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Antioxidant activity potential of 96% ethanol extract from jackfruit (Artocarpus integer) peel based on IC50 value

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · hlm. 722–727

DOI
10.22437/proca.v1i2.50328
Terbit
2025-11-30
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Jackfruit (Artocarpus integer) peel is an agricultural waste with potential as a source of bioactive compounds. Objective: This study aims to evaluate the potential antioxidant activity of cempedak fruit peel extract using a 96% ethanol solvent. The extract, tested as fraction F3P, is believed to contain phenolic and flavonoid compounds that act as free radical scavengers. Extraction was performed using the maceration method. Methods: Antioxidant activity was tested in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method at various concentrations, ranging from 20 ppm to 100 ppm. Based on the percentage inhibition data obtained, the IC50 (Inhibitory Concentration 50%) value was calculated through logarithmic/linear regression analysis. Results: The calculation results show that the 96% ethanol extract of cempedak fruit peel (fraction F3P) has an IC50 value of 8.872 ppm. This IC50 value, which is below 50 ppm, indicates that the extract has very strong antioxidant activity. The active compounds within it can reduce 50% of DPPH free radicals at very low concentrations. Conclusion: This study concludes that the 96% ethanol extract of cempedak fruit peel is a highly potent and valuable source of natural antioxidants. Utilizing jackfruit peel waste can be a solution for developing functional food products or health supplements.

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  • Universitas Jambi
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Zahra Frizki AstyAfiliasi tidak diketahui11
Annissa DelfiraAfiliasi tidak diketahui9
Mara Imam Taufiq SiregarUniversitas Jambi9
Mirna Marhami IskandarAfiliasi tidak diketahui8
Patrick Wiliam GadingAfiliasi tidak diketahui5
Budi JustitiaAfiliasi tidak diketahui5
Zilzikridini WijayantiAfiliasi tidak diketahui4
Tengku Arief Buana PerkasaAfiliasi tidak diketahui4
Dea Anenta VeonikaAfiliasi tidak diketahui4
Tia Wida Ekaputri Hz HzAfiliasi tidak diketahui4
Willy hardi MarpaungAfiliasi tidak diketahui4
Raihanah SusanAfiliasi tidak diketahui4
Tia Wida Ekaputri HzAfiliasi tidak diketahui4
HaninaAfiliasi tidak diketahui4
Rita HalimUniversitas Jambi4
Raihanah SuzanAfiliasi tidak diketahui4
Afifah AmatullahAfiliasi tidak diketahui3
Huntari HarahapAfiliasi tidak diketahui2
Attiya IstariniAfiliasi tidak diketahui2
Ahmad Thohir HidayatAfiliasi tidak diketahui2
Armaidi DarmawanAfiliasi tidak diketahui2
FairuzAfiliasi tidak diketahui2
FitriyantiAfiliasi tidak diketahui2
Muhammad SyukriUniversitas Halu Oleo2
Rina Nofri EnisAfiliasi tidak diketahui1
Tia Wida EkaputriAfiliasi tidak diketahui1
Anggelia PuspasariAfiliasi tidak diketahui1
Citra MaharaniAfiliasi tidak diketahui1
Nadir Putra Indra TariganAfiliasi tidak diketahui1
Widya Lawra ArrahmaAfiliasi tidak diketahui1
Syahreza Hadi JuandaAfiliasi tidak diketahui1
Tengku Irfan Wira BuanaAfiliasi tidak diketahui1
Erny KusdiyahAfiliasi tidak diketahui1
Wahyu Indah Dewi AuroraAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Antioxidant activity potential of 96% ethanol extract from jackfruit (Artocarpus integer) peel based on IC50 value</dc:title>
	<dc:creator xml:lang="en">Ayudia, Esa Indah</dc:creator>
	<dc:creator xml:lang="en">Miftahurrahmah</dc:creator>
	<dc:creator xml:lang="en">Lipinwati</dc:creator>
	<dc:creator xml:lang="en">Dewi, Hasna</dc:creator>
	<dc:creator xml:lang="en">Hafizah</dc:creator>
	<dc:creator xml:lang="en">Denok Tri Hardiningsih</dc:creator>
	<dc:subject xml:lang="en">Jackfruit Peel; 96% Ethanol; DPPH, Antioxidant; IC50; Artocarpus integer</dc:subject>
	<dc:description xml:lang="en">Background: Jackfruit (Artocarpus integer) peel is an agricultural waste with potential as a source of bioactive compounds. Objective: This study aims to evaluate the potential antioxidant activity of cempedak fruit peel extract using a 96% ethanol solvent. The extract, tested as fraction F3P, is believed to contain phenolic and flavonoid compounds that act as free radical scavengers. Extraction was performed using the maceration method. Methods: Antioxidant activity was tested in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging method at various concentrations, ranging from 20 ppm to 100 ppm. Based on the percentage inhibition data obtained, the IC50 (Inhibitory Concentration 50%) value was calculated through logarithmic/linear regression analysis. Results: The calculation results show that the 96% ethanol extract of cempedak fruit peel (fraction F3P) has an IC50 value of 8.872 ppm. This IC50 value, which is below 50 ppm, indicates that the extract has very strong antioxidant activity. The active compounds within it can reduce 50% of DPPH free radicals at very low concentrations. Conclusion: This study concludes that the 96% ethanol extract of cempedak fruit peel is a highly potent and valuable source of natural antioxidants. Utilizing jackfruit peel waste can be a solution for developing functional food products or health supplements.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50328</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50328</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 722-727</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50328/22662</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Esa Indah Ayudia, Miftahurrahmah, Lipinwati, Hasna Dewi, Hafizah, Denok Tri Hardiningsih</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>