Melola Discovery

← Melola Discovery

Jurnal

Unsuccessful Drug-Resistant TB Treatment Outcomes among Patients with Short-Term Regimen in Central Java, Indonesia

Jurnal Kesehatan Masyarakat · Vol. 20 No. 4 (2025) · hlm. 641–652

DOI
10.15294/kemas.v20i4.9483
ISSN
2355-3596, 1858-1196
Terbit
2025-04-30
Penerbit
Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)
Bahasa
eng

Abstrak

Tuberculosis which shows resistance to various types of drugs poses a significant burden in efforts to prevent and control tuberculosis globally. Since 2020, guidelines from the WHO have recommended a shorter treatment with an all-oral regimen for Drug Resistant Tuberculosis (DR-TB), with the inclusion of bedaquiline instead of an injectable agent. However, the treatment success rate for DR-TB in Indonesia is still low. This study aimed to determine factors contributing to unsuccessful DR-TB treatment using STR in Central Java. This was a nested case-control study of 412 DR-TB patients enrolled with a Short-Term Regimen, registered in 2021 to 2023 who had treatment results in a subset of the Tuberculosis Information System cohort data. Independent variables analyzed included age, gender, patient employment status, history of previous TB treatment, DM status, HIV status, resistance pattern, initial sputum examination results, drug side effects, treatment initiation interval, body mass index, and BPJS ownership status. Statistical analysis was done using SPSS version 22 software, with logistic regression analysis to identify the determinants. The determinant of unsuccessful treatment outcome in Central Java Province which is 51.04% was the positive results of initial sputum examination of treatment (aOR=10.501; 95%CI=5.056-21.807), drug side effects (aOR=1.853; 95%CI=1,000-3.436), obesity (aOR=3.115; 95%CI=1.188-8.166) and BPJS non-possession status (aOR=2.213; 95%CI=0.932-5.255). More strategies are needed to improve the success of treatment with STR.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 129 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Jenderal Soedirman University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Radi RadiAfiliasi tidak diketahui3
Mahalul AzamAfiliasi tidak diketahui2
Arulita Ika FibrianaAfiliasi tidak diketahui2
Intan ZainafreeAfiliasi tidak diketahui2
Agus PurwantoAfiliasi tidak diketahui2
Hery WinarsiAfiliasi tidak diketahui2
Sulistyawati SulistyawatiAfiliasi tidak diketahui2
Tri Wahyuni SukesiAfiliasi tidak diketahui2
Surahma Asti MulasariAfiliasi tidak diketahui2
Rokhmayanti RokhmayantiAfiliasi tidak diketahui2
Annastya KinasihAfiliasi tidak diketahui2
Pipit Nur AzijahAfiliasi tidak diketahui2
Hanifah SyairaAfiliasi tidak diketahui2
Dhiya Azizah AsmaraAfiliasi tidak diketahui2
Susina YatapyaAfiliasi tidak diketahui2
Devi OctavianaAfiliasi tidak diketahui2
Budi AjiJenderal Soedirman University2
Nadia SyukriaAfiliasi tidak diketahui1
Silfia AddinaAfiliasi tidak diketahui1
Suratman SuratmanAfiliasi tidak diketahui1
Ashlikhatul Fuadah Al HasyimAfiliasi tidak diketahui1
Casmuti CasmutiAfiliasi tidak diketahui1
Irma ZaimatudduniaAfiliasi tidak diketahui1
Widya Hary CahyatiAfiliasi tidak diketahui1
Dina Nur Anggraini NingrumAfiliasi tidak diketahui1
Henky Yoga PrasetyaAfiliasi tidak diketahui1
Abdul HakamAfiliasi tidak diketahui1
Alek JusranAfiliasi tidak diketahui1
Muhamad IrsamAfiliasi tidak diketahui1
Sri Wahyuni NingsihAfiliasi tidak diketahui1
Agustin Putri RahayuAfiliasi tidak diketahui1
Mustika Suci SusilastutiAfiliasi tidak diketahui1
Amanda Hesti PratiwiAfiliasi tidak diketahui1
Tonny SundjayaAfiliasi tidak diketahui1
Roma YulianaAfiliasi tidak diketahui1
Intan NurfatihahAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/kemas/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Unsuccessful Drug-Resistant TB Treatment Outcomes among Patients with Short-Term Regimen in Central Java, Indonesia</dc:title>
	<dc:creator xml:lang="en">Ardiani, Intan Henda</dc:creator>
	<dc:creator xml:lang="en">Rejeki, Dwi Sarwani Sri </dc:creator>
	<dc:creator xml:lang="en">Wijayanti , Siwi Pramatama Mars </dc:creator>
	<dc:creator xml:lang="en">Saefurrohim, Muhamad Zakki</dc:creator>
	<dc:subject xml:lang="en">Drug-Resistant TB</dc:subject>
	<dc:subject xml:lang="en">Unsuccessful Treatment</dc:subject>
	<dc:subject xml:lang="en">Short-Term Regimen</dc:subject>
	<dc:description xml:lang="en">Tuberculosis which shows resistance to various types of drugs poses a significant burden in efforts to prevent and control tuberculosis globally. Since 2020, guidelines from the WHO have recommended a shorter treatment with an all-oral regimen for Drug Resistant Tuberculosis (DR-TB), with the inclusion of bedaquiline instead of an injectable agent. However, the treatment success rate for DR-TB in Indonesia is still low. This study aimed to determine factors contributing to unsuccessful DR-TB treatment using STR in Central Java. This was a nested case-control study of 412 DR-TB patients enrolled with a Short-Term Regimen, registered in 2021 to 2023 who had treatment results in a subset of the Tuberculosis Information System cohort data. Independent variables analyzed included age, gender, patient employment status, history of previous TB treatment, DM status, HIV status, resistance pattern, initial sputum examination results, drug side effects, treatment initiation interval, body mass index, and BPJS ownership status. Statistical analysis was done using SPSS version 22 software, with logistic regression analysis to identify the determinants. The determinant of unsuccessful treatment outcome in Central Java Province which is 51.04% was the positive results of initial sputum examination of treatment (aOR=10.501; 95%CI=5.056-21.807), drug side effects (aOR=1.853; 95%CI=1,000-3.436), obesity (aOR=3.115; 95%CI=1.188-8.166) and BPJS non-possession status (aOR=2.213; 95%CI=0.932-5.255). More strategies are needed to improve the success of treatment with STR.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)</dc:publisher>
	<dc:date>2025-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/kemas/article/view/9483</dc:identifier>
	<dc:identifier>10.15294/kemas.v20i4.9483</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kesehatan Masyarakat; Vol. 20 No. 4 (2025); 641-652</dc:source>
	<dc:source>2355-3596</dc:source>
	<dc:source>1858-1196</dc:source>
	<dc:source>10.15294/kemas.v20i4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/kemas/article/view/9483/5121</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jurnal Kesehatan Masyarakat</dc:rights>
</oai_dc:dc>