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Protective Effects of Curculigo latifolia Root Extract on Testicular Function in Mice Exposed to 7,12-Dimethylbenz(A)Anthracene

Biosaintifika: Journal of Biology & Biology Education · Vol. 18 No. 1 (2026) · hlm. 185–197

DOI
10.15294/biosaintifika.v18i1.38549
ISSN
2338-7610, 2085-191X
Terbit
2026-04-28
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

The testis, a vital reproductive organ in males, is highly susceptible to damage from chemotherapy. The root of Curculigo latifolia contains secondary metabolites that have potential as anticancer agents and protective agents for reproductive health. This study aims to evaluate the protective potential of crude extract from C. latifolia in suppressing testicular carcinogenesis induced by DMBA in vivo. This study employed a completely randomized design with five treatment groups, including negative and positive controls, as well as three treatment groups receiving doses of C. latifolia root extract at 300, 600, and 900 mg/Kg body weight. Testicular carcinogenesis was induced by oral administration of DMBA at a dose of 20 mg/Kg body weight twice a week for six weeks. The data of sperm quality, including motility, viability, sperm concentration, and testicular microanatomical structures, analysed by ANOVA one-way test, revealed significant effects from oral administration of C. latifolia root extract (p < 0.05). Overall, C. latifolia root extract improves sperm quality and protects the testicular microanatomical structure against DMBA exposure. Novelty in this study explores the local herbal agent potential (C. latifolia root extract), decreasing reproductive damage and alopecia from DMBA carcinogenic effects. Thus, these findings directly contribute to reaching Sustainable Development Goal 3 (SDG3) by ensuring healthy lives and promoting well-being in all aspects for all ages.

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Aulia SanovaAfiliasi tidak diketahui4
Abu BakarAfiliasi tidak diketahui3
Harizon HarizonAfiliasi tidak diketahui2
Heri RetnawatiYogyakarta State University2
Eva BanowatiAfiliasi tidak diketahui1
Salim MaisarohAfiliasi tidak diketahui1
Puji HardatiAfiliasi tidak diketahui1
M Imron RosyadiAfiliasi tidak diketahui1
Suroso SurosoAfiliasi tidak diketahui1
Khairul IsmiAfiliasi tidak diketahui1
Yudha Surya PutraAfiliasi tidak diketahui1
Nabillah NatasyahAfiliasi tidak diketahui1
Abdul RahimAfiliasi tidak diketahui1
Hetty Rufaidah SiambatonAfiliasi tidak diketahui1
Erlinawati ErlinawatiAfiliasi tidak diketahui1
Dwi KusriniAfiliasi tidak diketahui1
Sugiharto SugihartoAfiliasi tidak diketahui1
Awalya AwalyaAfiliasi tidak diketahui1
Sailal ArimiAfiliasi tidak diketahui1
Dian Permatasari Kusuma DayuAfiliasi tidak diketahui1
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Afrida AfridaAfiliasi tidak diketahui1
Pinta MurniAfiliasi tidak diketahui1
Estitika EstitikaAfiliasi tidak diketahui1
Roslina TurnipAfiliasi tidak diketahui1
Muhammad Alfi Nur IlahiAfiliasi tidak diketahui1
Nanda Kumala RatihAfiliasi tidak diketahui1
Anisah AnisahAfiliasi tidak diketahui1
M. Dwi Wiwik ErnawatiAfiliasi tidak diketahui1
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Intan Aulia SariAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/biosaintifika/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Protective Effects of Curculigo latifolia Root Extract on Testicular Function in Mice Exposed to 7,12-Dimethylbenz(A)Anthracene</dc:title>
	<dc:creator xml:lang="en">Haryanto, Haryanto</dc:creator>
	<dc:creator xml:lang="en">Muharram, Luthfia Hastiani</dc:creator>
	<dc:creator xml:lang="en">Sutandi, Agus</dc:creator>
	<dc:creator xml:lang="en">Aprillia, Cusiyani</dc:creator>
	<dc:creator xml:lang="en">Amirullah, Saepul Muhyi</dc:creator>
	<dc:creator xml:lang="en">Pradita, Faisal Anggi </dc:creator>
	<dc:subject xml:lang="en">7,12-dimethylbenz[a]anthracene (DMBA)</dc:subject>
	<dc:subject xml:lang="en">Curculigo latifolia root extract</dc:subject>
	<dc:subject xml:lang="en">BALB/c mice</dc:subject>
	<dc:subject xml:lang="en">sperm quality</dc:subject>
	<dc:subject xml:lang="en">testicular microanatomy</dc:subject>
	<dc:description xml:lang="en">The testis, a vital reproductive organ in males, is highly susceptible to damage from chemotherapy. The root of Curculigo latifolia contains secondary metabolites that have potential as anticancer agents and protective agents for reproductive health. This study aims to evaluate the protective potential of crude extract from C. latifolia in suppressing testicular carcinogenesis induced by DMBA in vivo. This study employed a completely randomized design with five treatment groups, including negative and positive controls, as well as three treatment groups receiving doses of C. latifolia root extract at 300, 600, and 900 mg/Kg body weight. Testicular carcinogenesis was induced by oral administration of DMBA at a dose of 20 mg/Kg body weight twice a week for six weeks. The data of sperm quality, including motility, viability, sperm concentration, and testicular microanatomical structures, analysed by ANOVA one-way test, revealed significant effects from oral administration of C. latifolia root extract (p &amp;lt; 0.05). Overall, C. latifolia root extract improves sperm quality and protects the testicular microanatomical structure against DMBA exposure. Novelty in this study explores the local herbal agent potential (C. latifolia root extract), decreasing reproductive damage and alopecia from DMBA carcinogenic effects. Thus, these findings directly contribute to reaching Sustainable Development Goal 3 (SDG3) by ensuring healthy lives and promoting well-being in all aspects for all ages.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2026-04-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/biosaintifika/article/view/38549</dc:identifier>
	<dc:identifier>10.15294/biosaintifika.v18i1.38549</dc:identifier>
	<dc:source xml:lang="en">Biosaintifika: Journal of Biology &amp; Biology Education; Vol. 18 No. 1 (2026): April 2026; 185-197</dc:source>
	<dc:source>2338-7610</dc:source>
	<dc:source>2085-191X</dc:source>
	<dc:source>10.15294/biosaintifika.v18i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/biosaintifika/article/view/38549/9537</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Biosaintifika: Journal of Biology &amp; Biology Education</dc:rights>
</oai_dc:dc>