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Milk-based Drinks containing Lactic Acid Bacteria on Gut Dysbiosis and Birth Weight from Undernourished Pregnant Rats

Jurnal Kesehatan Masyarakat · Vol. 22 No. 1 (2026) · hlm. 163–170

DOI
10.15294/kemas.v22i1.47429
ISSN
2355-3596, 1858-1196
Terbit
2026-09-26
Penerbit
Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)
Bahasa
eng

Abstrak

Lactic Acid Bacteria (LAB) can be an alternative intervention to help improve pregnancy outcomes. This study aimed to examine the effects of milk-based drinks (MBD) containing a single strain, namely Lactobacillus casei Shirota strain, and MBD containing multiple strains, namely Lactobacillus delbrueckii subsp. Bulgaricus, Lactobacillus paracasei, Lactobacillus rhamnosus, and Streptococcus thermophi- lus to improve gut dysbiosis and offspring birthweight in malnourished pregnant rats, conducted at the Experimental Animal Laboratory from 2020 to 2021. The sample consisted of female rats that were induced with malnutrition and mated. Twenty four female Sprague Dawley rats, aged 7-8 weeks, weighing 150-250 grams, were randomly divided into one negative control group (A0) and three malnourished groups. The malnourished groups consisted of the positive control group (A1), MBD-LcS group (A2), and MBD-multi strain group (A3). The intervention was administered for 19 days. Data was analyzed using ANOVA. Results showed that administering MBDs significantly affected total coliform bacteria (p<0.05). Moreover, it significantly affected the offspring’s birth weight. The highest birth weight was found in the A3 group (5.18±0.88 g). Overall, prodiving MBDs containing beneficial bacteria significantly improved total coliform bacteria and pregnancy outcomes. Thus, it can help reduce nutritional and health problems in the future.

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  • IPB University
  • Universitas Negeri Surabaya
  • Universitas Airlangga
  • National Research and Innovation Agency
  • Universitas Esa Unggul
  • Institut Agama Islam Negeri Kendari
  • Universitas Binawan
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Rekan penulisOrganisasiArtikel bersama
Rimbawan RimbawanIPB University5
Mira DewiIPB University3
Dodik BriawanIPB University2
Erry Yudhya MulyaniUniversitas Esa Unggul2
Budi Iman SantosoUniversitas Airlangga2
Katrin RoositaIPB University2
Amay Ni’matuzzahroh Al HidayahUniversitas Negeri Surabaya1
Nastiti Fikri BrillianiUniversitas Negeri Surabaya1
Rini HariantiAfiliasi tidak diketahui1
RimbawanAfiliasi tidak diketahui1
Rini HariantiAfiliasi tidak diketahui1
Poppy ZuhrahAfiliasi tidak diketahui1
Rahmawati RahmawatiInstitut Agama Islam Negeri Kendari1
Firdaus FirdausNational Research and Innovation Agency1
Veni IndrawatiUniversitas Negeri Surabaya1
Gerarda Lisa YuwantiUniversitas Negeri Surabaya1
Lini Anisfatus SholihahUniversitas Negeri Surabaya1
Arum Reyan SafitriUniversitas Airlangga1
Angga RizqiawanUniversitas Binawan1
Suci AmaliaSekolah Tinggi Ilmu Kesehatan Holistik1
Dwinita Wikan UtamiNational Research and Innovation Agency1
Budi Indra SetiawanIPB University1
Farah FauziyyahIPB University1
Fitria HidayantiNasional University1
Aviani HarfikaAfiliasi tidak diketahui1
Listhia Hardiati RahmanAfiliasi tidak diketahui1
Elsa Carla AziziIPB University1
Asep RusyanaUniversitas Syiah Kuala1
Budi SetiawanBinus University1
Sefanadia PutriIPB University1
Andi Eka YuniantoLampung University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/kemas/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Milk-based Drinks containing Lactic Acid Bacteria on Gut Dysbiosis and Birth Weight from Undernourished Pregnant Rats</dc:title>
	<dc:creator xml:lang="en">Nurwati, Yuni</dc:creator>
	<dc:creator xml:lang="en">Hardinsyah, Hardinsyah</dc:creator>
	<dc:creator xml:lang="en">Marliyati, Sri Anna</dc:creator>
	<dc:creator xml:lang="en">Fahrudin, Mokhamad</dc:creator>
	<dc:creator xml:lang="en">Ismawati, Rita</dc:creator>
	<dc:creator xml:lang="en">Afifah, Choirul Anna Nur</dc:creator>
	<dc:creator xml:lang="en">Soeyono, Rahayu Dewi</dc:creator>
	<dc:creator xml:lang="en">Audina, Nabilla Ersya</dc:creator>
	<dc:creator xml:lang="en">Pranoto, Adi</dc:creator>
	<dc:subject xml:lang="en">gut dysbiosis</dc:subject>
	<dc:subject xml:lang="en">induction of malnutrition</dc:subject>
	<dc:subject xml:lang="en">lactic acid bacteria</dc:subject>
	<dc:subject xml:lang="en">offspring birth weight</dc:subject>
	<dc:subject xml:lang="en">undernoursihed pregnant rats</dc:subject>
	<dc:description xml:lang="en">Lactic Acid Bacteria (LAB) can be an alternative intervention to help improve pregnancy outcomes. This study aimed to examine the effects of milk-based drinks (MBD) containing a single strain, namely Lactobacillus casei Shirota strain, and MBD containing multiple strains, namely Lactobacillus delbrueckii subsp. Bulgaricus, Lactobacillus paracasei, Lactobacillus rhamnosus, and Streptococcus thermophi- lus to improve gut dysbiosis and offspring birthweight in malnourished pregnant rats, conducted at the Experimental Animal Laboratory from 2020 to 2021. The sample consisted of female rats that were induced with malnutrition and mated. Twenty four female Sprague Dawley rats, aged 7-8 weeks, weighing 150-250 grams, were randomly divided into one negative control group (A0) and three malnourished groups. The malnourished groups consisted of the positive control group (A1), MBD-LcS group (A2), and MBD-multi strain group (A3). The intervention was administered for 19 days. Data was analyzed using ANOVA. Results showed that administering MBDs significantly affected total coliform bacteria (p&amp;lt;0.05).  Moreover, it significantly affected the offspring’s birth weight. The highest birth weight was found in the A3 group (5.18±0.88 g). Overall, prodiving MBDs containing beneficial bacteria significantly improved total coliform bacteria and pregnancy outcomes. Thus, it can help reduce nutritional and health problems in the future.</dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)</dc:publisher>
	<dc:date>2026-09-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/kemas/article/view/47429</dc:identifier>
	<dc:identifier>10.15294/kemas.v22i1.47429</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kesehatan Masyarakat; Vol. 22 No. 1 (2026); 163 - 170</dc:source>
	<dc:source>2355-3596</dc:source>
	<dc:source>1858-1196</dc:source>
	<dc:source>10.15294/kemas.v22i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/kemas/article/view/47429/11527</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Jurnal Kesehatan Masyarakat</dc:rights>
</oai_dc:dc>