Melola Discovery

← Melola Discovery

Jurnal

Physical Exercise And Epigenetic: Molecular Mechanisms

Journal of Sport Science and Fitness · Vol. 11 No. 2 (2025) · hlm. 110–125

DOI
10.15294/jssf.v11i2.34037
ISSN
2745-5718, 2252-6528
Terbit
2025-11-18
Penerbit
Universitas Negeri Semarang
Bahasa
eng

Abstrak

Introduction: Physical exercise is associated with an active lifestyle and offers numerous health benefits. Recent research has shown that physical exercise also influences gene expression through epigenetic mechanisms such as DNA methylation, histone modification, mRNA, and microRNA expression. These changes contribute to physiological changes and disease prevention. Objectives: This review aims to explain how physical activity can affect a person's epigenetic changes to have an impact on the prevention of chronic diseases. Method: This study is a literature review using databases such as PubMed from 2015 to 2025. Result: the review revealed that physical activity can cause epigenetic changes at the stage of DNA methylation, histone modification, RNA methylation and MiRNA. Physical activity modulates DNA methylation, affecting genes related to metabolism and immune function. Understanding this pathway is the basis for developing personalized exercise programs as interventions for the prevention and therapy of chronic diseases. Understanding this pathway is the basis for developing personalized exercise programs as interventions for the prevention and therapy of diseases. Conclusion: This study reveals the relevance of epigenetic changes to physical activity as an alternative non-pharmacological therapy because it is accompanied by a perspective in choosing the type of physical activity that suits the body's condition as a step in implementing a more precise health pattern.

Kata kunci

Jaringan kolaborasi para penulis

5 penulis · 10 tautan kepenulisan bersama

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • State University of Makassar
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/jssf/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Physical Exercise And Epigenetic: Molecular Mechanisms</dc:title>
	<dc:creator xml:lang="en">Anggraeni. M, Andi Sri Dewi</dc:creator>
	<dc:creator xml:lang="en">Arimbi</dc:creator>
	<dc:creator xml:lang="en">A.Anggriani</dc:creator>
	<dc:creator xml:lang="en">Lesbatta, Kezia Josawel</dc:creator>
	<dc:creator xml:lang="en">Indriani</dc:creator>
	<dc:subject xml:lang="en">Physical Exercise</dc:subject>
	<dc:subject xml:lang="en"> Epigenetics</dc:subject>
	<dc:subject xml:lang="en">Molecular</dc:subject>
	<dc:description xml:lang="en">Introduction: Physical exercise is associated with an active lifestyle and offers numerous health benefits. Recent research has shown that physical exercise also influences gene expression through epigenetic mechanisms such as DNA methylation, histone modification, mRNA, and microRNA expression. These changes contribute to physiological changes and disease prevention. Objectives: This review aims to explain how physical activity can affect a person's epigenetic changes to have an impact on the prevention of chronic diseases. Method: This study is a literature review using databases such as PubMed from 2015 to 2025. Result: the review revealed that physical activity can cause epigenetic changes at the stage of DNA methylation, histone modification, RNA methylation and MiRNA. Physical activity modulates DNA methylation, affecting genes related to metabolism and immune function. Understanding this pathway is the basis for developing personalized exercise programs as interventions for the prevention and therapy of chronic diseases. Understanding this pathway is the basis for developing personalized exercise programs as interventions for the prevention and therapy of diseases. Conclusion: This study reveals the relevance of epigenetic changes to physical activity as an alternative non-pharmacological therapy because it is accompanied by a perspective in choosing the type of physical activity that suits the body's condition as a step in implementing a more precise health pattern.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang</dc:publisher>
	<dc:date>2025-11-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/jssf/article/view/34037</dc:identifier>
	<dc:identifier>10.15294/jssf.v11i2.34037</dc:identifier>
	<dc:source xml:lang="en">Journal of Sport Science and Fitness; Vol. 11 No. 2 (2025): JSSF: Journal of Sport Science and Fitness; 110-125</dc:source>
	<dc:source>2745-5718</dc:source>
	<dc:source>2252-6528</dc:source>
	<dc:source>10.15294/jssf.v11i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/jssf/article/view/34037/7075</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Journal of Sport Science and Fitness</dc:rights>
</oai_dc:dc>