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A New Opportunity Related Hypercholesterolemic and the Improvement of Glucose Levels, Lipid Profiles, and Microbial Activity: Red Dragon Fruit (Hylocereus polyrhizus) Peel Yogurt and Animal Study

Unnes Journal of Public Health · Vol. 13 No. 2 (2024) · hlm. 80–92

DOI
10.15294/ujph.v13i2.4365
ISSN
2548-7604, 2252-6781
Terbit
2024-09-25
Penerbit
Universitas Negeri Semarang (UNNES) in cooperation with the Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))
Bahasa
eng

Abstrak

Hypercholesterolemia estimated to cause 2.6 million deaths and 29.7 million disability problems.The incidence of Noncommunicable diseases (NCD) such as coronary heart disease (CHD), type2 diabetes, and some types of cancer can be involved with hypercholesterolemiaed. Red dragonfruit (Hylocereus polyrhizus) peel contains total phenolic compounds, flavonoids and dietary fiber.Red dragon fruit (Hylocereus polyrhizus) peel, which was originally considered as trash can beused to produce yogurt. This study aimed to analyse the effect of red dragon fruit (Hylocereuspolyrhizus) peel yogurt on levels of fasting blood glucose, lipid profile and microbial activity inhypercholesterolemic Wistar rats. This was an experimental- research with pre and post-test control group design. A total of 25 male Wistar rats were divided into five groups randomly. Hypercholesterolemic conditions in the Wistar rats were obtained from consuming solution consisted of 1% of cholesterol powder and 0.5% of cholic acid for 14 days. Each Wistar rats received 20 g/day standard feed. The grouping were Group 1 (negative control group); Group 2 (hypercholesterolemic group); Group 3 (1.8 ml/kg b.wt/day of dragon fruit peel yogurt); Group 4 (2.7 ml/kg b.wt/day of dragon fruit peel yogurt); Group 5 (3.6 ml/kg b.wt/day of dragon fruit peel yogurt). The intervention was performed for 28 days. Blood glucose levels and lipid profiles weremeasured before and after the intervention. Blood glucose, lipid profiles and microbial activity weremeasured using GOD-PAP, automatic biochemistry analyser and pour plate method respectively.Data were analysed using paired t test and one-way ANOVA. Blood glucose, TC, LDL-C, TGlevels were decreased, and the other side HDL-C was increased significantly in the Group dragonfruit peel. There was no difference in the total number of microbes in all groups. Dragon fruit peelyogurt is effective in improving glucose levels and lipid profile of hypercholesterolemic Wistar rats.

