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Development and Validation of Infrared Spectroscopy Methods for Rutin Compound Analysis

Indonesian Journal of Chemical Science · Vol. 10 No. 2 (2021) · hlm. 102–107

DOI
10.15294/ijcs.v10i2.47959
ISSN
2502-6844, 2252-6951
Terbit
2021-09-03
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Rutin is a glycoside resulting from the condensation of the aglycone quercetin with the sugar rutinose. Some study show that rutin can reduce cardiac hypertrophy and improve heart health. Appropiate levels can optimize rutin performance, it is necessary to develop methods for rutin assays and their validation. This study aims to develop an analytical method for rutin compound with FTIR and their validity. The FTIR methods has several advantages including simple preparation, fast scanning, high resolution, does not take long, and without the use of hazardous reagents and can be used for qualitative and quantitative analysis at the same time. The standard rutin with mass variation (0.5-1.75 mg) was mixed homogeneously with KBr so that the total mass was 16 mg. The mixture of rutin and KBr then made into pellets with a hydraulic machine so that transparent pellets were obtained. Measurement were carried out at wave number 4000-400 cm-1 with 8 scanning. Methods validation include linearity, LoD, LoQ, and precision test. Based on the result of the analysis, the typical peak of rutin compounds is in the wave number range of 900-690 cm-1 namely aromatic C-H. Rutin had linearity, LoD, and LoQ of 0.8719, 0.7 mg, and 2.5 mg, and %RSD repeatability 17.68 % and %RSD reproducibility 17.62 %.

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  • State University of Semarang
  • Universitas Islam Negeri Antasari Banjarmasin
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
Agung Tri PrasetyaState University of Semarang5
Eko Budi SusatyoAfiliasi tidak diketahui3
Wisnu SunartoAfiliasi tidak diketahui2
Charisma ChalifAfiliasi tidak diketahui1
F. ‪Widhi MahatmantiAfiliasi tidak diketahui1
Riska Putri MawarniAfiliasi tidak diketahui1
HarjonoAfiliasi tidak diketahui1
Erwin Budi PamungkasAfiliasi tidak diketahui1
Gayuh Ganata Imam SofyanAfiliasi tidak diketahui1
Riera Asti WulaningrumAfiliasi tidak diketahui1
Himnil KhusnaAfiliasi tidak diketahui1
Novilla AnggasariAfiliasi tidak diketahui1
Winarni PratjojoAfiliasi tidak diketahui1
Arfah Ratna Puri GustianAfiliasi tidak diketahui1
Ervina Nur HidayatiAfiliasi tidak diketahui1
Nova Shintia BokauAfiliasi tidak diketahui1
Dyah SetyaningrumAfiliasi tidak diketahui1
Aurelia Anggit Widya MunikaAfiliasi tidak diketahui1
Endang SusilaningsihState University of Semarang1
Zumrotus Sa’adahAfiliasi tidak diketahui1
Suryat Hadi KusumaAfiliasi tidak diketahui1
Amallia KurniawatiAfiliasi tidak diketahui1
Puji RizqiAfiliasi tidak diketahui1
Ridho PrasetyoDiponegoro University1
Martin SulistyaniAfiliasi tidak diketahui1
Nuril HudaUniversitas Islam Negeri Antasari Banjarmasin1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/ijcs/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Development and Validation of Infrared Spectroscopy Methods for Rutin Compound Analysis</dc:title>
	<dc:creator>Auha, Nydia Ashfi</dc:creator>
	<dc:creator>Alauhdin, Mohammad</dc:creator>
	<dc:description xml:lang="en-US">Rutin is a glycoside resulting from the condensation of the aglycone quercetin with the sugar rutinose. Some study show that rutin can reduce cardiac hypertrophy and improve heart health. Appropiate levels can optimize rutin performance, it is necessary to develop methods for rutin assays and their validation. This study aims to develop an analytical method for rutin compound with FTIR and their validity. The FTIR methods has several advantages including simple preparation, fast scanning, high resolution, does not take long, and without the use of hazardous reagents and can be used for qualitative and quantitative analysis at the same time. The standard rutin with mass variation (0.5-1.75 mg) was mixed homogeneously with KBr so that the total mass was 16 mg. The mixture of rutin and KBr then made into pellets with a hydraulic machine so that transparent pellets were obtained. Measurement were carried out at wave number 4000-400 cm-1 with 8 scanning. Methods validation include linearity, LoD, LoQ, and precision test. Based on the result of the analysis, the typical peak of rutin compounds is in the wave number range of 900-690 cm-1 namely aromatic C-H. Rutin had linearity, LoD, and LoQ of 0.8719, 0.7 mg, and 2.5 mg, and %RSD repeatability 17.68 % and %RSD reproducibility 17.62 %.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2021-09-03</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/ijcs/article/view/47959</dc:identifier>
	<dc:identifier>10.15294/ijcs.v10i2.47959</dc:identifier>
	<dc:source xml:lang="en-US">Indonesian Journal of Chemical Science; Vol 10 No 2 (2021); 102-107</dc:source>
	<dc:source>2502-6844</dc:source>
	<dc:source>2252-6951</dc:source>
	<dc:source>10.15294/ijcs.v10i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/ijcs/article/view/47959/19893</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Indonesian Journal of Chemical Science</dc:rights>
</oai_dc:dc>