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The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial

Jurnal Kesehatan Masyarakat · Vol. 20 No. 4 (2025) · hlm. 841–847

DOI
10.15294/kemas.v20i4.19307
ISSN
2355-3596, 1858-1196
Terbit
2025-04-30
Penerbit
Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)
Bahasa
eng

Abstrak

Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.

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  • Padjadjaran University
  • Maranatha Christian University
  • Universitas Garut
  • Universitas Jenderal Achmad Yani
  • Universitas Gadjah Mada
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Rekan penulisOrganisasiArtikel bersama
Nawadhir FauzanPadjadjaran University3
Shela SalsabilaPadjadjaran University2
N Anna Sakinah Liana RahmawatiPadjadjaran University1
Mutie ZahraniPadjadjaran University1
Diflaa Kayla NisrinaPadjadjaran University1
Anzalna RachmanPadjadjaran University1
Fashli Kamilain SupyansuriPadjadjaran University1
Alya Puteri Agustina PribadiPadjadjaran University1
Natasya ParameswariPadjadjaran University1
Sugiarto PuradisastraMaranatha Christian University1
Regina Aurellia LimijayaMaranatha Christian University1
Angelica Rosa Septiana HartonoMaranatha Christian University1
Dhania NovitasariUniversitas Gadjah Mada1
Riska PrasetiawatiUniversitas Garut1
Meilia SuhermanUniversitas Garut1
Cecep SuhandiPadjadjaran University1
Ersa FadhilahPadjadjaran University1
Nurfianti SilviaPadjadjaran University1
Annisa AtusholihahPadjadjaran University1
Randy Rassi PrayogaPadjadjaran University1
Sandra MegantaraPadjadjaran University1
Yohana Faustine YuarsaPadjadjaran University1
Garneta Izzati Herdy PutriPadjadjaran University1
Valeri Belliana SanjayaPadjadjaran University1
Akmal Taufiqur RahmanPadjadjaran University1
Nissa Andjani KusmawidiyantiAfiliasi tidak diketahui1
Nazma Mumtaz SidikPadjadjaran University1
Nabillah FauziyyahPadjadjaran University1
Difla 'Afina Ghifari SuhendarPadjadjaran University1
Sunani SunaniPadjadjaran University1
Maya AndaniPadjadjaran University1
Asilla Mauri Ramdini KamaludinPadjadjaran University1
Nyai Ayu Sylfia Stannia Puspitasari HelmiPadjadjaran University1
Kaila Keyshia MeiPadjadjaran University1
Yunitasya GuspiraPadjadjaran University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/kemas/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial</dc:title>
	<dc:creator xml:lang="en">Tjahjani, Susy</dc:creator>
	<dc:creator xml:lang="en">Hermanto, Faizal</dc:creator>
	<dc:creator xml:lang="en">Muchtaridi, Muchtaridi</dc:creator>
	<dc:creator xml:lang="en">Aulifa, Diah Lia</dc:creator>
	<dc:creator xml:lang="en">Ahsanul Haq, Fahmi</dc:creator>
	<dc:subject xml:lang="en">alpha-mangostin chitosan alginate nanoparticles</dc:subject>
	<dc:subject xml:lang="en">ED50</dc:subject>
	<dc:subject xml:lang="en">antimalarial activity</dc:subject>
	<dc:subject xml:lang="en">in vivo</dc:subject>
	<dc:subject xml:lang="en">berghei malaria</dc:subject>
	<dc:description xml:lang="en">Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)</dc:publisher>
	<dc:date>2025-04-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/kemas/article/view/19307</dc:identifier>
	<dc:identifier>10.15294/kemas.v20i4.19307</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kesehatan Masyarakat; Vol. 20 No. 4 (2025); 841-847</dc:source>
	<dc:source>2355-3596</dc:source>
	<dc:source>1858-1196</dc:source>
	<dc:source>10.15294/kemas.v20i4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/kemas/article/view/19307/5134</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Jurnal Kesehatan Masyarakat</dc:rights>
</oai_dc:dc>