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PENINGKATAN CD8 DAN IFN-γ PADA HYPERSENSITIVITY PNEUMONITIS (HP) AKIBAT PAJANAN DEBU PENGGILINGAN PADI

Unnes Journal of Public Health · Vol. 6 No. 4 (2017) · hlm. 253–259

DOI
10.15294/ujph.v6i4.17732
ISSN
2548-7604, 2252-6781
Terbit
2017-10-15
Penerbit
Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))
Bahasa
eng

Abstrak

Abstrak Masalah klinis kesehatan kerja pada pekerja penggilingan padi saat ini adalah penyakit saluran pernafasan. Penelitian ini bertujuan untuk menganalisis peningkatan CD8 dan IFN-γ pada Pneumonitis Hipersensitif (HP) akibat pajanan debu penggilingan padi pada mencit (Musmusculus) BALB/C. Penelitian yang dilakukan adalah penelitian eksperimental laboratoris dengan hewan coba mencit (Musmusculus) BALB/C, rancangan penelitian yang digunakan adalah Randomized the post test only control group design. Mencit (Musmusculus) BALB/C dipajan dengan debu penggilingan padi selama empat jam/hari selama tiga puluh hari dengan konsentrasi 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3. Variabel bebas adalah debu penggilingan padi, sedangkan variabel tergantung adalah CD8 dan IFN-γ, serta gambaran histopatologis paru mencit, sedangkan variabel kendali adalah strain, berat badan, dan umur. Hasil penelitian menunjukkan bahwa terjadi peningkatan kadar CD8 antara kontrol dengan perlakuan, dan secara statistik ada perbedaan yang bermakna. Kemudian terjadi peningkatan IFN-γ dan secara statistik ada perbedaan yang bermakna antara kontrol dan perlakuan pada mencit (Musmusculus) BALB/C. Hasil penelitian dapat digunakan sebagai dasar upaya pencegahan dan pemberian terapi penyakit HP lebih dini sehingga dapat meningkatkan kualitas paru. Kata Kunci: CD8, IFN-γ, debu penggilingan padi Abtract The purpose of this research was to analyze increase of CD8 and IFN-γ of Hypersensitivity Pneumonitis (HP) as a result from the exposure of dust from paddy milling on mice (Musmusculus)BALB/C. The research done was a laboratory experimental research with mice (MusMusculus) as experimental animal. The research design used was the post only control group design using mice (MusMusculus) Balb/c as experimental animal. Mice (Musmusculus) Balb/c were exposed to dust from paddy milling for four (4) hours/day and it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The research variables were free variable, dependent variable, and control variable. Independent variable was dust from paddy milling, dependent variables were Hypersensitivity Pneumonitis (HP), CD8 and IFN-γ, while control variables were strain, body weight and age of mice (MusMusculus) Balb/c. The research result showed that there was an increase of CD8, and statistically there was significant difference; there was an increase on IFN-γ and statistically there was a significant difference between the study and control on mice BALB/C. It was suggested that: the research result be used to underlie a preventive action and an early therapy on Hypersensitivity Pneumonitis (HP) so that it increase the quality of lung. Keywords: CD8, IFN-γ, dust from paddy milling Abtract The purpose of this research was to analyze increase of CD8 and IFN-γ of Hypersensitivity Pneumonitis (HP) as a result from the exposure of dust from paddy milling on mice (Musmusculus)BALB/C. The research done was a laboratory experimental research with mice (MusMusculus) as experimental animal. The research design used was the post only control group design using mice (MusMusculus) Balb/c as experimental animal. Mice (Musmusculus) Balb/c were exposed to dust from paddy milling for four (4) hours/day and it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The research variables were free variable, dependent variable, and control variable. Independent variable was dust from paddy milling, dependent variables were Hypersensitivity Pneumonitis (HP), CD8 and IFN-γ, while control variables were strain, body weight and age of mice (MusMusculus) Balb/c. The research result showed that there was an increase of CD8, and statistically there was significant difference; there was an increase on IFN-γ and statistically there was a significant difference between the study and control on mice BALB/C. It was suggested that: the research result be used to underlie a preventive action and an early therapy on Hypersensitivity Pneumonitis (HP) so that it increase the quality of lung. Keywords: CD8, IFN-γ, dust from paddy milling

