Jurnal
Antiproliferative and Apoptosis-Inducing Effects of Iodine Molecule in Differentiated Primary Thyroid Cancer Cells: In Vitro Study
Biosaintifika: Journal of Biology & Biology Education · Vol. 18 No. 1 (2026) · hlm. 166–173
- ISSN
- 2338-7610, 2085-191X
- Terbit
- 2026-04-28
- Penerbit
- Universitas Negeri Semarang
- Bahasa
- eng
Abstrak
Thyroid cancer poses a persistent clinical challenge, particularly when conventional therapies fall short. Growing evidence suggests that molecular iodine (I₂) may exert direct antitumor effects beyond its classical role in thyroid hormone synthesis. This study evaluated the antiproliferative and apoptosis-inducing effects of I₂ on primary cell cultures derived from differentiated thyroid cancer tissue and established dose- and time-response relationships. Primary cultures were exposed to I₂ at concentrations of 5, 10, 20, 40, 80, and 100 µM for 24, 48, and 72 hours. Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, with IC₅₀ calculated accordingly. Apoptosis was characterized by acridine orange/propidium iodide (AO/PI) double-staining, analyzed by fluorescence microscopy and ImageJ software. I₂ demonstrated clear antiproliferative and apoptotic activity in a dose- and time-dependent manner. The strongest effect appeared at 100 µM after 72 hours, reducing viability to 1.39% (p < 0.001). At the IC₅₀ of 2.09 µM, iodine significantly suppressed proliferation and induced apoptosis, with an apoptosis rate of 81.77% ± 12.24% (p = 0.004). These findings confirm the meaningful antineoplastic potential of I₂ against differentiated thyroid cancer cells. This study supports SDG 3 (Good Health and Well-Being), contributing to efforts to develop more equitable, effective cancer treatment options and to reduce cancer-related morbidity globally.
Kata kunci
Jaringan kolaborasi para penulis
22 penulis · 66 tautan kepenulisan bersama · 21 lintas organisasi
Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.
- Andalas University
- National Nuclear Energy Agency of Indonesia
- Padjadjaran University
- Dr. Hasan Sadikin General Hospital
- Universitas Airlangga
- Afiliasi tidak diketahui
- Organisasi berbeda
- Organisasi sama
- Afiliasi tidak diketahui
- Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Putri Ariani | Afiliasi tidak diketahui | 1 |
| Dedy Kurnia | Afiliasi tidak diketahui | 1 |
| Rudy Afriant | Afiliasi tidak diketahui | 1 |
| Rina Gustia | Afiliasi tidak diketahui | 1 |
| Rikarni | Afiliasi tidak diketahui | 1 |
| Rinal Effendi | Afiliasi tidak diketahui | 1 |
| Martalena Ramli | National Nuclear Energy Agency of Indonesia | 1 |
| Veronika Yulianti Susilo | National Nuclear Energy Agency of Indonesia | 1 |
| Sri Setiyowati | National Nuclear Energy Agency of Indonesia | 1 |
| Johan S. Masjhur | Padjadjaran University | 1 |
| Tri Hanggono Achmad | Padjadjaran University | 1 |
| Mohd. Jamil | Andalas University | 1 |
| Hidayat Arifin | Universitas Airlangga | 1 |
| Boby Febri Krisdianto | Andalas University | 1 |
| Leni Merdawati | Andalas University | 1 |
| Wirsma Arif Harahap | Andalas University | 1 |
Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.