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Evaluation of the antidiabetic activity of ethyl acetate partition of ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) on male white mice induced by alloxan

Proceedings Academic Universitas Jambi · Vol. 1 No. 2 (2025) · hlm. 929–934

DOI
10.22437/proca.v1i2.50511
Terbit
2025-11-30
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

Background: Diabetes mellitus is a condition where blood glucose levels increase due to a decrease in the amount or sensitivity of insulin produced by the body. Previous research has shown that the ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f.) Schott) has potential as an antidiabetic agent. The extract also contains several secondary metabolic compounds such as flavonoids and phenolics, which are suspected to have antidiabetic potential. Objective: This research aims to investigate the activity of ethyl acetate partitioning of Ekor Naga leaves extract (Rhaphidophora pinnata (L.f.) Schott) in reducing blood sugar levels in diabetic mice. Methods: This research employed a Completely Randomized Design (CRD) method with six treatments: a normal control, a glibenclamide positive control, a Na-CMC negative control, and treatment groups with doses of 125, 250, and 500 mg/kg body weight (BW) of the ethyl acetate partition of ekor naga leaves extract. The observed parameter was the average decrease in blood sugar levels over a 21-day period.Results: The results were analyzed using the one-way ANOVA test, followed by Duncan's multiple range test. The research showed that the ethyl acetate partition of Ekor Naga leaves can reduce blood sugar levels in mice over 21 days. The results have shown significant improvement in blood sugar levels between treatment groups. The best dose in reducing blood glucose levels was 500 mg/KgBW with a percentage decrease of 58.98%.Conclusion: Ethyl acetate partition of ekor naga leaves has potential as an antidiabetic agent.

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/PROCA/oai, pertama di-harvest 6 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Evaluation of the antidiabetic activity of ethyl acetate partition of ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) on male white mice induced by alloxan</dc:title>
	<dc:creator xml:lang="en">Kasmadi, Fathnur Sani</dc:creator>
	<dc:creator xml:lang="en">Maimum</dc:creator>
	<dc:creator xml:lang="en">Yuliawati</dc:creator>
	<dc:creator xml:lang="en">Maharini, Indri</dc:creator>
	<dc:creator xml:lang="en">Sari, Vinka Lupita</dc:creator>
	<dc:creator xml:lang="en">Hz, Tia Wida Ekaputri</dc:creator>
	<dc:creator xml:lang="en">Perkasa, Tengku Arief Buana</dc:creator>
	<dc:subject xml:lang="en">Ekor naga leaves; antidiabetic; blood sugar; partition; alloxan</dc:subject>
	<dc:description xml:lang="en">Background: Diabetes mellitus is a condition where blood glucose levels increase due to a decrease in the amount or sensitivity of insulin produced by the body. Previous research has shown that the ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f.) Schott) has potential as an antidiabetic agent. The extract also contains several secondary metabolic compounds such as flavonoids and phenolics, which are suspected to have antidiabetic potential. Objective: This research aims to investigate the activity of ethyl acetate partitioning of Ekor Naga leaves extract (Rhaphidophora pinnata (L.f.) Schott) in reducing blood sugar levels in diabetic mice. Methods: This research employed a Completely Randomized Design (CRD) method with six treatments: a normal control, a glibenclamide positive control, a Na-CMC negative control, and treatment groups with doses of 125, 250, and 500 mg/kg body weight (BW) of the ethyl acetate partition of ekor naga leaves extract. The observed parameter was the average decrease in blood sugar levels over a 21-day period.Results: The results were analyzed using the one-way ANOVA test, followed by Duncan's multiple range test. The research showed that the ethyl acetate partition of Ekor Naga leaves can reduce blood sugar levels in mice over 21 days. The results have shown significant improvement in blood sugar levels between treatment groups. The best dose in reducing blood glucose levels was 500 mg/KgBW with a percentage decrease of 58.98%.Conclusion: Ethyl acetate partition of ekor naga leaves has potential as an antidiabetic agent.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/PROCA/article/view/50511</dc:identifier>
	<dc:identifier>10.22437/proca.v1i2.50511</dc:identifier>
	<dc:source xml:lang="en">Proceedings Academic Universitas Jambi; Vol. 1 No. 2 (2025): The 6th Jambi Medicine and Health Science International Conference (JAMHESIC); 929-934</dc:source>
	<dc:source>10.22437/proca.v1i2</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/PROCA/article/view/50511/22710</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Fathnur Sani Kasmadi, Maimum, Yuliawati, Indri Maharini, Vinka Lupita Sari, Tia Wida Ekaputri Hz, Tengku Arief Buana Perkasa</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>