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  • Universitas Airlangga
  • Universitas Jember
  • Poltekkes Kemenkes Surabaya
  • Universitas Esa Unggul
  • Hasanuddin University
  • Universitas Karya Husada Semarang
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
Hari Basuki NotobrotoUniversitas Airlangga3
Hosizah HosizahUniversitas Esa Unggul2
Dewi RokhmahUniversitas Jember2
KhoironAfiliasi tidak diketahui2
Mochammad Bagus QomaruddinUniversitas Airlangga2
Rachmah IndawatiUniversitas Airlangga2
Basuki HariUniversitas Airlangga1
Anita Dewi MoelyaningrumUniversitas Jember1
Ninna RohmawatiUniversitas Jember1
FarianingsihAfiliasi tidak diketahui1
Hari BasukiUniversitas Airlangga1
Apik Indarty MoedjionoHasanuddin University1
Chatarina Umbul WahyuniUniversitas Airlangga1
Nursalam NursalamUniversitas Airlangga1
Fery Agusman Motuho MendrofaUniversitas Karya Husada Semarang1
Hasan MachfoedUniversitas Airlangga1
Rachmad HargonoUniversitas Airlangga1
Bagus WidjonarkoDiponegoro University1
Nugroho SusantoUniversitas Respati Yogyakarta1
Sunarsih SunarsihUniversitas Mandala Waluya1
Chatrin U.WAfiliasi tidak diketahui1
Globila NurikaUniversitas Jember1
Amanda Agustine ArwikanaUniversitas Jember1
Argus BaskoroUniversitas Airlangga1
Afrian Eskartya HarjonoUniversitas Airlangga1
Kiki Adi MutiariUniversitas Airlangga1
Silmi MunaUniversitas Airlangga1
Soenarnatalina MelanianiUniversitas Airlangga1
Wahyul AnisUniversitas Airlangga1
Nanik Dwi AstutikUniversitas Airlangga1
Angelina Da Costa FernandesInstituto Superior Cristal1
Ida Srisurani Wiji AstutiUniversitas Airlangga1
Krish Naufal Anugrah RobbyUniversitas Jember1
Yohanes Kambaru WindiPoltekkes Kemenkes Surabaya1
Loetfia Dwi RahariyaniPoltekkes Kemenkes Surabaya1
Nikmatul FadilahPoltekkes Kemenkes Surabaya1
Luluk WidartiPoltekkes Kemenkes Surabaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.unnes.ac.id/sju/index.php/ujph/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 6 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">PENINGKATAN  CD8 DAN IFN-γ PADA HYPERSENSITIVITY PNEUMONITIS (HP) AKIBAT PAJANAN DEBU PENGGILINGAN PADI</dc:title>
	<dc:creator>Ma'rufi, Isa</dc:creator>
	<dc:creator>Kuntoro, Kuntoro</dc:creator>
	<dc:creator>Keman, Soejdajadi</dc:creator>
	<dc:description xml:lang="en-US">Abstrak
&amp;nbsp;
&amp;nbsp;
Masalah klinis kesehatan kerja pada pekerja penggilingan padi saat ini adalah penyakit saluran pernafasan. Penelitian ini bertujuan untuk menganalisis peningkatan CD8 dan IFN-γ pada Pneumonitis Hipersensitif (HP) akibat pajanan debu penggilingan padi pada mencit&amp;nbsp; (Musmusculus) BALB/C. Penelitian yang dilakukan adalah penelitian eksperimental laboratoris dengan hewan coba mencit (Musmusculus) BALB/C,&amp;nbsp; rancangan penelitian yang digunakan adalah Randomized the post test only control group design. Mencit&amp;nbsp; (Musmusculus) BALB/C dipajan dengan debu penggilingan padi selama empat jam/hari selama tiga puluh hari dengan konsentrasi 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3. Variabel bebas adalah debu penggilingan padi, sedangkan variabel tergantung adalah&amp;nbsp; &amp;nbsp;CD8 dan IFN-γ, serta gambaran histopatologis paru mencit, sedangkan variabel kendali adalah strain, berat badan, dan umur. Hasil penelitian menunjukkan bahwa terjadi peningkatan kadar CD8 antara kontrol dengan perlakuan, dan secara statistik&amp;nbsp; ada perbedaan yang bermakna. Kemudian terjadi peningkatan IFN-γ dan secara statistik ada perbedaan yang bermakna antara kontrol dan perlakuan pada mencit&amp;nbsp; (Musmusculus) BALB/C. Hasil penelitian dapat digunakan sebagai dasar upaya pencegahan dan pemberian terapi penyakit HP lebih dini sehingga dapat meningkatkan kualitas paru.
