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Immunoexpression of hormonal receptors in phyllodes tumors

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · hlm. 509–517

DOI
10.22437/proca.v1i2.50323
Terbit
2025-11-27
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast characterized by biphasic proliferation of epithelial and stromal components. The role of hormonal receptors such as estrogen receptor (ER) and progesterone receptor (PR) in PT remains unclear, particularly in relation to tumor grade and stromal behavior. Objective: This study aimed to evaluate the immunoexpression of ER and PR in both stromal and epithelial components of phyllodes tumors and analyze their correlation with histologic grade (benign, borderline, and malignant). Methods: A retrospective cross-sectional study was conducted on 49 archived FFPE samples of phyllodes tumors diagnosed at the Department of Pathology, Universitas Jambi Hospital. Two samples were excluded due to poor tissue quality, leaving 47 cases for immunohistochemical (IHC) evaluation. ER and PR expression were assessed semi-quantitatively in epithelial and stromal cells, and correlations with tumor grade were analyzed using Chi-square and Spearman tests. Results: Among 47 evaluable cases, 28 (59.6%) were benign, 12 (25.5%) borderline, and 7 (14.9%) malignant. ER and PR were expressed predominantly in epithelial cells, with low positivity in stromal cells. No significant correlation was found between ER/PR expression and histologic grade (p > 0.05). Conclusion: Hormonal receptor expression does not correlate significantly with histologic grade of phyllodes tumors, suggesting a limited role of ER and PR in tumor progression.

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Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Immunoexpression of hormonal receptors in phyllodes tumors</dc:title>
	<dc:creator xml:lang="en">Fairuz</dc:creator>
	<dc:creator xml:lang="en">Humaryanto</dc:creator>
	<dc:creator xml:lang="en">Asparian</dc:creator>
	<dc:subject xml:lang="en">immunoexpression</dc:subject>
	<dc:subject xml:lang="en">horomonal receptors</dc:subject>
	<dc:subject xml:lang="en">pyhllodes tumors</dc:subject>
	<dc:description xml:lang="en">Background: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast characterized by biphasic proliferation of epithelial and stromal components. The role of hormonal receptors such as estrogen receptor (ER) and progesterone receptor (PR) in PT remains unclear, particularly in relation to tumor grade and stromal behavior. Objective: This study aimed to evaluate the immunoexpression of ER and PR in both stromal and epithelial components of phyllodes tumors and analyze their correlation with histologic grade (benign, borderline, and malignant). Methods: A retrospective cross-sectional study was conducted on 49 archived FFPE samples of phyllodes tumors diagnosed at the Department of Pathology, Universitas Jambi Hospital. Two samples were excluded due to poor tissue quality, leaving 47 cases for immunohistochemical (IHC) evaluation. ER and PR expression were assessed semi-quantitatively in epithelial and stromal cells, and correlations with tumor grade were analyzed using Chi-square and Spearman tests. Results: Among 47 evaluable cases, 28 (59.6%) were benign, 12 (25.5%) borderline, and 7 (14.9%) malignant. ER and PR were expressed predominantly in epithelial cells, with low positivity in stromal cells. No significant correlation was found between ER/PR expression and histologic grade (p &amp;gt; 0.05). Conclusion: Hormonal receptor expression does not correlate significantly with histologic grade of phyllodes tumors, suggesting a limited role of ER and PR in tumor progression.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50323</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50323</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 509-517</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50323/22614</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Fairuz, Humaryanto, Asparian</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>