/kgBW (P5). Treatment was administered for 30 days. The results showed that administration of ellagic acid and RPS (O-RPE) significantly improved metabolic parameters in obese rats. ANOVA analysis revealed lower LDL (p &amp;lt; 0.05), reduced triglycerides, and improved liver histology scores in treatment groups compared to the obese control, while other parameters showed favorable but non‑significant trends. In conclusion, ellagic acid in RPE demonstrates potential as a herbal anti-obesity agent by improving lipid profiles and liver tissue structure. This research highlights the innovative use of N. lappaceum peel as a source of bioactive compounds for obesity management, an area that remains underexplored. This research supports SDGs 3 (Good Health and Well‑being) by offering natural interventions for obesity, and SDGs 12 (Responsible Consumption and Production) by promoting sustainable use of agricultural waste.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2026-04-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/37039</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v18i1.37039</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 18 No. 1 (2026): April 2026; 153-165</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v18i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/37039/9703</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>