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Methanol Extract of Rue Leaves on Body Fat Composition, Insulin Resistance, and Leptin Gene Expression

Jurnal Kesehatan Masyarakat · Vol. 21 No. 3 (2026) · hlm. 566–578

DOI
10.15294/kemas.v21i3.29957
ISSN
2355-3596, 1858-1196
Terbit
2026-01-30
Penerbit
Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)
Bahasa
eng

Abstrak

Obesity is a multifactorial and complex disorder characterized by excessive accumulation of adipose tissue, with negative health outcomes. Rue leaves (Ruta graveolens) contain active compounds that have activity as anti-obesity, such as rutacridone. Therefore, this study aims to determine the effect of Rue Leaves Methanol Extract (MER) on Obesity Index (OI), Body Fat Content (BFC), Wet Fat Weight (WFW), Insulin level (IL), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Homeostatic Model Assessment for β-cell Function (HOMA-β) and Leptin Gene Expression (LGE) in obesity model rats (OR). This study was an experimental animal study with a pretest-posttest control group design using 24 male Sprague-Dawley rats, which were randomly divided into six groups. The normal group (N) was male rats + standard rat feed (BR-2). The negative and positive groups (NC and PC) were OR + BR-2 + 1 mL 0.9% NaCl or 0.6 mg/kgBW pure rutacridone, respectively. Treatment groups (T1-T3) were OR + BR-2 + 80, 100, or 200 mg/kg BW MERL for 30 days. Our results demonstrated that MER administration significantly reduced OI, BFC, IL and HOMA-IR also significantly increased HOMA-β level with p ˂ 0.05, compared to the NC group in a dose-dependent manner. Our data also showed low expression of leptin gene and WFW in all treatment groups. In conclusion, MER administration reduces OI, BFC, WFW, IL, HOMA-IR and LGE while increasing HOMA-β in male obese rats.

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  • Sebelas Maret University
  • Universitas Syiah Kuala
  • State University of Semarang
  • National Research and Innovation Agency
  • IPB University
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Rekan penulisOrganisasiArtikel bersama
Fista UtamiSebelas Maret University2
Alfian Abdul RajabAfiliasi tidak diketahui2
Fitriana FitrianaUniversitas Syiah Kuala1
Sri SulistyowatiSebelas Maret University1
Soetrisno SoetrisnoSebelas Maret University1
Astri PurwantiSebelas Maret University1
Sugiarto SugiartoSebelas Maret University1
Brian WasitaSebelas Maret University1
Tantri Febriana PutriSebelas Maret University1
Bambang PurwantoState University of Semarang1
Hafi NurinasariSebelas Maret University1
SajidanSebelas Maret University1
Didik Tulus SubektiNational Research and Innovation Agency1
Irma Isnafia AriefIPB University1
Anantha SenaSebelas Maret University1
Ambar MudigdoSebelas Maret University1
Artini PangastutiSebelas Maret University1
Putri Regita AnggrainiSebelas Maret University1
Siti Lusi Arum SariSebelas Maret University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/kemas/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Methanol Extract of Rue Leaves on Body Fat Composition, Insulin Resistance, and Leptin Gene Expression</dc:title>
	<dc:creator xml:lang="en">Haryta, Florensia Syntesa</dc:creator>
	<dc:creator xml:lang="en">Listyawati, Shanti</dc:creator>
	<dc:creator xml:lang="en">Indarto, Dono</dc:creator>
	<dc:subject xml:lang="en">Rue leaves, Insulin Resistance, Leptin gene expression, Obesity</dc:subject>
	<dc:description xml:lang="en">Obesity is a multifactorial and complex disorder characterized by excessive accumulation of adipose tissue, with negative health outcomes. Rue leaves (Ruta graveolens) contain active compounds that have activity as anti-obesity, such as rutacridone. Therefore, this study aims to determine the effect of Rue Leaves Methanol Extract (MER) on Obesity Index (OI), Body Fat Content (BFC), Wet Fat Weight (WFW), Insulin level (IL), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Homeostatic Model Assessment for β-cell Function (HOMA-β) and Leptin Gene Expression (LGE) in obesity model rats (OR). This study was an experimental animal study with a pretest-posttest control group design using 24 male Sprague-Dawley rats, which were randomly divided into six groups. The normal group (N) was male rats + standard rat feed (BR-2). The negative and positive groups (NC and PC) were OR + BR-2 + 1 mL 0.9% NaCl or 0.6 mg/kgBW pure rutacridone, respectively. Treatment groups (T1-T3) were OR + BR-2 + 80, 100, or 200 mg/kg BW MERL for 30 days. Our results demonstrated that MER administration significantly reduced OI, BFC, IL and HOMA-IR also significantly increased HOMA-β level with p ˂ 0.05, compared to the NC group in a dose-dependent manner. Our data also showed low expression of leptin gene and WFW in all treatment groups. In conclusion, MER administration reduces OI, BFC, WFW, IL, HOMA-IR and LGE while increasing HOMA-β in male obese rats.
 </dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)</dc:publisher>
	<dc:date>2026-01-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/kemas/article/view/29957</dc:identifier>
	<dc:identifier>10.15294/kemas.v21i3.29957</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kesehatan Masyarakat; Vol. 21 No. 3 (2026); 566 - 578</dc:source>
	<dc:source>2355-3596</dc:source>
	<dc:source>1858-1196</dc:source>
	<dc:source>10.15294/kemas.v21i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/kemas/article/view/29957/9084</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Jurnal Kesehatan Masyarakat</dc:rights>
</oai_dc:dc>