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  • State University of Semarang
  • Diponegoro University
  • Universitas Muhammadiyah Semarang
  • Universitas Bhakti Husada Indonesia
  • Universitas Respati Yogyakarta
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Rekan penulisOrganisasiArtikel bersama
Evi WidowatiState University of Semarang6
Intan ZainafreeState University of Semarang5
Dina Nur Anggraini NingrumState University of Semarang4
Oktia Woro Kasmini HandayaniState University of Semarang4
Ari YuniastutiState University of Semarang3
Yuni WijayantiState University of Semarang3
Nur SiyamState University of Semarang2
Mahalul AzamState University of Semarang2
Wandah WibawantoState University of Semarang2
Margareta RahayuningsihState University of Semarang2
Rafidha Nur AlifahState University of Semarang2
Russiska RussiskaUniversitas Bhakti Husada Indonesia2
Hanif Pandu SuhitoState University of Semarang2
Efa NugrohoState University of Semarang2
Casmuti CasmutiState University of Semarang2
Siti WahyuningsihUniversitas Respati Yogyakarta2
Salsabila Kinaya PraninditaState University of Semarang2
Della Rizky FitrianaState University of Semarang2
Bambang Budi RaharjoState University of Semarang2
Sofwan IndarjoState University of Semarang2
Sri Ratna RahayuState University of Semarang2
Surtianingsih WidiastutiState University of Semarang1
Selvia Mayka SyahputriState University of Semarang1
Karima Jafina Azka AnjaliState University of Semarang1
Sigit Ambar WidyawatiAfiliasi tidak diketahui1
Eka Radiyani OktaviaAfiliasi tidak diketahui1
Fatehah Rahma AgustinAfiliasi tidak diketahui1
Nandito Mapian MagaiAfiliasi tidak diketahui1
Annisa PramitasariState University of Semarang1
Dhea Istiva AyuState University of Semarang1
Dinta Alfiyanti RahayuState University of Semarang1
Annisa Sifa AprianiState University of Semarang1
Mamluatul HikmahState University of Semarang1
Chindy HermaniaState University of Semarang1
Puput Devi SaputriState University of Semarang1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/journals/ujph/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">A New Opportunity Related Hypercholesterolemic and the Improvement of Glucose Levels, Lipid Profiles, and Microbial Activity: Red Dragon Fruit (Hylocereus polyrhizus) Peel Yogurt and Animal Study</dc:title>
	<dc:creator xml:lang="en">Putriningtyas, Natalia Desy</dc:creator>
	<dc:creator xml:lang="en">Cahyati, Widya Hary</dc:creator>
	<dc:creator xml:lang="en">Kusuma, Refani Alycia</dc:creator>
	<dc:creator xml:lang="en">Nugraheni, Kartika</dc:creator>
	<dc:creator xml:lang="en">Nisa, Alfiana Ainun</dc:creator>
	<dc:description xml:lang="en"> Hypercholesterolemia estimated to cause 2.6 million deaths and 29.7 million disability problems.The incidence of Noncommunicable diseases (NCD) such as coronary heart disease (CHD), type2 diabetes, and some types of cancer can be involved with hypercholesterolemiaed. Red dragonfruit (Hylocereus polyrhizus) peel contains total phenolic compounds, flavonoids and dietary fiber.Red dragon fruit (Hylocereus polyrhizus) peel, which was originally considered as trash can beused to produce yogurt. This study aimed to analyse the effect of red dragon fruit (Hylocereuspolyrhizus) peel yogurt on levels of fasting blood glucose, lipid profile and microbial activity inhypercholesterolemic Wistar rats. This was an experimental- research with pre and post-test control group design. A total of 25 male Wistar rats were divided into five groups randomly. Hypercholesterolemic conditions in the Wistar rats were obtained from consuming solution consisted of 1% of cholesterol powder and 0.5% of cholic acid for 14 days. Each Wistar rats received 20 g/day standard feed. The grouping were Group 1 (negative control group); Group 2 (hypercholesterolemic group); Group 3 (1.8 ml/kg b.wt/day of dragon fruit peel yogurt); Group 4 (2.7 ml/kg b.wt/day of dragon fruit peel yogurt); Group 5 (3.6 ml/kg b.wt/day of dragon fruit peel yogurt). The intervention was performed for 28 days. Blood glucose levels and lipid profiles weremeasured before and after the intervention. Blood glucose, lipid profiles and microbial activity weremeasured using GOD-PAP, automatic biochemistry analyser and pour plate method respectively.Data were analysed using paired t test and one-way ANOVA. Blood glucose, TC, LDL-C, TGlevels were decreased, and the other side HDL-C was increased significantly in the Group dragonfruit peel. There was no difference in the total number of microbes in all groups. Dragon fruit peelyogurt is effective in improving glucose levels and lipid profile of hypercholesterolemic Wistar rats. </dc:description>
	<dc:publisher xml:lang="en">Universitas Negeri Semarang (UNNES) in cooperation with the Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))</dc:publisher>
	<dc:date>2024-09-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/journals/ujph/article/view/4365</dc:identifier>
	<dc:identifier>10.15294/ujph.v13i2.4365</dc:identifier>
	<dc:source xml:lang="en">Unnes Journal of Public Health; Vol. 13 No. 2 (2024); 80 - 92</dc:source>
	<dc:source>2548-7604</dc:source>
	<dc:source>2252-6781</dc:source>
	<dc:source>10.15294/ujph.v13i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/journals/ujph/article/view/4365/1204</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Unnes Journal of Public Health</dc:rights>
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