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Isolation and characterization of microcrystalline cellulose from tangkit pineapple leaves (ACT-MCC) as a pharmaceutical excipient

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · hlm. 424–432

DOI
10.22437/proca.v1i2.50265
Terbit
2025-11-26
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Microcrystalline cellulose (MCC) is a widely used pharmaceutical excipient due to its high compressibility, stability, and inertness in tablet formulations. Tangkit pineapple leaves (Ananas comosus), an abundant agricultural waste in Jambi, Indonesia, offer a sustainable alternative source for cellulose. Objective: This study reports the preparation and characterization of microcrystalline cellulose (ACT-MCC) derived from Tangkit pineapple leaves, as well as its physicochemical characteristics in comparison to the commercial standard, Avicel PH 102. Methods: MCC was prepared from α-cellulose isolated from dried Tangkit pineapple leaves through sequential alkali treatment, bleaching, and acid hydrolysis. Results: From 200 g of dried raw material, 19.41% (w/w) α-cellulose was obtained, which was then converted to 75% (w/w) MCC, equivalent to 14.56% of the starting material. The resulting ACT-MCC had a melting point of 247-250°C, slightly lower than Avicel PH 102 (268-270 °C). Physicochemical analysis showed a pH of 7.51, total ash 0.318% (w/w), moisture 3.13% (w/w), and drying loss of 3.42% (w/w), all within pharmacopeial limits. ACT-MCC was comparatively fine, odourless, tasteless, and yellowish in appearance. Conclusion: ATC-MCC demonstrated comparable characteristics to commercial MCC, indicating its potential usage as a locally derived pharmaceutical excipient.

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Isolation and characterization of microcrystalline cellulose from tangkit pineapple leaves (ACT-MCC) as a pharmaceutical excipient</dc:title>
	<dc:creator xml:lang="en">Astuti, Novia Tri</dc:creator>
	<dc:creator xml:lang="en">Efendi, M. Rifqi</dc:creator>
	<dc:creator xml:lang="en">Sadli, Nurul Kamilah</dc:creator>
	<dc:creator xml:lang="en">Pondawinata, Marizki</dc:creator>
	<dc:creator xml:lang="en">Ladianti, Cintasa Nabila</dc:creator>
	<dc:creator xml:lang="en">Apriani, Ela</dc:creator>
	<dc:subject xml:lang="en">Tangkit pineapple leaves</dc:subject>
	<dc:subject xml:lang="en">MCC</dc:subject>
	<dc:subject xml:lang="en">ATC-MCC</dc:subject>
	<dc:subject xml:lang="en">Physicochemical Characterization</dc:subject>
	<dc:subject xml:lang="en">Pharmaceutical excipient</dc:subject>
	<dc:description xml:lang="en">Background: Microcrystalline cellulose (MCC) is a widely used pharmaceutical excipient due to its high compressibility, stability, and inertness in tablet formulations. Tangkit pineapple leaves (Ananas comosus), an abundant agricultural waste in Jambi, Indonesia, offer a sustainable alternative source for cellulose. Objective: This study reports the preparation and characterization of microcrystalline cellulose (ACT-MCC) derived from Tangkit pineapple leaves, as well as its physicochemical characteristics in comparison to the commercial standard, Avicel PH 102. Methods: MCC was prepared from α-cellulose isolated from dried Tangkit pineapple leaves through sequential alkali treatment, bleaching, and acid hydrolysis. Results: From 200 g of dried raw material, 19.41% (w/w) α-cellulose was obtained, which was then converted to 75% (w/w) MCC, equivalent to 14.56% of the starting material. The resulting ACT-MCC had a melting point of 247-250°C, slightly lower than Avicel PH 102 (268-270 °C). Physicochemical analysis showed a pH of 7.51, total ash 0.318% (w/w), moisture 3.13% (w/w), and drying loss of 3.42% (w/w), all within pharmacopeial limits. ACT-MCC was comparatively fine, odourless, tasteless, and yellowish in appearance. Conclusion: ATC-MCC demonstrated comparable characteristics to commercial MCC, indicating its potential usage as a locally derived pharmaceutical excipient.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50265</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50265</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 424-432</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50265/22599</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Novia Tri Astuti, M. Rifqi Efendi, Nurul Kamilah Sadli, Marizki Pondawinata, Cintasa Nabila Ladianti, Ela Apriani</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>