Noninvasive blood glucose monitoring system based on near-infrared method

Abstract

Diabetes is considered one of the life-threatening diseases in the world which need continuous monitoring to avoid the complication of diabetes. There is a need to develop a non-invasive monitoring system that avoids the risk of infection problems and pain caused by invasive monitoring techniques. This paper presents a method for developing a noninvasive technique to predict the blood glucose concentration (BCG) based on the Near-infrared (NIR) light sensor. A prototype is developed using a finger sensor based on LED of 940 nm wavelength to collect photoplethysmography (PPG) signal which is variable depending on the glucose concentration variance, a module circuit to preprocess PPG signals is realized, which includes an amplifier and analog filter circuits, an Arduino UNO is used to analog-to-digital conversion. A digital Butterworth filterer is used to remove PPG signal trends, then detect the PPG data peaks to determine the relationship between the PPG signal and (BCG) and use it as input parameters to build the calibration model based on linear regression. Experiments show that the Root Mean Squares Error (RMSE) of the prediction is between 8.264mg/dL and 13.166 mg/dL, the average of RMSE is about 10.44mg/dL with a correlation coefficient (R^2) of 0.839, it is observed that the prediction of glucose concentration is in the clinically acceptable region of the standard Clark Error Grid (CEG).