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Kratom (Mitragyna speciosa): Medicinal Marvel or Menace? Assessing Potency, Risk, and Future Prospect of Herbal Medicine

Indonesian Journal of Chemical Science · Vol. 13 No. 1 (2024)

ISSN
2502-6844, 2252-6951
Terbit
2024-05-28
Penerbit
Prodi Kimia
Bahasa
eng

Abstrak

Kratom (Mitragyna speciosa) boasts a rich historical legacy as an herbal plant employed across generations for diverse therapeutic purposes, including pain relief, inflammation mitigation, anti-diarrheal effects, cough suppression, alleviation of fatigue, and anti-anxiety and antidepressant properties. Despite its acclaimed medicinal versatility, this plant harbors psychoactive attributes, thereby posing the risk of misuse and potential dependence, along with withdrawal effects. The alkaloid composition of kratom, featuring opioid receptor agonist properties, underscores its analgesic efficacy, thereby carrying a risk of dependence and withdrawal akin to other opioid agonists. Beyond its role as an opioid agonist, the analgesic mechanism of kratom extends to additional complementary pathways, presenting a potential superiority to morphine. Notably, kratom constituents inhibit key drug-metabolizing enzymes (CYP) and the multidrug transporter, p-glycoprotein, potentially leading to heightened levels of co-administered drugs that are substrates for these proteins, presenting a potential risk of adverse outcomes, including fatality. Given the perceived imbalance of risks versus benefits, there arises a rationale for the prohibition of kratom use as an herbal remedy. However, the exploration of purified drugs derived from kratom isolates remains a promising avenue for research, with the potential to surpass standard pharmaceutical interventions.

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  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Muhammad Athfal NuransyahAfiliasi tidak diketahui1
Dzulrifaad Ubaidillah Al AfzaAfiliasi tidak diketahui1
Annisa Aulia SavitriAfiliasi tidak diketahui1
Willy Tirza EdenAfiliasi tidak diketahui1
Samuel Budi Wardhana KusumaAfiliasi tidak diketahui1
Nanik WijayatiState University of Semarang1
SudarminState University of Semarang1
Sri Anggini WahyuningsihAfiliasi tidak diketahui1
Endah WidhihastutiAfiliasi tidak diketahui1
Sitarina WidyariniAfiliasi tidak diketahui1
Nanang FakhrudinAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/ijcs/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 5 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Kratom (Mitragyna speciosa): Medicinal Marvel or Menace? Assessing Potency, Risk, and Future Prospect of Herbal Medicine</dc:title>
	<dc:creator xml:lang="en">Ni'ma, Neli Syahida</dc:creator>
	<dc:subject xml:lang="en">Kratom</dc:subject>
	<dc:subject xml:lang="en">Mitragyna speciosa</dc:subject>
	<dc:subject xml:lang="en">Mitragynine</dc:subject>
	<dc:subject xml:lang="en">Opioid</dc:subject>
	<dc:subject xml:lang="en">Analgetic</dc:subject>
	<dc:description xml:lang="en">Kratom (Mitragyna speciosa) boasts a rich historical legacy as an herbal plant employed across generations for diverse therapeutic purposes, including pain relief, inflammation mitigation, anti-diarrheal effects, cough suppression, alleviation of fatigue, and anti-anxiety and antidepressant properties. Despite its acclaimed medicinal versatility, this plant harbors psychoactive attributes, thereby posing the risk of misuse and potential dependence, along with withdrawal effects. The alkaloid composition of kratom, featuring opioid receptor agonist properties, underscores its analgesic efficacy, thereby carrying a risk of dependence and withdrawal akin to other opioid agonists. Beyond its role as an opioid agonist, the analgesic mechanism of kratom extends to additional complementary pathways, presenting a potential superiority to morphine. Notably, kratom constituents inhibit key drug-metabolizing enzymes (CYP) and the multidrug transporter, p-glycoprotein, potentially leading to heightened levels of co-administered drugs that are substrates for these proteins, presenting a potential risk of adverse outcomes, including fatality. Given the perceived imbalance of risks versus benefits, there arises a rationale for the prohibition of kratom use as an herbal remedy. However, the exploration of purified drugs derived from kratom isolates remains a promising avenue for research, with the potential to surpass standard pharmaceutical interventions.
 </dc:description>
	<dc:publisher xml:lang="en">Prodi Kimia</dc:publisher>
	<dc:date>2024-05-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/ijcs/article/view/2443</dc:identifier>
	<dc:source xml:lang="en">Indonesian Journal of Chemical Science; Vol. 13 No. 1 (2024)</dc:source>
	<dc:source>2502-6844</dc:source>
	<dc:source>2252-6951</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/ijcs/article/view/2443/440</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Indonesian Journal of Chemical Science</dc:rights>
</oai_dc:dc>