&amp;nbsp;
Kata Kunci: CD8, IFN-γ, &amp;nbsp;debu penggilingan padi
&amp;nbsp;
&amp;nbsp;
Abtract
&amp;nbsp;
The purpose of this research was to analyze increase of CD8&amp;nbsp; and IFN-γ of Hypersensitivity Pneumonitis (HP) as a result from the exposure of dust from paddy milling on mice (Musmusculus)BALB/C. The research done was a laboratory experimental research with mice (MusMusculus) as experimental animal.&amp;nbsp; The research design used was the post only control group design using mice (MusMusculus) Balb/c as experimental animal.&amp;nbsp; Mice (Musmusculus) Balb/c were exposed to dust from paddy milling for four (4) hours/day and it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The research variables were free variable, dependent variable, and control variable.&amp;nbsp; Independent variable was dust from paddy milling, dependent variables were Hypersensitivity Pneumonitis (HP), CD8 and IFN-γ, while control variables were strain, body weight and age of mice (MusMusculus) Balb/c. The research result showed that there was an increase of CD8, and statistically there was significant difference; there was an increase on IFN-γ and statistically there was a significant difference between the study and control on mice BALB/C. It was suggested that:&amp;nbsp; the research result be used to underlie a preventive action and an early therapy on Hypersensitivity Pneumonitis (HP) so that it increase the quality of lung.
&amp;nbsp;
Keywords: CD8, IFN-γ, dust from paddy milling
&amp;nbsp;
&amp;nbsp;
Abtract
&amp;nbsp;
The purpose of this research was to analyze increase of CD8&amp;nbsp; and IFN-γ of Hypersensitivity Pneumonitis (HP) as a result from the exposure of dust from paddy milling on mice (Musmusculus)BALB/C. The research done was a laboratory experimental research with mice (MusMusculus) as experimental animal.&amp;nbsp; The research design used was the post only control group design using mice (MusMusculus) Balb/c as experimental animal.&amp;nbsp; Mice (Musmusculus) Balb/c were exposed to dust from paddy milling for four (4) hours/day and it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The research variables were free variable, dependent variable, and control variable.&amp;nbsp; Independent variable was dust from paddy milling, dependent variables were Hypersensitivity Pneumonitis (HP), CD8 and IFN-γ, while control variables were strain, body weight and age of mice (MusMusculus) Balb/c. The research result showed that there was an increase of CD8, and statistically there was significant difference; there was an increase on IFN-γ and statistically there was a significant difference between the study and control on mice BALB/C. It was suggested that:&amp;nbsp; the research result be used to underlie a preventive action and an early therapy on Hypersensitivity Pneumonitis (HP) so that it increase the quality of lung.
&amp;nbsp;
Keywords: CD8, IFN-γ, dust from paddy milling
&amp;nbsp;</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))</dc:publisher>
	<dc:date>2017-10-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unnes.ac.id/sju/ujph/article/view/17732</dc:identifier>
	<dc:identifier>10.15294/ujph.v6i4.17732</dc:identifier>
	<dc:source xml:lang="en-US">Unnes Journal of Public Health; Vol 6 No 4 (2017): Unnes Journal of Public Health; 253-259</dc:source>
	<dc:source>2548-7604</dc:source>
	<dc:source>2252-6781</dc:source>
	<dc:source>10.15294/ujph.v6i4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.unnes.ac.id/sju/ujph/article/view/17732/9328</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2017 Unnes Journal of Public Health</dc:rights>
</oai_dc:dc>